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Regenerative Medicine Program
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Selective vulnerability of motor neurons and dissociation of pre- and post-synaptic pathology at the neuromuscular junction in mouse models of spinal muscular atrophy.
Human molecular genetics Apr, 2008 | Pubmed ID: 18065780
Loss of translation elongation factor (eEF1A2) expression in vivo differentiates between Wallerian degeneration and dying-back neuronal pathology.
Journal of anatomy Dec, 2008 | Pubmed ID: 19094180
Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin.
Molecules and cells Mar, 2009 | Pubmed ID: 19326073
Pre-symptomatic development of lower motor neuron connectivity in a mouse model of severe spinal muscular atrophy.
Human molecular genetics Feb, 2010 | Pubmed ID: 19884170
Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy.
PLoS genetics Dec, 2009 | Pubmed ID: 20019802
Smoking cessation interventions in cancer care: opportunities for oncology nurses and nurse scientists.
Annual review of nursing research , 2009 | Pubmed ID: 20192107
SMN deficiency disrupts brain development in a mouse model of severe spinal muscular atrophy.
Human molecular genetics Nov, 2010 | Pubmed ID: 20705736
The response of neuromuscular junctions to injury is developmentally regulated.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2011 | Pubmed ID: 21228222
Induction of cell stress in neurons from transgenic mice expressing yellow fluorescent protein: implications for neurodegeneration research.
PloS one , 2011 | Pubmed ID: 21408118
Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.
Human molecular genetics Nov, 2011 | Pubmed ID: 21840928
A critical Smn threshold in mice dictates onset of an intermediate spinal muscular atrophy phenotype associated with a distinct neuromuscular junction pathology.
Neuromuscular disorders : NMD Nov, 2011 | Pubmed ID: 22071333
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.
BMC medicine , 2012 | Pubmed ID: 22397316
Defects in neuromuscular junction remodelling in the Smn(2B/-) mouse model of spinal muscular atrophy.
Neurobiology of disease Aug, 2012 | Pubmed ID: 22960106
A novel function for the survival motoneuron protein as a translational regulator.
Human molecular genetics Feb, 2013 | Pubmed ID: 23136128
Early onset muscle weakness and disruption of muscle proteins in mouse models of spinal muscular atrophy.
Skeletal muscle , 2013 | Pubmed ID: 24119341
Ottawa Hospital Research Institute
Lyndsay Murray1,
Thomas H Gillingwater2,
Rashmi Kothary1
1Regenerative Medicine Program, Ottawa Hospital Research Institute,
2Centre for Integrative Physiology, University of Edinburgh
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