Manuela Martins-Green

The cxc chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure.

The CXC chemokine cCAF stimulates precocious deposition of ECM molecules by wound fibroblasts, accelerating development of granulation tissue.

Combined administration of antibodies to human interleukin 8 and epidermal growth factor receptor results in increased antimetastatic effects on human breast carcinoma xenografts.

MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300.

Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells.

Histochemical localization of the PBAN receptor in the pheromone gland of Heliothis peltigera.

The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2.

Effects of "second-hand" smoke on structure and function of fibroblasts, cells that are critical for tissue repair and remodeling.

Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing.

Vascular endothelial growth factor activation of sterol regulatory element binding protein: a potential role in angiogenesis.

cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8).

A new generation organ culture arising from cross-talk between multiple primary human cell types.

A molecular mimic demonstrates that phosphorylated human prolactin is a potent anti-angiogenic hormone.

Activation of sterol regulatory element-binding proteins (SREBPs) is critical in IL-8-induced angiogenesis.

The effects of second-hand smoke on biological processes important in atherogenesis.

Cloning and characterization of the pheromone biosynthesis activating neuropeptide receptor gene in Spodoptera littoralis larvae.

Molecular mechanisms of thrombin-induced interleukin-8 (IL-8/CXCL8) expression in THP-1-derived and primary human macrophages.

A hCXCR1 transgenic mouse model containing a conditional color-switching system for imaging of hCXCL8/IL-8 functions in vivo.

Computational studies of CXCR1, the receptor of IL-8/CXCL8, using molecular dynamics and electrostatics.

Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability.

Origin of periendothelial cells in microvessels derived from human microvascular endothelial cells.

A one-plasmid conditional color-switching transgenic system for multimodal bioimaging.

An assay system for in vitro detection of permeability in human "endothelium".

Vascular endothelial growth factor promotes macrophage apoptosis through stimulation of tumor necrosis factor superfamily member 14 (TNFSF14/LIGHT).

Cell and molecular mechanisms of keratinocyte function stimulated by insulin during wound healing.

Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1.

Cell and molecular mechanisms of insulin-induced angiogenesis.

Second-hand cigarette smoke inhibits wound healing of the cornea by stimulating inflammation that delays corneal reepithelialization.

Reversal of second-hand cigarette smoke-induced impairment of corneal wound healing by thymosin beta4 combined with anti-inflammatory agents.

Systems biology applied to wound healing.

Sustained prolonged topical delivery of bioactive human insulin for potential treatment of cutaneous wounds.

Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda.

Alginate-PEG sponge architecture and role in the design of insulin release dressings.

Deletion of a tumor necrosis superfamily gene in mice leads to impaired healing that mimics chronic wounds in humans.

Microfabrication of cylindrical microfluidic channel networks for microvascular research.

Pomegranate juice and specific components inhibit cell and molecular processes critical for metastasis of breast cancer.

Specific pomegranate juice components as potential inhibitors of prostate cancer metastasis.

US-National Institutes of Health-funded research for cutaneous wounds in 2012.

Luteolin, ellagic acid and punicic acid are natural products that inhibit prostate cancer metastasis.

Pomegranate and its components as alternative treatment for prostate cancer.

Release of insulin from PLGA-alginate dressing stimulates regenerative healing of burn wounds in rats.

A membrane-activatable near-infrared fluorescent probe with ultra-photostability for mitochondrial membrane potentials.

Tobacco toxins deposited on surfaces (third hand smoke) impair wound healing.

Biomarkers of disease can be detected in mice as early as 4 weeks after initiation of exposure to third-hand smoke levels equivalent to those found in homes of smokers.

Insulin regulates multiple signaling pathways leading to monocyte/macrophage chemotaxis into the wound tissue.