Chung Wong

Protein flexibility and computer-aided drug design.

Association of the SULT1A1 R213H polymorphism with colorectal cancer.

Designing specific protein kinase inhibitors: insights from computer simulations and comparative sequence/structure analysis.

E2F modulates keratinocyte squamous differentiation: implications for E2F inhibition in squamous cell carcinoma.

A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors.

Brownian dynamics simulation of helix-capping motifs.

Brownian dynamics simulations of ion atmospheres around polyalanine and B-DNA: effects of biomolecular dielectric.

Protein simulation and drug design.

Charge optimization of the interface between protein kinases and their ligands.

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

AP-2 transcription factor family member expression, activity, and regulation in human epidermal keratinocytes in vitro.

E2F6: a member of the E2F family that does not modulate squamous differentiation.

Finite concentration effects on diffusion-controlled reactions.

Release of ADP from the catalytic subunit of protein kinase A: a molecular dynamics simulation study.

E2F suppression and Sp1 overexpression are sufficient to induce the differentiation-specific marker, transglutaminase type 1, in a squamous cell carcinoma cell line.

Relative contributions of desolvation, inter- and intramolecular interactions to binding affinity in protein kinase systems.

Exploiting novel cell cycle targets in the development of anticancer agents.

Laparoscopy compared with laparotomy for the surgical staging of endometrial carcinoma.

Direct estimation of entropy loss due to reduced translational and rotational motions upon molecular binding.

Is it necessary to catheterise the bladder routinely before gynaecological laparoscopic surgery?

Molecular docking of balanol to dynamics snapshots of protein kinase A.

Calculation of solvation free energy from quantum mechanical charge density and continuum dielectric theory.

Molecular dynamics simulation of laser desorption of a fragment of protein kinase A from two MALDI matrices.

Sevoflurane-induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils.

Rank-ordering protein-ligand binding affinity by a quantum mechanics/molecular mechanics/Poisson-Boltzmann-surface area model.

Theoretical studies of the effect of the dipolar field in multiple spin-echo sequences with refocusing pulses of finite duration.

Polycomb group protein RING1B is a direct substrate of Caspases-3 and -9.

Synthetic musk fragrances in human milk from the United States.

The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells.

A mining minima approach to exploring the docking pathways of p-nitrocatechol sulfate to YopH.

Flexible protein-flexible ligand docking with disrupted velocity simulated annealing.

Polybrominated diphenyl ethers and organochlorine pesticides in human breast milk from Massachusetts, USA.

Flexible ligand-flexible protein docking in protein kinase systems.

MicroRNA-26a targets the histone methyltransferase Enhancer of Zeste homolog 2 during myogenesis.

Perfluorinated compounds in human milk from Massachusetts, U.S.A.

Variable atomic radii for continuum-solvent electrostatics calculation.

A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis.

Conformational selection of protein kinase A revealed by flexible-ligand flexible-protein docking.

A computational study of the phosphorylation mechanism of the insulin receptor tyrosine kinase.

Beyond thermodynamics: drug binding kinetics could influence epidermal growth factor signaling.

Docking flexible peptide to flexible protein by molecular dynamics using two implicit-solvent models: an evaluation in protein kinase and phosphatase systems.

Theoretical analysis of the sensitivity of dipolar field signal to local field variations by perturbative expansion of the magnetization.

Derivatives of salicylic acid as inhibitors of YopH in Yersinia pestis.

Quantitative analysis of promoter methylation in exfoliated epithelial cells isolated from breast milk of healthy women.

Promising multiple-epitope recombinant vaccine against foot-and-mouth disease virus type O in swine.

A review on the formation of titania nanotube photocatalysts by hydrothermal treatment.

Influence of kinetics of drug binding on EGFR signaling: a comparative study of three EGFR signaling pathway models.

Suppression of adaptive immunity to heterologous antigens by SJ16 of Schistosoma japonicum.

A case study of scoring and rescoring in peptide docking.

Human dendritic cells engineered to secrete interleukin-18 activate MAGE-A3-specific cytotoxic T lymphocytes in vitro.

Cell survival, DNA damage, and oncogenic transformation after a transient and reversible apoptotic response.

Simulation reveals two major docking pathways between the hexapeptide GDYMNM and the catalytic domain of the insulin receptor protein kinase.

Coiled-coil peptide based sensor for ultra-sensitive thrombin detection.