affinity-purification-of-a-fibrinolytic-enzyme-from-sipunculus-nudus

Affinity Purification of a Fibrinolytic Enzyme from <em>Sipunculus nudus</em>

The fibrinolytic enzyme from Sipunculus nudus (sFE) is a novel fibrinolytic agent that can both activate plasminogen into plasmin and degrade fibrin ...

a-comprehensive-approach-to-analyze-cell-components-cerebral-blood

A Comprehensive Approach to Analyze the Cell Components of Cerebral Blood Clots

Cerebral thrombosis, a blood clot in a cerebral artery or vein, is the most common type of cerebral infarction. The study of the cell components of ...

rapid-separation-display-active-fibrinogenolytic-agents-sipunculus

Rapid Separation and Display of Active Fibrinogenolytic Agents in <i>Sipunculus nudus</i> through Fibrinogen-Polyacrylamide Gel Electrophoresis

Fibrinogenolytic agents that can dissolve fibrinogen directly have been widely used in anti-coagulation treatment. Generally, identifying new ...

electroacupuncture-combined-with-chinese-medicine-ironing-therapy-for

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Functional constipation (FC) is a dysfunctional gastrointestinal disease with the main clinical manifestations of complex bowel movements, incomplete ...

Huaqiao University

Engineering Research Centre of Molecular Medicine of Ministry of Education

huaqiao university

Zigong First People's Hospital

Only 1.5% of the human genome encodes proteins, while large part of the remaining encodes noncoding RNAs (ncRNA). Many ncRNAs form structures and perform many important functions. Accurately identifying structured ncRNAs in the human genome and discovering their biological functions remain a major challenge.

Identification of 11 candidate structured noncoding RNA motifs in humans by comparative genomics.

Thrombosis has been emerging as a major global life-threatening issue with high mortality and serious complications, especially in the post-COVID-19 era. Compared with the commonly used plasminogen activators thrombolytic drugs, fibrinolytic drugs are no longer heavily dependent on the patients' own plasminogen, which are poorly expressed in most patients. As a novel "direct acting" thrombolytic agent, fibrinolytic drugs are considered to have stronger thrombolytic efficacy and safety than the widely used plasminogen activators. However, the risk of their hemorrhage remains a major concern. Herein, the molecular mechanisms and solutions were summarized for the first time based on the systematic review of the latest developments, which could shed new light on the development of novel safety fibrinolytic drugs in the future.

Fibrinolytic drugs induced hemorrhage: mechanisms and solutions.

 Clinical evidence suggests that acupuncture is effective for relieving abdominal pain and distension in acute pancreatitis (AP). However, there is a lack of systematic reviews and meta-analyses that provide high-quality evidence of the efficacy and safety of acupuncture in this context.  To assess the efficacy and safety of acupuncture for relieving abdominal pain and distension in AP.  We searched the PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang, VIP, and China Biomedical Literature databases. Randomized controlled trials of acupuncture plus routine treatment (RT) vs. RT alone or RT plus sham/placebo acupuncture were included. Primary outcomes included total effectiveness rate, VAS scores for abdominal pain and distension, and time until relief of abdominal pain and distension. Secondary outcomes included time until recovery of bowel sound, time until first defecation, length of hospital stay, and APACHE II score.  Nineteen eligible original studies ( = 1,503) were included. The results showed that acupuncture in combination with RT had a significant advantage in terms of increasing the total effectiveness rate [risk ratio: 1.15; 95% confidence interval (CI): 1.06-1.24;  = 0.001]. Acupuncture also reduced the VAS score for abdominal pain [weighted mean difference (WMD): -1.45; 95% CI: -1.71 to -1.19;  < 0.0001] and the VAS score for abdominal distension (WMD: -0.71; 95% CI: -1.04 to -0.37;  < 0.0001) in patients with AP. Other results also showed the efficacy of acupuncture. One study reported adverse events after acupuncture.  Acupuncture in combination with RT has a better effect than RT alone for relieving abdominal pain and distension in AP. More rigorous studies are needed to confirm this result.  PROSPERO CRD42019147503 (https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=147503).

Acupuncture for Relieving Abdominal Pain and Distension in Acute Pancreatitis: A Systematic Review and Meta-Analysis.

 At present, a number of systematic reviews (SRs) on Xuebijing injection (a patent in China) in the treatment of acute pancreatitis (AP) or severe acute pancreatitis (SAP) have been published. However, the quality of evidence is uneven and has not been comprehensively evaluated.  We evaluated the efficacy of Xuebijing injection for AP/SAP through an overview of SR, and to provide a scientific basis for its effectiveness and safety.  We searched Cochrane Library, Embase, PubMed, SinoMed, CNKI, Wanfang, and VIP comprehensively. The retrieval period from inception to 30 November 2021, and the two reviewers independently complete the literature retrieval, data extraction and evaluation. The Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR-2) and the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) were used to evaluate the methodological quality and reporting quality of the SRs, respectively. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) tool was used to evaluate the quality grading of outcomes and the risk of bias in SRs was evaluated by ROBIS Tool. Finally, the RCTs involved in SRs were synthesized. Stata15.1 was used for quantitative analysis of total effectiveness rate, time until relief of abdominal pain, time until relief of abdominal distension, and serum amylase level.  Nine eligible SRs were included, including 92 RCTs and 6,837 participants. The quality of SRs was relatively good, and the manuscript structures were relatively complete. However, the methodological quality of SRs was low or critically low. RoB rated 5 SRs as low risk of bias and 4 SRs as high risk of bias. In GRADE, a total of 47 results were included in the 9 SRs, of which 5 results (10.64%) were moderate quality, 22 results (46.81%) were low quality, and 20 results (42.55%) were very low quality. The results of data synthesis showed that Xuebijing injection combined treatment increased the total effectiveness rate of AP patients (RR = 1.19, 95% CI 1.17-1.23,  < 0.0001), and there was no heterogeneity between studies (I = 0.0%,  = 0.589). Compared with the control group, Xuebijing injection group shortened the abdominal pain and distension relief time in AP patients (WMD = -1.69, 95% CI -1.88--1.50,  < 0.0001; WMD = -1.48, 95% CI -1.74--1.23,  < 0.0001), with high heterogeneity (I = 84.3%,  = 0.000; I = 72.2%,  = 0.000). Serum amylase level was also reduced (WMD = -2.06, 95% CI -2.47--1.64,  < 0.0001), with significant heterogeneity (I = 71.6%,  = 0.000). A total of one SR reported adverse drug reaction (ADR), no ADRs were observed in the control group.  Although the quality of the evidence is not high, it can still reflect the clinical value of Xuebijing injection as an analgesic and anti-inflammatory traditional Chinese medicine in the treatment of AP/SAP. Therefore, future clinical studies should focus on the long-term efficacy and adverse reactions of drugs.  (website), identifier (registration number).

Chinese herbal medicine xuebijing injection for acute pancreatitis: An overview of systematic reviews.

Migraine is a neurological disease characterized by moderate to severe headache and various neurological symptoms. It is often cause mood and anxiety disorders that can seriously affect quality of life. Acupuncture has been claimed to have a role in treating neuropsychiatric disorders and is becoming increasingly popular. However, it remains unclear whether current evidence is sufficient to support acupuncture in improving mental health in migraine patients.

Article Total : 4	Year
Publication title	2023
Publication title	2023
Publication title	2024
Publication title	2024

Article	Year
Identification of 11 candidate structured noncoding RNA motifs in humans by comparative genomics. BMC genomics\| PubMed ID: 33750298	2021
Fibrinolytic drugs induced hemorrhage: mechanisms and solutions. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis\| PubMed ID: 37395191	2023
Acupuncture for Relieving Abdominal Pain and Distension in Acute Pancreatitis: A Systematic Review and Meta-Analysis. Frontiers in psychiatry\| PubMed ID: 34925110	2021
Chinese herbal medicine xuebijing injection for acute pancreatitis: An overview of systematic reviews. Frontiers in pharmacology\| PubMed ID: 36034818	2022
Effects of acupuncture on mental health of migraine patients: a systematic review and meta-analysis. BMC complementary medicine and therapies\| PubMed ID: 37542321	2023
Symptom relief for patients with constipation. Asian journal of surgery\| PubMed ID: 37640644	2023
Symptom relief for patients with senile hypertension. Asian journal of surgery\| PubMed ID: 37775393	2023
Application of acupuncture in diabetic gastroparesis: A case series. Asian journal of surgery\| PubMed ID: 38036355	2024
Symptom relief for patients with primary dysmenorrhea. Asian journal of surgery\| PubMed ID: 38049348	2024
Non-pharmacologic Chinese-medicine treatment for insomnia in patients with heart failure. Asian journal of surgery\| PubMed ID: 38143168	2024
Clinical application of acupressure in patients with essential hypertension. Asian journal of surgery\| PubMed ID: 38242783	2024

Hui Yan

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