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A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

DOI :

10.3791/60473-v

July 9th, 2020

July 9th, 2020

4,732 Views

1Department of Surgery, Division of Vascular Surgery, University of North Carolina at Chapel Hill, 2Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, 3Curriculum in Toxicology & Environmental Medicine, University of North Carolina at Chapel Hill, 4Department of Cell Biology & Physiology, University of North Carolina at Chapel Hill, 5McAllister Heart Institute, University of North Carolina at Chapel Hill

The rat carotid artery balloon injury mimics the clinical angioplasty procedure performed to restore blood flow in atherosclerotic vessels. This model induces the arterial injury response by distending the arterial wall, and denuding the intimal layer of endothelial cells, ultimately causing remodeling and an intimal hyperplastic response.

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Rat Carotid Artery

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