Daniela Verthelyi

Use of CpG oligodeoxynucleotides as immune adjuvants.

CpG oligodeoxynucleotides as vaccine adjuvants in primates.

Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide.

CpG DNA: recognition by and activation of monocytes.

CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells.

Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides.

CpG oligodeoxynucleotides protect normal and SIV-infected macaques from Leishmania infection.

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis.

Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides.

Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability.

Differential signaling by CpG DNA in DCs and B cells: not just TLR9.

Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates.

CpG oligodeoxynucleotides improve the response to hepatitis B immunization in healthy and SIV-infected rhesus macaques.

Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs.

Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs.

Design and development of thermolytic DNA oligonucleotide prodrugs.

Female's heightened immune status: estrogen, T cells, and inducible nitric oxide synthase in the balance.

CpG oligodeoxynucleotides protect newborn mice from a lethal challenge with the neurotropic Tacaribe arenavirus.

Adjuvant properties of CpG oligonucleotides in primates.

Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates.

GM-CSF production by autoreactive T cells is required for the activation of microglial cells and the onset of experimental autoimmune encephalomyelitis.

Synthetic CpG oligodeoxynucleotides augment BAFF- and APRIL-mediated immunoglobulin secretion.

The IP10 (CXCL10) specific cDNA probe of the mCK-5c multiprobe RNase protection assay kit carries two nucleotide insertions that complicate the interpretation of results.

Immunotherapy with CpG oligonucleotides and antibodies to TNF-alpha rescues neonatal mice from lethal arenavirus-induced meningoencephalitis.

Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment.

Overlooking subvisible particles in therapeutic protein products: gaps that may compromise product quality.

Inhibition of Taq polymerase as a method for screening heparin for oversulfated contaminants.

TLRs as therapeutic targets in CNS inflammation and infection.

High-throughput real-time PCR for early detection and quantitation of arenavirus Tacaribe.

Expression and regulation in the brain of the chemokine CCL27 gene locus.

Trace levels of innate immune response modulating impurities (IIRMIs) synergize to break tolerance to therapeutic proteins.

The acceleration of wound healing in primates by the local administration of immunostimulatory CpG oligonucleotides.

TLR9 and TLR7 agonists mediate distinct type I IFN responses in humans and nonhuman primates in vitro and in vivo.

Mucosal and peripheral Lin- HLA-DR+ CD11c/123- CD13+ CD14- mononuclear cells are preferentially infected during acute simian immunodeficiency virus infection.

Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent.

Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domain.

Regulatory T cells in γ irradiation-induced immune suppression.

Managing uncertainty: a perspective on risk pertaining to product quality attributes as they bear on immunogenicity of therapeutic proteins.

High-throughput quantitative real-time polymerase chain reaction array for absolute and relative quantification of rhesus macaque types I, II, and III interferon and their subtypes.

Scientific considerations in the review and approval of generic enoxaparin in the United States.

Assessment of the cellular internalization of thermolytic phosphorothioate DNA oligonucleotide prodrugs.

Glycosylation, hypogammaglobulinemia, and resistance to viral infections.

Immunology careers at the NIH, FDA and CDC: different paths that focus on advancing public health.