E. Scott Graham

Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway.

Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal!

Cannabinoid Receptors: A brief history and what not.

Detailed characterisation of CB2 receptor protein expression in peripheral blood immune cells from healthy human volunteers using flow cytometry.

Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: implications for therapeutics.

Real-time profiling of NK cell killing of human astrocytes using xCELLigence technology.

Detailed analysis of inflammatory and neuromodulatory cytokine secretion from human NT2 astrocytes using multiplex bead array.

Sensitive and accurate quantification of human leukocyte migration using high-content Discovery-1 imaging system and ATPlite assay.

M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells.

Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFβ1 or M-CSF.

A Cell Derived Active Contour (CDAC) method for robust tracking in low frame rate, low contrast phase microscopy - an example: the human hNT astrocyte.

Exposure to inflammatory cytokines IL-1β and TNFα induces compromise and death of astrocytes; implications for chronic neuroinflammation.

Enrichment of differentiated hNT neurons and subsequent analysis using flow-cytometry and xCELLigence sensing.

Development of positive control tissue for in situ hybridisation using Alvetex scaffolds.

Application of xCELLigence RTCA Biosensor Technology for Revealing the Profile and Window of Drug Responsiveness in Real Time.

Pro-inflammatory TNFα and IL-1β differentially regulate the inflammatory phenotype of brain microvascular endothelial cells.

Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors.

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function.

Cultured pericytes from human brain show phenotypic and functional differences associated with differential CD90 expression.

Plasmin and regulators of plasmin activity control the migratory capacity and adhesion of human T cells and dendritic cells by regulating cleavage of the chemokine CCL21.

Statins Inhibit Fibrillary β-Amyloid Induced Inflammation in a Model of the Human Blood Brain Barrier.

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes.

ECIS technology reveals that monocytes isolated by CD14+ve selection mediate greater loss of BBB integrity than untouched monocytes, which occurs to a greater extent with IL-1β activated endothelium in comparison to TNFα.

Is the Cannabinoid CB Receptor a Major Regulator of the Neuroinflammatory Axis of the Neurovascular Unit in Humans?

Biosensor Technology Reveals the Disruption of the Endothelial Barrier Function and the Subsequent Death of Blood Brain Barrier Endothelial Cells to Sodium Azide and Its Gaseous Products.

The inflammasome pathway is amplified and perpetuated in an autocrine manner through connexin43 hemichannel mediated ATP release.

The Importance of Multifrequency Impedance Sensing of Endothelial Barrier Formation Using ECIS Technology for the Generation of a Strong and Durable Paracellular Barrier.

The functional and inflammatory response of brain endothelial cells to Toll-Like Receptor agonists.

In Vitro Wounding Models Using the Electric Cell-Substrate Impedance Sensing (ECIS)-Zθ Technology.

Real-Time Measurement of Melanoma Cell-Mediated Human Brain Endothelial Barrier Disruption Using Electric Cell-Substrate Impedance Sensing Technology.

Evaluation of parylene derivatives for use as biomaterials for human astrocyte cell patterning.

Large 10  ×  10 single cell grid networks of human hNT astrocytes on raised parylene-C/SiO substrates.

Bradykinin receptor-1 activation induces inflammation and increases the permeability of human brain microvascular endothelial cells.

Cannabinoid Receptor 2 (CB) Signals via G-alpha-s and Induces IL-6 and IL-10 Cytokine Secretion in Human Primary Leukocytes.

Analysis of Melanoma Secretome for Factors That Directly Disrupt the Barrier Integrity of Brain Endothelial Cells.

Geometric micro-shapes facilitate trackless connections between human astrocytes.

Comparison of Leading Biosensor Technologies to Detect Changes in Human Endothelial Barrier Properties in Response to Pro-Inflammatory TNFα and IL1β in Real-Time.

Superior galvanostatic electrochemical deposition of platinum nanograss provides high performance planar microelectrodes forneural recording.

Can ECIS Biosensor Technology Be Used to Measure the Cellular Responses of Glioblastoma Stem Cells?

Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis.

Critical Spatial-Temporal Dynamics and Prominent Shape Collapse of Calcium Waves Observed in Human hNT Astrocytes .

Comprehensive Assessment of Secreted Immuno-Modulatory Cytokines by Serum-Differentiated and Stem-like Glioblastoma Cells Reveals Distinct Differences between Glioblastoma Phenotypes.

Melanoma Cells Produce Large Vesicular-Bodies That Cause Rapid Disruption of Brain Endothelial Barrier-Integrity and Disassembly of Junctional Proteins.

The interaction of placental micro-EVs with immune cells in vivo and in vitro.