Paul C. Blainey

Single-molecule kinetics of lambda exonuclease reveal base dependence and dynamic disorder.

A base-excision DNA-repair protein finds intrahelical lesion bases by fast sliding in contact with DNA.

Multiplexed single-molecule assay for enzymatic activity on flow-stretched DNA.

Diffusion constant of a nonspecifically bound protein undergoing curvilinear motion along DNA.

Digital PCR provides sensitive and absolute calibration for high throughput sequencing.

Nonspecifically bound proteins spin while diffusing along DNA.

Digital MDA for enumeration of total nucleic acid contamination.

Genome of a low-salinity ammonia-oxidizing archaeon determined by single-cell and metagenomic analysis.

Partial genome assembly for a candidate division OP11 single cell from an anoxic spring (Zodletone Spring, Oklahoma).

Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).

Quantitative analysis of the human airway microbial ecology reveals a pervasive signature for cystic fibrosis.

A Single-cell genome for Thiovulum sp.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA AND to hexon of the precursor to protein VI, pVI, of human adenovirus.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction.

Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. viral proteinase slides along DNA to locate and process its substrates.

The future is now: single-cell genomics of bacteria and archaea.

Single-cell and metagenomic analyses indicate a fermentative and saccharolytic lifestyle for members of the OP9 lineage.

Optofluidic cell selection from complex microbial communities for single-genome analysis.

Dissecting genomic diversity, one cell at a time.

Laser microdissection of the alveolar duct enables single-cell genomic analysis.

Optimal estimation of diffusion coefficients from single-particle trajectories.

Tools for the Microbiome: Nano and Beyond.

A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages.

Molecular sled is an eleven-amino acid vehicle facilitating biochemical interactions via sliding components along DNA.

Molecular sled sequences are common in mammalian proteins.

Virtual microfluidics for digital quantification and single-cell sequencing.

Funding: Interdisciplinary challenges.

Sliding on DNA: From Peptides to Small Molecules.

High-throughput automated microfluidic sample preparation for accurate microbial genomics.

Microfluidic-based mini-metagenomics enables discovery of novel microbial lineages from complex environmental samples.