Cristian Coarfa

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis.

Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression.

REST represses miR-124 and miR-203 to regulate distinct oncogenic properties of glioblastoma stem cells.

Novel BET protein proteolysis-targeting chimera exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm secondary (s) AML cells.

Regulation of miRNA-29c and its downstream pathways in preneoplastic progression of triple-negative breast cancer.

Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome.

SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein.

Elevated TATA-binding protein expression drives vascular endothelial growth factor expression in colon cancer.

Glutamine Transporters Are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer.

Vitamin D receptor activation reduces VCaP xenograft tumor growth and counteracts ERG activity despite induction of TMPRSS2:ERG.

Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.

miR-130b directly targets ARHGAP1 to drive activation of a metastatic CDC42-PAK1-AP1 positive feedback loop in Ewing sarcoma.

Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder.

Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway.

Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer.

Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy.

A new mild hyperthermia device to treat vascular involvement in cancer surgery.

Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.

Systematic analysis of human telomeric dysfunction using inducible telosome/shelterin CRISPR/Cas9 knockout cells.

Ronin Governs Early Heart Development by Controlling Core Gene Expression Programs.

Distinct TP63 Isoform-Driven Transcriptional Signatures Predict Tumor Progression and Clinical Outcomes.

EWS-FLI1 and RNA helicase A interaction inhibitor YK-4-279 inhibits growth of neuroblastoma.

Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer.

Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis.

Epigenetic supersimilarity of monozygotic twin pairs.

Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies.

ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells.

GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling.

An integrative transcriptomic approach to identify depot differences in genes and microRNAs in adipose tissues from high fat fed mice.

The NIEHS TaRGET II Consortium and environmental epigenomics.

Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas.

Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes.

MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

Mechanisms of skeletal muscle wasting in a mouse model for myotonic dystrophy type 1.

Expression of Long Noncoding RNA Promotes Glycolysis in Breast Cancer.

miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity.

Unbiased Lipidomic Profiling of Triple-Negative Breast Cancer Tissues Reveals the Association of Sphingomyelin Levels with Patient Disease-Free Survival.

Correction: MYCN acts as a direct co-regulator of p53 in MYCN amplified neuroblastoma.

APOBEC mutation drives early-onset squamous cell carcinomas in recessive dystrophic epidermolysis bullosa.

Allele-specific epigenome maps reveal sequence-dependent stochastic switching at regulatory loci.

Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells.

Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.

TGF-β1 programmed myeloid-derived suppressor cells (MDSC) acquire immune-stimulating and tumor killing activity capable of rejecting established tumors in combination with radiotherapy.

The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast.

MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD.

Beyond Autoantibodies: Biologic Roles of Human Autoreactive B Cells in Rheumatoid Arthritis Revealed by RNA-Sequencing.

Correction to: The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast.

The transcription factor POU3F2 regulates a gene coexpression network in brain tissue from patients with psychiatric disorders.

Targeting nuclear β-catenin as therapy for post-myeloproliferative neoplasm secondary AML.

Bacteria-to-Human Protein Networks Reveal Origins of Endogenous DNA Damage.

Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells.

Plasma Urea Cycle Metabolites May Be Useful Biomarkers in Children With Eosinophilic Esophagitis.

DNA Damage Response/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A/C) Mutations.

A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women.

Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy.

Tegavivint and the β-Catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma.

Multi-omics Integration Analysis Robustly Predicts High-Grade Patient Survival and Identifies CPT1B Effect on Fatty Acid Metabolism in Bladder Cancer.

REST-DRD2 mechanism impacts glioblastoma stem cell-mediated tumorigenesis.

Activating p53 family member TAp63: A novel therapeutic strategy for targeting p53-altered tumors.

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1.

Transcriptomic profiling identifies novel mechanisms of transcriptional regulation of the cytochrome P450 (Cyp)3a11 gene.

Cigarette smoke-induced reduction of C1q promotes emphysema.

A genomic atlas of systemic interindividual epigenetic variation in humans.

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression.

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer.

CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†.

Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB).

Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland.

DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism.

Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy.

Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction.

Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.

The testis-specific serine proteases PRSS44, PRSS46, and PRSS54 are dispensable for male mouse fertility†.

The genomic landscape of estrogen receptor α binding sites in mouse mammary gland.

Erratum to "Distinct Lipidomic Landscapes Associated with Clinical Stages of Urothelial Cancer of the Bladder" [Eur Urol Focus 2018;4:907-915].

Loss of the E2 SUMO-conjugating enzyme in oocytes during ovarian folliculogenesis causes infertility in mice.

DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice.

Correction: Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer.

MicroRNA-509-3p inhibits cellular migration, invasion, and proliferation, and sensitizes osteosarcoma to cisplatin.

RNA sequencing-based transcriptome profiling of cardiac tissue implicates novel putative disease mechanisms in FLNC-associated arrhythmogenic cardiomyopathy.

Critical Role of Cytosolic DNA and Its Sensing Adaptor STING in Aortic Degeneration, Dissection, and Rupture.

Long noncoding RNA BHLHE40-AS1 promotes early breast cancer progression through modulating IL-6/STAT3 signaling.

Metabolic dysregulation in the Wilson's disease mouse model.

Hepatic Tumor Formation in Adult Mice Developmentally Exposed to Organotin.

A Phase II Study of Cabozantinib and Androgen Ablation in Patients with Hormone-Naïve Metastatic Prostate Cancer.

Bempegaldesleukin selectively depletes intratumoral Tregs and potentiates T cell-mediated cancer therapy.

Metabolomic biomarkers are associated with mortality in patients with cirrhosis caused by primary biliary cholangitis or primary sclerosing cholangitis.

Mechanistic basis and efficacy of targeting the β-catenin-TCF7L2-JMJD6-c-Myc axis to overcome resistance to BET inhibitors.

Targeting Oncogenic Super Enhancers in MYC-Dependent AML Using a Small Molecule Activator of NR4A Nuclear Receptors.

DNA hypermethylation during tuberculosis dampens host immune responsiveness.

TAp63-Regulated miRNAs Suppress Cutaneous Squamous Cell Carcinoma through Inhibition of a Network of Cell-Cycle Genes.

Spatiotemporal Regulation of ΔNp63 by TGFβ-Regulated miRNAs Is Essential for Cancer Metastasis.

Discovery, Structure-Activity Relationship, and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP.

BCL9/STAT3 regulation of transcriptional enhancer networks promote DCIS progression.

Estrogen receptor-α expressing neurons in the ventrolateral VMH regulate glucose balance.

Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma.

Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood.

Vitamin D actions in neurons require the PI3K pathway for both enhancing insulin signaling and rapid depolarizing effects.

BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C-deficient mice.

Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress.

Identification of cell type-specific methylation signals in bulk whole genome bisulfite sequencing data.

targets gene networks that promote browning of human and mouse adipocytes.

Identification of Genes and Pathways Regulated by Lamin A in Heart.

Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.

Correction: Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression.

Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids.

Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic.

Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection.

STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity.

An actin-WHAMM interaction linking SETD2 and autophagy.

Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation.

Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development.

Haploinsufficiency of Tmem43 in cardiac myocytes activates the DNA damage response pathway leading to a late-onset senescence-associated pro-fibrotic cardiomyopathy.

Targeting PAK4 Inhibits Ras-Mediated Signaling and Multiple Oncogenic Pathways in High-Risk Rhabdomyosarcoma.

RON signalling promotes therapeutic resistance in ESR1 mutant breast cancer.

Isoform-specific Activities of Androgen Receptor and its Splice Variants in Prostate Cancer Cells.

Coagulopathy in Malnourished Mice Is Sexually Dimorphic and Regulated by Nutrient-Sensing Nuclear Receptors.

Hormonal modulation of ESR1 mutant metastasis.

p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma.

Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells.

Constitutive activation of mitogen-activated protein kinase kinase (MEK1) in ileal enterocytes leads to dysplasia and a predisposition to cancer.

Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration.

Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease.

BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma.

A Phase I Dose-Escalation Study to Evaluate the Safety and Tolerability of Evofosfamide in Combination with Ipilimumab in Advanced Solid Malignancies.

A cytoskeletal function for PBRM1 reading methylated microtubules.

Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer.

Author Correction: Androgen receptor and its splice variant, AR-V7, differentially induce mRNA splicing in prostate cancer cells.

Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia.

Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

Neuronal SETD2 activity links microtubule methylation to an anxiety-like phenotype in mice.

Superior efficacy of co-targeting GFI1/KDM1A and BRD4 against AML and post-MPN secondary AML cells.

Reverse-Phase Protein Array: Technology, Application, Data Processing, and Integration.

Perspectives for systems biology in the management of tuberculosis.

Effect of sex chromosomes versus hormones in neonatal lung injury.

A Wnt-Independent LGR4-EGFR Signaling Axis in Cancer Metastasis.

The EP300/TP53 pathway, a suppressor of the Hippo and canonical WNT pathways, is activated in human hearts with arrhythmogenic cardiomyopathy in the absence of overt heart failure.

Early detection of myocardial changes with and without dexrazoxane using serial magnetic resonance imaging in a pre-clinical mouse model.

Esomeprazole enhances the effect of ionizing radiation to improve tumor control.

Effect of substrate stiffness on human intestinal enteroids' infectivity by enteroaggregative Escherichia coli.

Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation.

High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege.

A machine learning case-control classifier for schizophrenia based on DNA methylation in blood.

A noncoding RNA modulator potentiates phenylalanine metabolism in mice.

Memory and naïve gamma delta regulatory T-cell gene expression in the first 24-weeks of peanut oral immunotherapy.

CHAF1A Blocks Neuronal Differentiation and Promotes Neuroblastoma Oncogenesis via Metabolic Reprogramming.

Author Correction: Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells.

Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin.

Inhibition of GATA2 in prostate cancer by a clinically available small molecule.

Tuberculosis endotypes to guide stratified host-directed therapy.

Nuclear S-nitrosylation impacts tissue regeneration in zebrafish.

Single-cell sequencing of rotavirus-infected intestinal epithelium reveals cell-type specific epithelial repair and tuft cell infection.

Correction to: Hormonal modulation of ESR1 mutant metastasis.

miR-181a Promotes Multiple Protumorigenic Functions by Targeting TGFβR3.

Characterization of the COPD alveolar niche using single-cell RNA sequencing.

ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.

Gene expression signatures identify biologically and clinically distinct tuberculosis endotypes.

K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications.

ISA101 and nivolumab for HPV-16 cancer: updated clinical efficacy and immune correlates of response.

Increased DNA methylation, cellular senescence and premature epigenetic aging in guinea pigs and humans with tuberculosis.

Author Correction: ΔNp63 regulates a common landscape of enhancer associated genes in non-small cell lung cancer.

Metabolome and microbiome multi-omics integration from a murine lung inflammation model of bronchopulmonary dysplasia.

Cistrome and transcriptome analysis identifies unique androgen receptor (AR) and AR-V7 splice variant chromatin binding and transcriptional activities.

Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques.

High-throughput profiling of histone post-translational modifications and chromatin modifying proteins by reverse phase protein array.

Calcium/calmodulin-dependent protein kinase kinase 2 regulates hepatic fuel metabolism.

Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer.

MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET.

The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response.

MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma.

Early Systemic Glycolytic Shift After Aneurysmal Subarachnoid Hemorrhage is Associated with Functional Outcomes.

Deletion of the gene in fibroblasts causes senescence-associated dilated cardiomyopathy by activating the double-stranded DNA damage response and induction of senescence-associated secretory phenotype.

Histopathologic and transcriptomic phenotypes of a conditional RANKL transgenic mouse thymus.

Differential co-expression networks of the gut microbiota are associated with depression and anxiety treatment resistance among psychiatric inpatients.

Plasma protein biomarkers for primary graft dysfunction after lung transplantation: a single-center cohort analysis.

Sex-specific epigenetic development in the mouse hypothalamic arcuate nucleus pinpoints human genomic regions associated with body mass index.

The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice.

LncRNA PVT-1 promotes osteosarcoma cancer stem-like properties through direct interaction with TRIM28 and TSC2 ubiquitination.

Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control.

MicroRNA-mRNA networks are dysregulated in opioid use disorder postmortem brain: Further evidence for opioid-induced neurovascular alterations.

PD-L1 translocation to the plasma membrane enables tumor immune evasion through MIB2 ubiquitination.

Modeling Ewing Sarcoma Lung Metastasis.

Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix.

A human stem cell-derived neuronal model of morphine exposure reflects brain dysregulation in opioid use disorder: Transcriptomic and epigenetic characterization of postmortem-derived iPSC neurons.

Patients with Lung Cancer of Different Racial Backgrounds Harbor Distinct Immune Cell Profiles.

Evolution of cisplatin resistance through coordinated metabolic reprogramming of the cellular reductive state.

TRAF4-mediated nonproteolytic ubiquitination of androgen receptor promotes castration-resistant prostate cancer.

Functional genomic analysis of non-canonical DNA regulatory elements of the aryl hydrocarbon receptor.

MYC regulates CSF1 expression via microRNA 17/20a to modulate tumor-associated macrophages in osteosarcoma.

Infant and Adult Human Intestinal Enteroids are Morphologically and Functionally Distinct.

TGFβ signaling links early-life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells.

Loss of cytochrome P450 (CYP)1B1 mitigates hyperoxia response in adult mouse lung by reprogramming metabolism and translation.

Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study.

Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury.

Multiomic Investigations into Lung Health and Disease.

TGFβ signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells.

is a synthetic lethal target in -mutant leukemia cells.

Circadian dysfunction induces NAFLD-related human liver cancer in a mouse model.

Metabolomic Rewiring Promotes Endocrine Therapy Resistance in Breast Cancer.

Human intestinal organoids from Cronkhite-Canada syndrome patients reveal link between serotonin and proliferation.

Adipose Triglyceride Lipase Is a Therapeutic Target in Advanced Prostate Cancer That Promotes Metabolic Plasticity.

D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder.

Genome-wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses.

Distinct Amino Acid Profile Characterizes Youth With or at Risk for Type 2 Diabetes.

Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis.

Identification of an early survival prognostic gene signature for localized osteosarcoma patients.

The Maternal and Infant Environmental Health Riskscape study of perinatal disparities in greater Houston: rationale, study design and participant profiles.

Altered Extracellular Matrix-Related Pathways Accelerate the Transition from Normal to Pre-Fibroid Myometrium in Black Women.

restrains an oncogenic epigenetic circuit in AT2 cells to prevent ectopic formation of fibrogenic transitional cell intermediates and pulmonary fibrosis.

is a synthetic-lethal target in -mutant leukemia cells.

Leveraging Integrated RNA Sequencing to Decipher Adrenomedullin's Protective Mechanisms in Experimental Bronchopulmonary Dysplasia.