Richard D. Leapman

Activity-dependent calcium sequestration in dendrites of hippocampal neurons in brain slices.

Stimulus-secretion coupling in neurohypophysial nerve endings: a role for intravesicular sodium?

Multiple quantum solid-state NMR indicates a parallel, not antiparallel, organization of beta-sheets in Alzheimer's beta-amyloid fibrils.

Multiple modes of calcium-induced calcium release in sympathetic neurons II: a [Ca2+](i)- and location-dependent transition from endoplasmic reticulum Ca accumulation to net Ca release.

Oligomeric structure of virion-associated and soluble forms of the simian immunodeficiency virus envelope protein in the prefusion activated conformation.

Oligomeric structure of the human immunodeficiency virus type 1 envelope protein on the virion surface.

A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR.

Mass distribution and spatial organization of the linear bacterial motor of Spiroplasma citri R8A2.

Promoting trimerization of soluble human immunodeficiency virus type 1 (HIV-1) Env through the use of HIV-1/simian immunodeficiency virus chimeras.

Organization of designed nanofibrils assembled from alpha-helical peptides as determined by electron microscopy.

Novel techniques in electron microscopy.

Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils.

Mass of the postsynaptic density and enumeration of three key molecules.

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas.

Evaluation of bioreactor-cultivated bone by magnetic resonance microscopy and FTIR microspectroscopy.

Localizing specific elements bound to macromolecules by EFTEM.

Protein oxidation implicated as the primary determinant of bacterial radioresistance.

RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose.

Organization of the core structure of the postsynaptic density.

Molecular structural basis for polymorphism in Alzheimer's beta-amyloid fibrils.

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells.

Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.

Seeded growth of beta-amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure.

Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors.

Influence of melanosome dynamics on melanoma drug sensitivity.

Nanoscale 3D cellular imaging by axial scanning transmission electron tomography.

Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes.

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast.

Dual-axis electron tomography of biological specimens: Extending the limits of specimen thickness with bright-field STEM imaging.

Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice.

PSD-95 is required to sustain the molecular organization of the postsynaptic density.

Combining portable Raman probes with nanotubes for theranostic applications.

Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI.

Synthesis, characterization, and direct intracellular imaging of ultrasmall and uniform glutathione-coated gold nanoparticles.

Nuclear mapping of nanodrug delivery systems in dynamic cellular environments.

Direct visualization of CaMKII at postsynaptic densities by electron microscopy tomography.

Development and application of STEM for the biological sciences.

Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM.

Mass mapping of amyloid fibrils in the electron microscope using STEM imaging.

Elemental mapping by electron energy loss spectroscopy in biology.

Cryo-electron tomography of the magnetotactic vibrio Magnetovibrio blakemorei: insights into the biomineralization of prismatic magnetosomes.

Biodegradable gold nanovesicles with an ultrastrong plasmonic coupling effect for photoacoustic imaging and photothermal therapy.

A structural framework for a near-minimal form of life: mass and compositional analysis of the helical mollicute Spiroplasma melliferum BC3.

Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance.

Passive diffusion as a mechanism underlying ribbon synapse vesicle release and resupply.

Self-organized Mn-Block Copolymer Complexes and Their Use for MR Imaging of Biological Processes.

Variations in Glycogen Synthesis in Human Pluripotent Stem Cells with Altered Pluripotent States.

PSD-95 family MAGUKs are essential for anchoring AMPA and NMDA receptor complexes at the postsynaptic density.

STEM tomography reveals that the canalicular system and α-granules remain separate compartments during early secretion stages in blood platelets.

Biointeractions of ultrasmall glutathione-coated gold nanoparticles: effect of small size variations.

Compressed Sensing Electron Tomography for Determining Biological Structure.

Physicochemical characterization of ferumoxytol, heparin and protamine nanocomplexes for improved magnetic labeling of stem cells.

Golgi proteins in circulating human platelets are distributed across non-stacked, scattered structures.

Tri-stimuli-responsive biodegradable theranostics for mild hyperthermia enhanced chemotherapy.

PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

Application of EELS and EFTEM to the life sciences enabled by the contributions of Ondrej Krivanek.

Cells containing aragonite crystals mediate responses to gravity in Trichoplax adhaerens (Placozoa), an animal lacking neurons and synapses.

Comparison of 3D cellular imaging techniques based on scanned electron probes: Serial block face SEM vs. Axial bright-field STEM tomography.

Dotted Core-Shell Nanoparticles for T -Weighted MRI of Tumors.

Biological serial block face scanning electron microscopy at improved z-resolution based on Monte Carlo model.

SNARE-dependent membrane fusion initiates α-granule matrix decondensation in mouse platelets.

Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography.

Quantitative method for estimating stain density in electron microscopy of conventionally prepared biological specimens.

Determination of secretory granule maturation times in pancreatic islet β-cells by serial block-face electron microscopy.

Circadian Modulation of Neurons and Astrocytes Controls Synaptic Plasticity in Hippocampal Area CA1.

Venous puncture wound hemostasis results in a vaulted thrombus structured by locally nucleated platelet aggregates.

Palmitoylation of A-kinase anchoring protein 79/150 modulates its nanoscale organization, trafficking, and mobility in postsynaptic spines.

Tethered platelet capture provides a mechanism for restricting circulating platelet activation to the wound site.