Michael T. Longaker

Tissue engineering in cleft palate and other congenital malformations.

Wnt-4 expression is increased in fibroblasts after TGF-beta1 stimulation and during fetal and postnatal wound repair.

FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential state.

Age-dependent residual tensile strains are present in the dura mater of rats.

Functions of vitamin D, retinoic acid, and dexamethasone in mouse adipose-derived mesenchymal cells.

Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signaling.

Novel techniques in hernia repair.

Differential gene expression between juvenile and adult dura mater: a window into what genes play a role in the regeneration of membranous bone.

Cyclophilin C-associated protein is up-regulated during wound healing.

Early-gestation fetal scarless wounds have less lysyl oxidase expression.

Epithelial-mesenchymal transition occurs after epidermal development in mouse skin.

The ethics of innovation in pediatric surgery.

Innovation in surgery: a historical perspective.

Progress and potential for regenerative medicine.

Mannose-6-phosphate, an inhibitor of transforming growth factor-beta, improves range of motion after flexor tendon repair.

Microvascular reconstruction of the pediatric mandible.

Chemical rescue of cleft palate and midline defects in conditional GSK-3beta mice.

Isolation and characterization of posterofrontal/sagittal suture mesenchymal cells in vitro.

Transforming growth factor-beta, Smad, and collagen expression patterns in fetal and adult keratinocytes.

Registering clinical trials in plastic and reconstructive surgery.

Cyclic mechanical strain increases production of regulators of bone healing in cultured murine osteoblasts.

Re: differential effects of FGFR2 mutation in ophthalmologic findings in Apert syndrome.

Keratinocytes modulate fetal and postnatal fibroblast transforming growth factor-beta and Smad expression in co-culture.

Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.

Proposition 71 and CIRM--assessing the return on investment.

Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis.

Refining retinoic acid stimulation for osteogenic differentiation of murine adipose-derived adult stromal cells.

Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells.

Early fetal healing as a model for adult organ regeneration.

Analysis of the material properties of early chondrogenic differentiated adipose-derived stromal cells (ASC) using an in vitro three-dimensional micromass culture system.

Overhealing, underhealing, and skin regeneration: a new perspective on wound healing.

Accelerated bone repair after plasma laser corticotomies.

Noggin suppression enhances in vitro osteogenesis and accelerates in vivo bone formation.

In vitro analysis of transforming growth factor-beta1 inhibition in novel transgenic SBE-luciferase mice.

Increased rate of hair regrowth in mice with constitutive overexpression of Del1.

Hypertrophic scar formation following burns and trauma: new approaches to treatment.

Dura mater-derived FGF-2 mediates mitogenic signaling in calvarial osteoblasts.

In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis.

Increased CCN2 transcription in keloid fibroblasts requires cooperativity between AP-1 and SMAD binding sites.

Live imaging of Smad2/3 signaling in mouse skin wound healing.

Use of organotypic coculture to study keloid biology.

Molecular and cellular characterization of mouse calvarial osteoblasts derived from neural crest and paraxial mesoderm.

Formation of in vitro murine cleft palate by abrogation of fibroblast growth factor signaling.

Applications of an athymic nude mouse model of nonhealing critical-sized calvarial defects.

Confocal laser scanning microscopic analysis of collagen scaffolding patterns in cranial sutures.

Hydrostatic pressure enhances chondrogenic differentiation of human bone marrow stromal cells in osteochondrogenic medium.

Blood-derived small Dot cells reduce scar in wound healing.

Cranial sutures: a brief review.

Current progress in keloid research and treatment.

Current treatment of craniosynostosis and future therapeutic directions.

Molecular mechanisms of FGF-2 inhibitory activity in the osteogenic context of mouse adipose-derived stem cells (mASCs).

Identification of differentially regulated genes in fetal wounds during regenerative repair.

Wound repair and regeneration.

Silva et al: Repair of cranial bone defects with calcium phosphate ceramic implant or autogenous bone graft.

Mesenchymal cells for skeletal tissue engineering.

Proliferation, osteogenic differentiation, and fgf-2 modulation of posterofrontal/sagittal suture-derived mesenchymal cells in vitro.

Dissecting the influence of regional dura mater on cranial suture biology.

Microarray analysis of the role of regional dura mater in cranial suture fate.

Fluid shear stress magnitude, duration, and total applied load regulate gene expression and nitric oxide production in primary calvarial osteoblast cultures.

Cell-based therapies for skeletal regenerative medicine.

Regenerative medicine: the next frontier.

Advances in science and technology: impact on craniofacial surgery.

Presidential address: leadership, teamwork, and SUS brand extension.

Hepatic injury and the kinetics of bone marrow-derived hepatocyte transgene expression.

Differential expression of specific FGF ligands and receptor isoforms during osteogenic differentiation of mouse Adipose-derived Stem Cells (mASCs) recapitulates the in vivo osteogenic pattern.

Cell permeant peptide analogues of the small heat shock protein, HSP20, reduce TGF-beta1-induced CTGF expression in keloid fibroblasts.

Global age-dependent differences in gene expression in response to calvarial injury.

Major deficit in the number of underrepresented minority academic surgeons persists.

Plastic surgery and the society of university surgeons: an expanding relationship.

IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia.

Transforming growth factor-beta1 stimulates chondrogenic differentiation of posterofrontal suture-derived mesenchymal cells in vitro.

Differential effects of TGF-beta1 and TGF-beta3 on chondrogenesis in posterofrontal cranial suture-derived mesenchymal cells in vitro.

Topical lineage-negative progenitor-cell therapy for diabetic wounds (invited discussion).

Cranial osteogenesis and suture morphology in Xenopus laevis: a unique model system for studying craniofacial development.

The role of regional posterior frontal dura mater in the overlying suture morphology.

Aging and diabetes impair the neovascular potential of adipose-derived stromal cells.

Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bones.

Craniofacial autologous fat transfer.

Perspectives in cell-based skeletal tissue.

Pfeiffer syndrome twins: despite improved correction in one twin, growth disturbance results in similar need for subsequent monobloc advancement.

Ethnic diversity remains scarce in academic plastic and reconstructive surgery.

The use of polymer scaffolds in skeletal tissue engineering applications.

Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells.

Tissue harvest by means of suction-assisted or third-generation ultrasound-assisted lipoaspiration has no effect on osteogenic potential of human adipose-derived stromal cells.

Ex vivo model of cranial suture morphogenesis and fate.

Unfolded protein response regulation in keloid cells.

Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion.

Fetal skin wound healing.

Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells.

Bone tissue engineering scaffolds of today and tomorrow.

Pulsed direct current electric fields enhance osteogenesis in adipose-derived stromal cells.

Human skin wounds: a major and snowballing threat to public health and the economy.

Origin matters: differences in embryonic tissue origin and Wnt signaling determine the osteogenic potential and healing capacity of frontal and parietal calvarial bones.

From bedside to bench and back again: technology innovation in plastic surgery.

Bone regeneration and repair.

Discussion. TGF-beta1 RNA interference in mouse primary dura cell culture: downstream effects on TGF receptors, FGF-2, and FGF-R1 mRNA levels.

Interaction of wingless protein (Wnt), transforming growth factor-beta1, and hyaluronan production in fetal and postnatal fibroblasts.

Cyclophilin C-associated protein/Mac-2 binding protein colocalizes with calnexin and regulates the expression of tissue transglutaminase.

Unique modulation of cadherin expression pattern during posterior frontal cranial suture development and closure.

Regenerative medicine: a surgeon's perspective.

Addressing the paucity of underrepresented minorities in academic surgery: can the "Rooney Rule" be applied to academic surgery?

Human adipose-derived stromal cells respond to and elaborate bone morphogenetic protein-2 during in vitro osteogenic differentiation.

Retinoic acid enhances osteogenesis in cranial suture-derived mesenchymal cells: potential mechanisms of retinoid-induced craniosynostosis.

A nonviral minicircle vector for deriving human iPS cells.

Human iPS cell-based therapy: considerations before clinical applications.

Regulation of human adipose-derived stromal cell osteogenic differentiation by insulin-like growth factor-1 and platelet-derived growth factor-alpha.

Sonic Hedgehog influences the balance of osteogenesis and adipogenesis in mouse adipose-derived stromal cells.

The SNaP system: biomechanical and animal model testing of a novel ultraportable negative-pressure wound therapy system.

In vitro effects of direct current electric fields on adipose-derived stromal cells.

Different endogenous threshold levels of Fibroblast Growth Factor-ligands determine the healing potential of frontal and parietal bones.

Highlights of the proceedings from the 13th International Congress of the International Society of Craniofacial Surgery: ISCFS 2009.

Deleterious effects of freezing on osteogenic differentiation of human adipose-derived stromal cells in vitro and in vivo.

Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosis.

Fgf-9 is required for angiogenesis and osteogenesis in long bone repair.

Stem cells.

Human adipose derived stromal cells heal critical size mouse calvarial defects.

Connective tissue growth factor in regulation of RhoA mediated cytoskeletal tension associated osteogenesis of mouse adipose-derived stromal cells.

Opposite spectrum of activity of canonical Wnt signaling in the osteogenic context of undifferentiated and differentiated mesenchymal cells: implications for tissue engineering.

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271.

Commentary.

Elucidating mechanisms of osteogenesis in human adipose-derived stromal cells via microarray analysis.

Divergent modulation of adipose-derived stromal cell differentiation by TGF-beta1 based on species of derivation.

Human adipose-derived stromal cells stimulate autogenous skeletal repair via paracrine Hedgehog signaling with calvarial osteoblasts.

Elastic properties of induced pluripotent stem cells.

Paracrine interaction between adipose-derived stromal cells and cranial suture-derived mesenchymal cells.

Depot-specific variation in the osteogenic and adipogenic potential of human adipose-derived stromal cells.

Tissue engineering in plastic surgery: a review.

So you want to be an innovator?

Discussion: Hes1 is required for the development of craniofacial structures derived from ectomesenchymal neural crest cells.

The diverse surgeons initiative: an effective method for increasing the number of under-represented minorities in academic surgery.

Scarless fetal wound healing: a basic science review.

Engineered pullulan-collagen composite dermal hydrogels improve early cutaneous wound healing.

The basic science of vascular biology: implications for the practicing surgeon.

Basic science review on adipose tissue for clinicians.

Activation of FGF signaling mediates proliferative and osteogenic differences between neural crest derived frontal and mesoderm parietal derived bone.

Meta Analysis of the Effectiveness of Surgical Scalpel or Diathermy in Making Abdominal Skin Incisions.

Surgical approaches to create murine models of human wound healing.

Strategies for organ level tissue engineering.

Salvage of the crucified chin.

The role of stem cells in cutaneous wound healing: what do we really know?

Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors.

Deformational plagiocephaly: a look into the future.

Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cells.

Differential expression of sclerostin in adult and juvenile mouse calvariae.

Diathermy or surgical scalpel for abdominal skin incisions: what is the impact on clinical practice?

In brief: Regenerative medicine.

Regenerative medicine.

Concise review: adipose-derived stromal cells for skeletal regenerative medicine.

Acute skeletal injury is necessary for human adipose-derived stromal cell-mediated calvarial regeneration.

Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection.

Role of Indian hedgehog signaling in palatal osteogenesis.

Research training in plastic surgery.

Osteogenic differentiation of adipose-derived stromal cells in mouse and human: in vitro and in vivo methods.

Osteogenic differentiation of human multipotent mesenchymal stromal cells.

Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation.

Fgf-18 is required for osteogenesis but not angiogenesis during long bone repair.

Integrating cultural competency and humility training into clinical clerkships: surgery as a model.

Indian hedgehog positively regulates calvarial ossification and modulates bone morphogenetic protein signaling.

Improving cutaneous scar formation by controlling the mechanical environment: large animal and phase I studies.

Dura mater stimulates human adipose-derived stromal cells to undergo bone formation in mouse calvarial defects.

Fetal mouse skin heals scarlessly in a chick chorioallantoic membrane model system.

Preclinical derivation and imaging of autologously transplanted canine induced pluripotent stem cells.

An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells.

Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiation.

Pushing back: wound mechanotransduction in repair and regeneration.

Differences in osteogenic differentiation of adipose-derived stromal cells from murine, canine, and human sources in vitro and in vivo.

Recommendations on clinical proof of efficacy for potential scar prevention and reduction therapies.

Craniosynostosis of coronal suture in twist1 mice occurs through endochondral ossification recapitulating the physiological closure of posterior frontal suture.

Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip.

Vascular anastomosis using controlled phase transitions in poloxamer gels.

The angiogenic factor Del1 prevents apoptosis of endothelial cells through integrin binding.

Mechanical force prolongs acute inflammation via T-cell-dependent pathways during scar formation.

Enhancement of human adipose-derived stromal cell angiogenesis through knockdown of a BMP-2 inhibitor.

CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signaling.

Commentary on role of apoptosis in retinoic Acid-induced cleft palate.

Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold.

Palatogenesis: engineering, pathways and pathologies.

Pullulan hydrogels improve mesenchymal stem cell delivery into high-oxidative-stress wounds.

Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repair.

Role of GSK-3β in the osteogenic differentiation of palatal mesenchyme.

Antimycotic ciclopirox olamine in the diabetic environment promotes angiogenesis and enhances wound healing.

Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.

Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells.

A comparative analysis of the osteogenic effects of BMP-2, FGF-2 and VEGFA in a calvarial defect model.

Large Animal Induced Pluripotent Stem Cells as Pre-Clinical Models For Studying Human Disease.

Craniofacial surgery: innovation, design, and strategy.

Cranial suture biology: from pathways to patient care.

Stem cells: update and impact on craniofacial surgery.

Training the contemporary surgeon-scientist.

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy.

Rethinking the blastema.

Comparison of several attachment methods for human iPS, embryonic and adipose-derived stem cells for tissue engineering.

Craniofacial reconstruction with induced pluripotent stem cells.

Stem cell niches for skin regeneration.

Regenerative surgery: tissue engineering in general surgical practice.

Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation.

Soft tissue mechanotransduction in wound healing and fibrosis.

Exogenous Activation of BMP-2 Signaling Overcomes TGFβ-Mediated Inhibition of Osteogenesis in Marfan Embryonic Stem Cells and Marfan Patient Specific Induced-Pluripotent Stem Cells.

Introduction: Wound repair.

Scarless fetal skin wound healing update.