Irving L. Weissman

Evolution of a protochordate allorecognition locus.

Plasticity of adult stem cells.

Circulation and chemotaxis of fetal hematopoietic stem cells.

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium.

Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9.

Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host disease.

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML.

Telomerase maintained in self-renewing tissues during serial regeneration of the urochordate Botryllus schlosseri.

JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.

Isolation of adult mouse myogenic progenitors: functional heterogeneity of cells within and engrafting skeletal muscle.

Frizzled 9 knock-out mice have abnormal B-cell development.

Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration.

Determinants of skeletal muscle contributions from circulating cells, bone marrow cells, and hematopoietic stem cells.

Chronic versus acute myelogenous leukemia: a question of self-renewal.

Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system.

Developmental origin of interferon-alpha-producing dendritic cells from hematopoietic precursors.

Rejuvenation of aged progenitor cells by exposure to a young systemic environment.

Cancer stem cells in solid tumors.

Enforced Bcl-2 expression overrides serum and feeder cell requirements for mouse embryonic stem cell self-renewal.

Selection of aberrant class II restricted CD8+ T cells in NOD mice expressing a glutamic acid decarboxylase (GAD)65-specific T cell receptor transgene.

Stimulation of paracrine pathways with growth factors enhances embryonic stem cell engraftment and host-specific differentiation in the heart after ischemic myocardial injury.

Hematopoietic cells maintain hematopoietic fates upon entering the brain.

Cell intrinsic alterations underlie hematopoietic stem cell aging.

Identification of mast cell progenitors in adult mice.

Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982.

Normal and neoplastic stem cells.

Simple and efficient isolation of hematopoietic stem cells from H2K-zFP transgenic mice.

Differential amplification of murine bipotent megakaryocytic/erythroid progenitor and precursor cells during recovery from acute and chronic erythroid stress.

Differential expression of novel potential regulators in hematopoietic stem cells.

Stepwise development of committed progenitors in the bone marrow that generate functional T cells in the absence of the thymus.

Identification of a novel gene involved in asexual organogenesis in the budding ascidian Botryllus schlosseri.

Flk2+ myeloid progenitors are the main source of Langerhans cells.

Isolation and characterization of a protochordate histocompatibility locus.

Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates.

Differential expression of alpha2 integrin separates long-term and short-term reconstituting Lin-/loThy1.1(lo)c-kit+ Sca-1+ hematopoietic stem cells.

Stem cells are units of natural selection in a colonial ascidian.

Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning.

Antagonistic effect of CCAAT enhancer-binding protein-alpha and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors.

Medicine: politic stem cells.

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery.

Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells.

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation.

Pten, tumorigenesis, and stem cell self-renewal.

Rapid lymphocyte reconstitution of unconditioned immunodeficient mice with non-self-renewing multipotent hematopoietic progenitors.

A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983.

fester, A candidate allorecognition receptor from a primitive chordate.

New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.

Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.

Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.

Clonal analysis of mouse development reveals a polyclonal origin for yolk sac blood islands.

The cancer stem cell hypothesis: a work in progress.

Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR.

Hematopoietic stem cells: expression profiling and beyond.

Hematopoietic reconstitution by multipotent adult progenitor cells: precursors to long-term hematopoietic stem cells.

B-cell development fails in the absence of the Pbx1 proto-oncogene.

Ethics. The ISSCR guidelines for human embryonic stem cell research.

Hematopoietic stem cell aging: mechanism and consequence.

Striving for normality: whole body regeneration through a series of abnormal generations.

Molecular imaging of embryonic stem cell misbehavior and suicide gene ablation.

Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells.

Reversal of autoimmune disease in lupus-prone New Zealand black/New Zealand white mice by nonmyeloablative transplantation of purified allogeneic hematopoietic stem cells.

Stem cells: blood lines from embryo to adult.

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age.

CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia.

Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes.

Pioneer factor interactions and unmethylated CpG dinucleotides mark silent tissue-specific enhancers in embryonic stem cells.

Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis.

Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging.

Transcriptional instability is not a universal attribute of aging.

The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.

Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation.

The effect of bleeding on hematopoietic stem cell cycling and self-renewal.

Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches.

SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity.

Hematopoietic stem cell-derived pericytic cells in brain tumor angio-architecture.

Stems cells and the pathways to aging and cancer.

Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy.

Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood.

Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages.

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth.

Generation of a monoclonal antibody library against human embryonic stem cells.

Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors.

Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation.

The E. Donnall Thomas lecture: normal and neoplastic stem cells.

Space-time considerations for hematopoietic stem cell transplantation.

Hematopoietic stem cells and the aging hematopoietic system.

Reductive isolation from bone marrow and blood implicates common lymphoid progenitors as the major source of thymopoiesis.

Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family.

Identification of the endostyle as a stem cell niche in a colonial chordate.

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes.

The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.

Multimodal evaluation of in vivo magnetic resonance imaging of myocardial restoration by mouse embryonic stem cells.

Wnt-mediated self-renewal of neural stem/progenitor cells.

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival.

In vivo serial evaluation of superparamagnetic iron-oxide labeled stem cells by off-resonance positive contrast.

Cancer stem cell-directed therapies: recent data from the laboratory and clinic.

The adhesion molecule esam1 is a novel hematopoietic stem cell marker.

Endochondral ossification is required for haematopoietic stem-cell niche formation.

Two-step oligoclonal development of male germ cells.

In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood.

E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.

Association of reactive oxygen species levels and radioresistance in cancer stem cells.

Dysregulated gene expression networks in human acute myelogenous leukemia stem cells.

Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells.

Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche.

Automated microfluidic chromatin immunoprecipitation from 2,000 cells.

Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development.

Manganese-guided cellular MRI of human embryonic stem cell and human bone marrow stromal cell viability.

Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150.

A neurosurgeon's guide to stem cells, cancer stem cells, and brain tumor stem cells.

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis.

CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.

Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells.

Neuroprotection of host cells by human central nervous system stem cells in a mouse model of infantile neuronal ceroid lipofuscinosis.

Hematopoietic stem and progenitor cells and the inflammatory response.

Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros.

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.

Niche recycling through division-independent egress of hematopoietic stem cells.

Differential contribution of chemotaxis and substrate restriction to segregation of immature and mature thymocytes.

Functional and transcriptional characterization of human embryonic stem cell-derived endothelial cells for treatment of myocardial infarction.

Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.

microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia.

MiDReG: a method of mining developmentally regulated genes using Boolean implications.

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion.

Coronary arteries form by developmental reprogramming of venous cells.

Distinguishing mast cell and granulocyte differentiation at the single-cell level.

Macrophages as mediators of tumor immunosurveillance.

Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement.

Human melanoma-initiating cells express neural crest nerve growth factor receptor CD271.

Patients beware: commercialized stem cell treatments on the web.

Differential DNA damage response in stem and progenitor cells.

Position-dependent silencing of germline Vß segments on TCRß alleles containing preassembled VßDJßCß1 genes.

The origin and fate of yolk sac hematopoiesis: application of chimera analyses to developmental studies.

Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma.

Hematopoietic stem cell: self-renewal versus differentiation.

Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?

T-cell receptor-driven lymphomagenesis in mice derived from a reprogrammed T cell.

MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets.

In vitro assays misrepresent in vivo lineage potentials of murine lymphoid progenitors.

IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ.

Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia.

Calreticulin is the dominant pro-phagocytic signal on multiple human cancers and is counterbalanced by CD47.

VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration.

Purified hematopoietic stem cell transplantation: the next generation of blood and immune replacement.

Human acute myelogenous leukemia stem cells revisited: there's more than meets the eye.

50 years later: remembering the paper.

Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors.

Frequency of cells expressing CD44, a head and neck cancer stem cell marker: correlation with tumor aggressiveness.

Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.

Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma.

Prospective separation of normal and leukemic stem cells based on differential expression of TIM3, a human acute myeloid leukemia stem cell marker.

Long-term outcome of patients with metastatic breast cancer treated with high-dose chemotherapy and transplantation of purified autologous hematopoietic stem cells.

Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome.

Enhanced survival of pluripotent stem cells under stressful conditions.

Extranodal dissemination of non-Hodgkin lymphoma requires CD47 and is inhibited by anti-CD47 antibody therapy.

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells.

Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip.

Novel hematopoietic progenitor populations revealed by direct assessment of GATA1 protein expression and cMPL signaling events.

Identification of the earliest natural killer cell-committed progenitor in murine bone marrow.

Tracking single hematopoietic stem cells in vivo using high-throughput sequencing in conjunction with viral genetic barcoding.

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

Programmed cell removal: a new obstacle in the road to developing cancer.

The safety of embryonic stem cell therapy relies on teratoma removal.

Three differentiation states risk-stratify bladder cancer into distinct subtypes.

The CD47-SIRPα pathway in cancer immune evasion and potential therapeutic implications.

Perturbation of the hematopoietic system during embryonic liver development due to disruption of polyubiquitin gene Ubc in mice.

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors.

Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma.

Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen.

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells.

Gene Expression Commons: an open platform for absolute gene expression profiling.

Remodeling of endogenous mammary epithelium by breast cancer stem cells.

Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.

The road to purified hematopoietic stem cell transplants is paved with antibodies.

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors.

Human neural stem cells induce functional myelination in mice with severe dysmyelination.

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs, and their vasculature.

In vivo directed differentiation of pluripotent stem cells for skeletal regeneration.

Flipping the script on macrophages in leiomyosarcoma.

E. Donnall Thomas (1920-2012).

Repeated, long-term cycling of putative stem cells between niches in a basal chordate.

Anti-KIT monoclonal antibody inhibits imatinib-resistant gastrointestinal stromal tumor growth.

Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes.

Prospective isolation of human embryonic stem cell-derived cardiovascular progenitors that integrate into human fetal heart tissue.

Synthesis of a photocaged tamoxifen for light-dependent activation of Cre-ER recombinase-driven gene modification.

Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.

Engineered SIRPα variants as immunotherapeutic adjuvants to anticancer antibodies.

Immunogenicity of in vitro maintained and matured populations: potential barriers to engraftment of human pluripotent stem cell derivatives.

Brain tumor stem cell multipotency correlates with nanog expression and extent of passaging in human glioblastoma xenografts.

The genome sequence of the colonial chordate, Botryllus schlosseri.

Clonal precursor of bone, cartilage, and hematopoietic niche stromal cells.

Identification of a colonial chordate histocompatibility gene.

Use of a KIT-specific monoclonal antibody to bypass imatinib resistance in gastrointestinal stromal tumors.

Tumorigenicity as a clinical hurdle for pluripotent stem cell therapies.

Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips.

BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B and T cell immunity to HIV infection.

Do pluripotent stem cells exist in adult mice as very small embryonic stem cells?

Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development.