Jacob S. Lewis

Single-molecule visualization of fast polymerase turnover in the bacterial replisome.

Single-molecule visualization of leading-strand synthesis reveals dynamic interaction between MTC and the replisome.

Resolving the Gordian Knot: Srs2 Strips Intermediates Formed during Homologous Recombination.

Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA.

Spatial and temporal organization of RecA in the DNA-damage response.

Recycling of single-stranded DNA-binding protein by the bacterial replisome.

Nuclease dead Cas9 is a programmable roadblock for DNA replication.

Tunability of DNA Polymerase Stability during Eukaryotic DNA Replication.

Design of customizable long linear DNA substrates with controlled end modifications for single-molecule studies.

A Primase-Induced Conformational Switch Controls the Stability of the Bacterial Replisome.

Replisome bypass of a protein-based R-loop block by Pif1.

Production of long linear DNA substrates with site-specific chemical lesions for single-molecule replisome studies.

Embracing Heterogeneity: Challenging the Paradigm of Replisomes as Deterministic Machines.