Department of Biology
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Acyl-CoA oxidase is imported as a heteropentameric, cofactor-containing complex into peroxisomes of Yarrowia lipolytica.
The Journal of cell biology Feb, 2002 | Pubmed ID: 11815635
RNA interference of peroxisome-related genes in C. elegans: a new model for human peroxisomal disorders.
Physiological genomics Aug, 2002 | Pubmed ID: 12181365
Peroxisome division in the yeast Yarrowia lipolytica is regulated by a signal from inside the peroxisome.
The Journal of cell biology Sep, 2003 | Pubmed ID: 14504266
The peroxisome: orchestrating important developmental decisions from inside the cell.
The Journal of cell biology Mar, 2004 | Pubmed ID: 14981090
A new definition for the consensus sequence of the peroxisome targeting signal type 2.
Journal of molecular biology Jul, 2004 | Pubmed ID: 15312767
Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion.
The Journal of cell biology Feb, 2005 | Pubmed ID: 15738267
Peroxisome biogenesis: the peroxisomal endomembrane system and the role of the ER.
The Journal of cell biology Jul, 2006 | Pubmed ID: 16801391
Lipids and lipid domains in the peroxisomal membrane of the yeast Yarrowia lipolytica.
Biochimica et biophysica acta Dec, 2006 | Pubmed ID: 17023063
Overproduction of translation elongation factor 1-alpha (eEF1A) suppresses the peroxisome biogenesis defect in a Hansenula polymorpha pex3 mutant via translational read-through.
FEMS yeast research Oct, 2007 | Pubmed ID: 17425673
A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membrane.
The Journal of cell biology Apr, 2007 | Pubmed ID: 17438077
Spatiotemporal dynamics of the ER-derived peroxisomal endomembrane system.
International review of cell and molecular biology , 2009 | Pubmed ID: 19121819
Effect of calorie restriction on the metabolic history of chronologically aging yeast.
Experimental gerontology Sep, 2009 | Pubmed ID: 19539741
A novel function of lipid droplets in regulating longevity.
Biochemical Society transactions Oct, 2009 | Pubmed ID: 19754450
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.
Aging Jul, 2010 | Pubmed ID: 20622262
Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.
Aging Aug, 2010 | Pubmed ID: 20693605
Peroxisome metabolism and cellular aging.
Traffic (Copenhagen, Denmark) Mar, 2011 | Pubmed ID: 21083858
In search of housekeeping pathways that regulate longevity.
Cell cycle (Georgetown, Tex.) Sep, 2011 | Pubmed ID: 21862878
Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells.
Oncotarget Oct, 2011 | Pubmed ID: 21992775
Dynamics and regulation of lipid droplet formation in lipopolysaccharide (LPS)-stimulated microglia.
Biochimica et biophysica acta Jan, 2012 | Pubmed ID: 22289388
Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms.
Dose-response : a publication of International Hormesis Society , 2012 | Pubmed ID: 22423230
Caloric restriction extends yeast chronological lifespan by altering a pattern of age-related changes in trehalose concentration.
Frontiers in physiology , 2012 | Pubmed ID: 22783207
Lithocholic acid extends longevity of chronologically aging yeast only if added at certain critical periods of their lifespan.
Cell cycle (Georgetown, Tex.) Sep, 2012 | Pubmed ID: 22894934
Integration of peroxisomes into an endomembrane system that governs cellular aging.
Frontiers in physiology , 2012 | Pubmed ID: 22936916
The spatiotemporal dynamics of longevity-defining cellular processes and its modulation by genetic, dietary, and pharmacological anti-aging interventions.
Frontiers in physiology , 2012 | Pubmed ID: 23118730
Macromitophagy is a longevity assurance process that in chronologically aging yeast limited in calorie supply sustains functional mitochondria and maintains cellular lipid homeostasis.
Aging Apr, 2013 | Pubmed ID: 23553280
A network of interorganellar communications underlies cellular aging.
IUBMB life Aug, 2013 | Pubmed ID: 23818261
Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity.
Sub-cellular biochemistry , 2013 | Pubmed ID: 23821148
Mitochondrial membrane lipidome defines yeast longevity.
Aging Jul, 2013 | Pubmed ID: 23924582
Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells.
PeerJ , 2013 | Pubmed ID: 23940835
Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from "liponecrosis", a previously unknown form of programmed cell death.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 24196447
Cells with impaired mitochondrial H2O2 sensing generate less •OH radicals and live longer.
Antioxidants & redox signaling Oct, 2014 | Pubmed ID: 24382195
A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology.
Redox biology , 2014 | Pubmed ID: 24563847
Metabolomic and lipidomic analyses of chronologically aging yeast.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 25213255
Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid.
International journal of molecular sciences Sep, 2014 | Pubmed ID: 25238416
Mechanism of liponecrosis, a distinct mode of programmed cell death.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 25483081
Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan.
Cell cycle (Georgetown, Tex.) , 2014 | Pubmed ID: 25485579
Origin and spatiotemporal dynamics of the peroxisomal endomembrane system.
Frontiers in physiology , 2014 | Pubmed ID: 25566090
The Intricate Interplay between Mechanisms Underlying Aging and Cancer.
Aging and disease Feb, 2015 | Pubmed ID: 25657853
Mechanisms by which different functional states of mitochondria define yeast longevity.
International journal of molecular sciences Mar, 2015 | Pubmed ID: 25768339
Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.
Cell cycle (Georgetown, Tex.) , 2015 | Pubmed ID: 25839782
Longevity extension by phytochemicals.
Molecules (Basel, Switzerland) Apr, 2015 | Pubmed ID: 25871373
A novel approach to the discovery of anti-tumor pharmaceuticals: searching for activators of liponecrosis.
Oncotarget Feb, 2016 | Pubmed ID: 26636650
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Cell-Nonautonomous Mechanisms Underlying Cellular and Organismal Aging.
International review of cell and molecular biology , 2016 | Pubmed ID: 26811290
Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes.
Oncotarget Mar, 2016 | Pubmed ID: 26918729
Mitochondria operate as signaling platforms in yeast aging.
Aging Feb, 2016 | Pubmed ID: 26928478
Six plant extracts delay yeast chronological aging through different signaling pathways.
Oncotarget Aug, 2016 | Pubmed ID: 27447556
Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging.
Frontiers in genetics , 2016 | Pubmed ID: 27729926
Empirical verification of evolutionary theories of aging.
Aging 10, 2016 | Pubmed ID: 27783562
Lithocholic acid induces endoplasmic reticulum stress, autophagy and mitochondrial dysfunction in human prostate cancer cells.
PeerJ , 2016 | Pubmed ID: 27896021
Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms.
Frontiers in genetics , 2016 | Pubmed ID: 27999589
A laboratory test of evolutionary aging theories.
Aging 03, 2017 | Pubmed ID: 28325887
Cell-autonomous mechanisms of chronological aging in the yeast .
Microbial cell (Graz, Austria) May, 2014 | Pubmed ID: 28357241
Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast.
Oncotarget May, 2017 | Pubmed ID: 28410198
Mechanisms Underlying the Essential Role of Mitochondrial Membrane Lipids in Yeast Chronological Aging.
Oxidative medicine and cellular longevity , 2017 | Pubmed ID: 28593023
Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK).
Cellular signalling 12, 2017 | Pubmed ID: 28923415
Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae.
Frontiers in bioscience (Landmark edition) Jan, 2018 | Pubmed ID: 28930594
Caloric restriction extends yeast chronological lifespan via a mechanism linking cellular aging to cell cycle regulation, maintenance of a quiescent state, entry into a non-quiescent state and survival in the non-quiescent state.
Oncotarget Sep, 2017 | Pubmed ID: 29050207
Some Metabolites Act as Second Messengers in Yeast Chronological Aging.
International journal of molecular sciences Mar, 2018 | Pubmed ID: 29543708
Yeast Cells Exposed to Exogenous Palmitoleic Acid Either Adapt to Stress and Survive or Commit to Regulated Liponecrosis and Die.
Oxidative medicine and cellular longevity , 2018 | Pubmed ID: 29636840
Caloric restriction delays yeast chronological aging by remodeling carbohydrate and lipid metabolism, altering peroxisomal and mitochondrial functionalities, and postponing the onsets of apoptotic and liponecrotic modes of regulated cell death.
Oncotarget Mar, 2018 | Pubmed ID: 29662634
Yeast chronological aging is linked to cell cycle regulation.
Cell cycle (Georgetown, Tex.) , 2018 | Pubmed ID: 29895227
Molecular and Cellular Mechanisms of Aging and Age-related Disorders.
International journal of molecular sciences Jul, 2018 | Pubmed ID: 30011889
Mechanisms through which lithocholic acid delays yeast chronological aging under caloric restriction conditions.
Oncotarget Oct, 2018 | Pubmed ID: 30405886
Pairwise combinations of chemical compounds that delay yeast chronological aging through different signaling pathways display synergistic effects on the extent of aging delay.
Oncotarget Jan, 2019 | Pubmed ID: 30719227
Quiescence Entry, Maintenance, and Exit in Adult Stem Cells.
International journal of molecular sciences May, 2019 | Pubmed ID: 31052375
Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla.
Frontiers in physiology , 2019 | Pubmed ID: 31057428
Aging and Age-related Disorders: From Molecular Mechanisms to Therapies.
International journal of molecular sciences Jul, 2019 | Pubmed ID: 31277345
Mechanisms by which PE21, an extract from the white willow , delays chronological aging in budding yeast.
Oncotarget Oct, 2019 | Pubmed ID: 31645900
Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast.
Oncotarget Jun, 2020 | Pubmed ID: 32577164
Mechanisms that Link Chronological Aging to Cellular Quiescence in Budding Yeast.
International journal of molecular sciences Jul, 2020 | Pubmed ID: 32630624
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