Amplitude-Integrated EEG in Infants at Risk of Hypoxic-Ischemic Encephalopathy: A Feasibility Study in Road and Air Transport in Western Australia

We wanted to assess the feasibility of using an amplitude-integrated electroencephalogram during neonatal transport. Using clinical criteria, we determined whether the trace acquired during the transport was readable. This helps the clinician in the diagnosis and prognosis of babies requiring transportation following possible birth asphyxia or hypoxic ischemic encephalopathy.

Remote monitoring automated devices and innovative transport systems to improve outcomes in sick and premature newborns. Performing any research during transport has its difficulties but is essential in improving care. Getting appropriate consent is challenging in a time of acute stress.

The clinical team is required to perform research as well as clinical tasks, adding to the complexity of the transport process. We have established the necessity of undertaking research in neonatal transport and are seeking ways to improve the outcomes in babies who need to be transported after birth. We are working on means of improving thermal regulation in neonatal transport.

We would like to see whether amplitude-integrated EEG enables an earlier and more accurate diagnosis of hypoxic ischemic encephalopathy. We would also like to explore if machine learning can be used to augment diagnostic decisions. Finally, we wish to assess whether this has an impact on important outcomes such as mortality and neurodevelopmental outcomes.