Karolin Luger

Structure and dynamic properties of nucleosome core particles.

p300-mediated tax transactivation from recombinant chromatin: histone tail deletion mimics coactivator function.

The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational states.

Solvent mediated interactions in the structure of the nucleosome core particle at 1.9 a resolution.

Blocking transcription through a nucleosome with synthetic DNA ligands.

The tail does not always wag the dog.

Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands.

Histone chaperones and nucleosome assembly.

Structure and dynamics of nucleosomal DNA.

Structure and dynamic behavior of nucleosomes.

Tax recruitment of CBP/p300, via the KIX domain, reveals a potent requirement for acetyltransferase activity that is chromatin dependent and histone tail independent.

Preferential binding of the histone (H3-H4)2 tetramer by NAP1 is mediated by the amino-terminal histone tails.

Crystal structures of histone Sin mutant nucleosomes reveal altered protein-DNA interactions.

Reconstitution of nucleosome core particles from recombinant histones and DNA.

A new fluorescence resonance energy transfer approach demonstrates that the histone variant H2AZ stabilizes the histone octamer within the nucleosome.

Molecular recognition of the nucleosomal "supergroove".

Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNA.

Structural determinants for generating centromeric chromatin.

Defined structural changes occur in a nucleosome upon Amt1 transcription factor binding.

Nucleosome assembly protein 1 exchanges histone H2A-H2B dimers and assists nucleosome sliding.

H2A.Z alters the nucleosome surface to promote HP1alpha-mediated chromatin fiber folding.

Nucleosomes in solution exist as a mixture of twist-defect states.

Nucleosome and chromatin fiber dynamics.

The temperature of flash-cooling has dramatic effects on the diffraction quality of nucleosome crystals.

The core histone N-terminal tail domains function independently and additively during salt-dependent oligomerization of nucleosomal arrays.

Structural characterization of the histone variant macroH2A.

The structure of nucleosome assembly protein 1.

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA.

Dynamic nucleosomes.

Kaposi's sarcoma-associated herpesvirus LANA hitches a ride on the chromosome.

The histone variant macro-H2A preferentially forms "hybrid nucleosomes".

A feed-forward repression mechanism anchors the Sin3/histone deacetylase and N-CoR/SMRT corepressors on chromatin.

Nucleosome core particles containing a poly(dA.dT) sequence element exhibit a locally distorted DNA structure.

Structure and function of nucleosome assembly proteins.

Effects of photochemically activated alkylating agents of the FR900482 family on chromatin.

Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer.

A charged and contoured surface on the nucleosome regulates chromatin compaction.

A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1.

Histone chaperones in nucleosome eviction and histone exchange.

A thermodynamic model for Nap1-histone interactions.

The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.

Histone chaperone specificity in Rtt109 activation.

Nucleosome-binding affinity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA.

A positive spin on the centromere.

Structural and biophysical studies of human PARP-1 in complex with damaged DNA.

Methods to characterize the effect of DNA-modifying compounds on nucleosomal DNA.

Structural characterization of H3K56Q nucleosomes and nucleosomal arrays.

Rise of the molecular machines.

The histone chaperone Nap1 promotes nucleosome assembly by eliminating nonnucleosomal histone DNA interactions.

Histone chaperones, histone acetylation, and the fluidity of the chromogenome.

The transcription factor Spn1 regulates gene expression via a highly conserved novel structural motif.

Nucleosome accessibility governed by the dimer/tetramer interface.

A coupled equilibrium approach to study nucleosome thermodynamics.

Biophysical analysis and small-angle X-ray scattering-derived structures of MeCP2-nucleosome complexes.

Nucleosome structure(s) and stability: variations on a theme.

The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization.

The DEK oncoprotein is a Su(var) that is essential to heterochromatin integrity.

The linker region of macroH2A promotes self-association of nucleosomal arrays.

Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomes.

Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini.

Histone chaperone FACT coordinates nucleosome interaction through multiple synergistic binding events.

Understanding histone acetyltransferase Rtt109 structure and function: how many chaperones does it take?

Fluorescence strategies for high-throughput quantification of protein interactions.

Proteins for packaging, partitioning, processing, and proofing of nucleic acids.

New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

Alternative modes of binding of poly(ADP-ribose) polymerase 1 to free DNA and nucleosomes.

Quantifying chromatin-associated interactions: the HI-FI system.

Yeast CAF-1 assembles histone (H3-H4)2 tetramers prior to DNA deposition.

Structure of Actin-related protein 8 and its contribution to nucleosome binding.

Stability of nucleosomes containing homogenously ubiquitylated H2A and H2B prepared using semisynthesis.

Linker histone H1.0 interacts with an extensive network of proteins found in the nucleolus.

The role of the nucleosome acidic patch in modulating higher order chromatin structure.

Evidence for monomeric actin function in INO80 chromatin remodeling.

Histone chaperone FACT action during transcription through chromatin by RNA polymerase II.

Chaperone Nap1 Shields Histone Surfaces Used in a Nucleosome and Can Put H2A-H2B in an Unconventional Tetrameric Form.