Paul A. Slesinger

Evidence for a centrally located gate in the pore of a serotonin-gated ion channel.

betaL-betaM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(betagamma) subunit activation.

Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system.

Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.

Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex.

Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification.

Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells.

Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1.

Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins.

NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95.

Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.

Genetically encoding unnatural amino acids for cellular and neuronal studies.

The role of the cytoplasmic pore in inward rectification of Kir2.1 channels.

A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction.

RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.

Subunit-specific regulation of Kir3 channels by sorting nexin 27.

Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins.

Regulation of Kir2.1 channels by the Rho-GTPase, Rac1.

A discrete alcohol pocket involved in GIRK channel activation.

Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling.

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.

GABAB receptor coupling to G-proteins and ion channels.

Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses.

Probing novel GPCR interactions using a combination of FRET and TIRF.

Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.

Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27.

Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution.

Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses.