Roland Tisch

Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function.

L-selectin is not required for T cell-mediated autoimmune diabetes.

The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors.

NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages.

More stringent conditions of plasmid DNA vaccination are required to protect grafted versus endogenous islets in nonobese diabetic mice.

Critical roles of tumor necrosis factor-related apoptosis-inducing ligand in type 1 diabetes.

Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity.

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes.

Immunoregulation of dendritic cells.

Immunotherapy for the prevention and treatment of type 1 diabetes.

Low-avidity CD8lo T cells induced by incomplete antigen stimulation in vivo regulate naive higher avidity CD8hi T cell responses to the same antigen.

Early autoimmune destruction of islet grafts is associated with a restricted repertoire of IGRP-specific CD8+ T cells in diabetic nonobese diabetic mice.

Lymphopenia-driven CD8(+) T cells are resistant to antigen-induced tolerance in NOD.scid mice.

EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity.

Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells.

Identical beta cell-specific CD8(+) T cell clonotypes typically reside in both peripheral blood lymphocyte and pancreatic islets.

The type and frequency of immunoregulatory CD4+ T-cells govern the efficacy of antigen-specific immunotherapy in nonobese diabetic mice.

Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice.

Therapeutic B cell depletion impairs adaptive and autoreactive CD4+ T cell activation in mice.

MerTK is required for apoptotic cell-induced T cell tolerance.

B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions.

On the pathogenicity of autoantigen-specific T-cell receptors.

T-cell promiscuity in autoimmune diabetes.

Parameters influencing antigen-specific immunotherapy for type 1 diabetes.

ANCA patients have T cells responsive to complementary PR-3 antigen.

Gene gun-mediated DNA vaccination enhances antigen-specific immunotherapy at a late preclinical stage of type 1 diabetes in nonobese diabetic mice.

Immunotherapy of type 1 diabetes.

Parameters influencing antigen-specific immunotherapy for Type 1 diabetes.

Role of plasmacytoid dendritic cells in type 1 diabetes: friend or foe?

MerTK regulates thymic selection of autoreactive T cells.

Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo.

Cellular immune response to cryptic epitopes during therapeutic gene transfer.

CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice.

A novel role for c-Src and STAT3 in apoptotic cell-mediated MerTK-dependent immunoregulation of dendritic cells.

Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccination.

Islet lymphocyte subsets in male and female NOD mice are qualitatively similar but quantitatively distinct.

beta cell-specific CD4+ T cell clonotypes in peripheral blood and the pancreatic islets are distinct.

Toxin-coupled MHC class I tetramers can specifically ablate autoreactive CD8+ T cells and delay diabetes in nonobese diabetic mice.

Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells.

Immunogenic versus tolerogenic dendritic cells: a matter of maturation.

Adiponectin lowers glucose production by increasing SOGA.

Dysregulation of thymic clonal deletion and the escape of autoreactive T cells.

Genetic vaccination for re-establishing T-cell tolerance in type 1 diabetes.

Inducible adeno-associated virus-mediated IL-2 gene therapy prevents autoimmune diabetes.

Reduced IL-2 expression in NOD mice leads to a temporal increase in CD62Llo FoxP3+ CD4+ T cells with limited suppressor activity.

Cumulative autoimmunity: T cell clones recognizing several self-epitopes exhibit enhanced pathogenicity.

Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies.

IFN-γ receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells.

Autoreactive effector/memory CD4+ and CD8+ T cells infiltrating grafted and endogenous islets in diabetic NOD mice exhibit similar T cell receptor usage.

Kinetics of adeno-associated virus serotype 2 (AAV2) and AAV8 capsid antigen presentation in vivo are identical.

Manipulating T cell-mediated pathology: targets and functions of monoclonal antibody immunotherapy.

β-cell-specific IL-2 therapy increases islet Foxp3+Treg and suppresses type 1 diabetes in NOD mice.

Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner.

Cutting edge: Antigen-specific thymocyte feedback regulates homeostatic thymic conventional dendritic cell maturation.

IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells.

Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes.