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Jacob S. Lewis

Molecular Horizons and School of Science

University of Wollongong

BIOGRAPHY

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PUBLICATIONS

Single-molecule visualization of fast polymerase turnover in the bacterial replisome.

eLife Apr, 2017 | Pubmed ID: 28432790

Single-molecule visualization of leading-strand synthesis reveals dynamic interaction between MTC and the replisome.

Proceedings of the National Academy of Sciences of the United States of America Oct, 2017 | Pubmed ID: 28923950

Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination.

Trends in biochemical sciences Mar, 2018 | Pubmed ID: 29290471

Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA.

Molecules (Basel, Switzerland) Jan, 2019 | Pubmed ID: 30704053

Spatial and temporal organization of RecA in the DNA-damage response.

eLife Feb, 2019 | Pubmed ID: 30717823

Recycling of single-stranded DNA-binding protein by the bacterial replisome.

Nucleic acids research May, 2019 | Pubmed ID: 30767010

Nuclease dead Cas9 is a programmable roadblock for DNA replication.

Scientific reports Sep, 2019 | Pubmed ID: 31527759

Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication.

Molecular cell Jan, 2020 | Pubmed ID: 31704183

Design of customizable long linear DNA substrates with controlled end modifications for single-molecule studies.

Analytical biochemistry Mar, 2020 | Pubmed ID: 31870680

A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome.

Molecular cell Jul, 2020 | Pubmed ID: 32464091

Replisome bypass of a protein-based R-loop block by Pif1.

Proceedings of the National Academy of Sciences of the United States of America Dec, 2020 | Pubmed ID: 33199603

Production of long linear DNA substrates with site-specific chemical lesions for single-molecule replisome studies.

Methods in enzymology , 2022 | Pubmed ID: 35934481

Embracing Heterogeneity: Challenging the Paradigm of Replisomes as Deterministic Machines.

Chemical reviews Dec, 2023 | Pubmed ID: 37971892

INSTITUTIONS

University of Wollongong

JOVE ARTICLES

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Nicholas Kusi-Appauh¹,

Stefan H. Mueller¹,

Stephen F. Ralph¹,

Olga Yurieva^2,3,

Michael E. O’Donnell^2,3,

Jacob S. Lewis¹,

Lisanne M. Spenkelink¹

¹Molecular Horizons and School of Science, University of Wollongong,

²Howard Hughes Medical Institute, Rockefeller University,

³Laboratory of DNA Replication, Rockefeller University

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Jacob S. Lewis

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Molecular Horizons and School of Science

University of Wollongong

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

Molecular Horizons and School of Science