Pharmacology and Toxicology
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Prolonged reversal of morphine tolerance with no reversal of dependence by protein kinase C inhibitors.
Brain research Dec, 2002 | Pubmed ID: 12468027
The expression of a high level of morphine antinociceptive tolerance in mice involves both PKC and PKA.
Brain research Sep, 2003 | Pubmed ID: 12957370
Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice.
European journal of pharmacology May, 2004 | Pubmed ID: 15178357
PKC and PKA inhibitors reverse tolerance to morphine-induced hypothermia and supraspinal analgesia in mice.
European journal of pharmacology May, 2004 | Pubmed ID: 15178359
Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice.
European journal of pharmacology Mar, 2005 | Pubmed ID: 15740725
Alterations in brain Protein Kinase A activity and reversal of morphine tolerance by two fragments of native Protein Kinase A inhibitor peptide (PKI).
Neuropharmacology Apr, 2005 | Pubmed ID: 15814100
Chronic Delta9-tetrahydrocannabinol treatment produces antinociceptive tolerance in mice without altering protein kinase A activity in mouse brain and spinal cord.
Biochemical pharmacology Jul, 2005 | Pubmed ID: 15913565
Protein Kinase A activity is increased in mouse lumbar spinal cord but not brain following morphine antinociceptive tolerance for 15 days.
Pharmacological research : the official journal of the Italian Pharmacological Society Sep, 2005 | Pubmed ID: 16026714
Protein kinase inhibitor peptide (PKI): a family of endogenous neuropeptides that modulate neuronal cAMP-dependent protein kinase function.
Neuropeptides Feb, 2006 | Pubmed ID: 16442618
Pharmacological characterization of novel water-soluble cannabinoids.
The Journal of pharmacology and experimental therapeutics Sep, 2006 | Pubmed ID: 16757541
Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice.
Pain Jan, 2007 | Pubmed ID: 16965856
How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance?
Trends in pharmacological sciences Nov, 2006 | Pubmed ID: 17000011
PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.
Pharmacological research : the official journal of the Italian Pharmacological Society Dec, 2006 | Pubmed ID: 17056270
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia.
The Journal of pharmacology and experimental therapeutics Jul, 2007 | Pubmed ID: 17405869
Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine.
Journal of medicinal chemistry Jul, 2007 | Pubmed ID: 17569516
Evidence for an important role of protein phosphatases in the mechanism of morphine tolerance.
Brain research Jul, 2007 | Pubmed ID: 17582387
mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo.
Brain research Jan, 2008 | Pubmed ID: 18022146
Local production of O2- by NAD(P)H oxidase in the sarcoplasmic reticulum of coronary arterial myocytes: cADPR-mediated Ca2+ regulation.
Cellular signalling Apr, 2008 | Pubmed ID: 18207366
Pre-treatment with a PKC or PKA inhibitor prevents the development of morphine tolerance but not physical dependence in mice.
Brain research Jun, 2008 | Pubmed ID: 18501877
Morphine tolerance in the mouse ileum and colon.
The Journal of pharmacology and experimental therapeutics Nov, 2008 | Pubmed ID: 18682567
Formation and function of ceramide-enriched membrane platforms with CD38 during M1-receptor stimulation in bovine coronary arterial myocytes.
American journal of physiology. Heart and circulatory physiology Oct, 2008 | Pubmed ID: 18723763
Design, synthesis, and biological evaluation of 6alpha- and 6beta-N-heterocyclic substituted naltrexamine derivatives as mu opioid receptor selective antagonists.
Journal of medicinal chemistry Mar, 2009 | Pubmed ID: 19199782
Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice.
Brain research Jun, 2010 | Pubmed ID: 20380816
Role of CD38, a cyclic ADP-ribosylcyclase, in morphine antinociception and tolerance.
The Journal of pharmacology and experimental therapeutics Sep, 2010 | Pubmed ID: 20551293
μ-opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization.
Molecular pharmacology Oct, 2010 | Pubmed ID: 20647394
Chronic neuropathic pain in mice reduces μ-opioid receptor-mediated G-protein activity in the thalamus.
Brain research Aug, 2011 | Pubmed ID: 21762883
The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract.
The Journal of pharmacology and experimental therapeutics Mar, 2012 | Pubmed ID: 22129596
Opioid-induced hypernociception is associated with hyperexcitability and altered tetrodotoxin-resistant Na+ channel function of dorsal root ganglia.
American journal of physiology. Cell physiology Apr, 2012 | Pubmed ID: 22189556
Differences in the characteristics of tolerance to μ-opioid receptor agonists in the colon from wild type and β-arrestin2 knockout mice.
European journal of pharmacology Jun, 2012 | Pubmed ID: 22521552
Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice.
European journal of pharmacology Aug, 2012 | Pubmed ID: 22659585
6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists.
Bioorganic & medicinal chemistry letters Jul, 2012 | Pubmed ID: 22683223
Production and actions of the anandamide metabolite prostamide E2 in the renal medulla.
The Journal of pharmacology and experimental therapeutics Sep, 2012 | Pubmed ID: 22685343
Evidence for the putative cannabinoid receptor (GPR55)-mediated inhibitory effects on intestinal contractility in mice.
Pharmacology , 2012 | Pubmed ID: 22759743
Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.
ACS chemical neuroscience Jul, 2011 | Pubmed ID: 22816021
Contribution of acid sphingomyelinase in the periaqueductal gray region to morphine-induced analgesia in mice.
Neuroreport Sep, 2012 | Pubmed ID: 22825003
Morphine decreases enteric neuron excitability via inhibition of sodium channels.
PloS one , 2012 | Pubmed ID: 23028881
Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.
Journal of medicinal chemistry Nov, 2012 | Pubmed ID: 23116124
Electrophysiological characteristics of enteric neurons isolated from the immortomouse.
Digestive diseases and sciences Jun, 2013 | Pubmed ID: 23371009
Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons.
Molecular pharmacology Aug, 2013 | Pubmed ID: 23716621
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