Jeffrey C. Hansen

The SIN domain of the histone octamer is essential for intramolecular folding of nucleosomal arrays.

The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states.

New insights into unwrapping DNA from the nucleosome from a single-molecule optical tweezers method.

Phosphorylation of linker histones regulates ATP-dependent chromatin remodeling enzymes.

Conformational dynamics of the chromatin fiber in solution: determinants, mechanisms, and functions.

Quantitative characterization of specific genomic promoters using agarose gel electrophoresis.

Chromatin compaction by human MeCP2. Assembly of novel secondary chromatin structures in the absence of DNA methylation.

Formation of higher-order secondary and tertiary chromatin structures by genomic mouse mammary tumor virus promoters.

Revisiting the structure and functions of the linker histone C-terminal tail domain.

Identification of specific functional subdomains within the linker histone H10 C-terminal domain.

Biophysical analysis of specific genomic loci assembled as chromatin in vivo.

Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability.

Nucleosome and chromatin fiber dynamics.

The histone H1 C-terminal domain binds to the apoptotic nuclease, DNA fragmentation factor (DFF40/CAD) and stimulates DNA cleavage.

The core histone N-terminal tail domains function independently and additively during salt-dependent oligomerization of nucleosomal arrays.

Salt-dependent intra- and internucleosomal interactions of the H3 tail domain in a model oligonucleosomal array.

Intrinsic protein disorder, amino acid composition, and histone terminal domains.

Chromatin architectural proteins.

In vitro chromatin self-association and its relevance to genome architecture.

Developmental biology: holding pattern for histones.

Multiple modes of interaction between the methylated DNA binding protein MeCP2 and chromatin.

Linking genome structure and function through specific histone acetylation.

Domain organization and quaternary structure of the Saccharomyces cerevisiae silent information regulator 3 protein, Sir3p.

The H3 tail domain participates in multiple interactions during folding and self-association of nucleosome arrays.

Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex.

Intrinsic disorder and autonomous domain function in the multifunctional nuclear protein, MeCP2.

Novel mechanism of inhibition of rat kidney-type glutaminase by bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES).

MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome.

A charged and contoured surface on the nucleosome regulates chromatin compaction.

The silent information regulator 3 protein, SIR3p, binds to chromatin fibers and assembles a hypercondensed chromatin architecture in the presence of salt.

The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.

Malleable machines take shape in eukaryotic transcriptional regulation.

Chromatin condensing functions of the linker histone C-terminal domain are mediated by specific amino acid composition and intrinsic protein disorder.

Role of nucleic acid binding in Sir3p-dependent interactions with chromatin fibers.

Recent advances in MeCP2 structure and function.

Determinants of histone H4 N-terminal domain function during nucleosomal array oligomerization: roles of amino acid sequence, domain length, and charge density.

Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.

Structural characterization of H3K56Q nucleosomes and nucleosomal arrays.

Multifunctionality of the linker histones: an emerging role for protein-protein interactions.

Unique physical properties and interactions of the domains of methylated DNA binding protein 2.

Histone chaperones, histone acetylation, and the fluidity of the chromogenome.

Activator-dependent p300 acetylation of chromatin in vitro: enhancement of transcription by disruption of repressive nucleosome-nucleosome interactions.

Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.

Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes.

Nucleosome distribution and linker DNA: connecting nuclear function to dynamic chromatin structure.

Chicken erythrocyte histone octamer preparation.

DNA binding restricts the intrinsic conformational flexibility of methyl CpG binding protein 2 (MeCP2).

The linker region of macroH2A promotes self-association of nucleosomal arrays.

Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini.

Activator-dependent acetylation of chromatin model systems.

Coil-to-helix transitions in intrinsically disordered methyl CpG binding protein 2 and its isolated domains.

Dynamic fuzziness during linker histone action.

Human mitotic chromosome structure: what happened to the 30-nm fibre?

Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus.

The role of the nucleosome acidic patch in modulating higher order chromatin structure.