The authors acknowledge the facilities, and the scientific and technical assistance of the National Imaging Facility at the Centre for Advanced Imaging, University of Queensland. We would also like to thank Graham Galloway and Ian Brereton for their help to obtain a CAESIE grant for Thoralf Niendorf.

The study is approved by the ethics committee of the University of Queensland, Queensland, Australia and informed consent has been obtained from all subjects included in the study.
1. Subjects
<ol>
	<li>Recruit volunteer subjects over 18 years of age internally at the University of Queensland.</li>
	<li>Informed consent
	<ol>
		<li>Inform each subject about potential risks of undergoing the examination before entering the magnetic resonance imaging (MRI) safety zone. Specifically, discuss the ultra-high magnetic field exposure and possible contraindications for undergoing an MRI examination. Inform the subject that participating in the examination is voluntary and that at all times he/she may abort the examination. Obtain informed consent in writing.</li>
		<li>Explain the procedure to the participant. Since imaging is performed during breath hold at end expiration and consistent breath holding is integral to image quality, coach the subject on breathing technique prior to scanning.</li>
		<li>Perform MR safety screening on all subjects before entering the MRI safety zone in writing and again before entering the scanner room. Exclude subjects with contraindications for undergoing an MRI examination (e.g., pacemakers, implanted defibrillators, other unsafe medical implants or claustrophobia).</li>
	</ol>
	</li>
	<li>Ask the subject to change into scrubs before entering the scanner room.</li>
</ol>
2. Preparation
<ol>
	<li>Set up the additional hardware required to operate the dedicated 32 channel 1H cardiac transceiver (Tx/Rx) RF coil26 on the patient table as outlined in Figure 1a and b. Apart from a small power splitter box (Figure 1c), the auxiliary coil equipment comprises one power splitter box and phase shifter box (Figure 1d) and one Tx/Rx interface box (Figure 1e) for each of the two RF coil sections that will be placed below and on top of the subject. The greater part it accommodates the local transmit electronics, which is required for signal excitation at 7 Tesla, since traditional birdcage body coils as commonly employed at 1.5 T and 3.0 T are not available.</li>
	<li>Place the additional RF coil hardware at the top end of the patient table as outlined in Figure 1b and link the individual boxes together with the Bayonet Neill-Concelman (BNC) cables. Since the distance that the patient table can be driven into the MRI bore is limited, ensure to leave sufficient space on the patient table for the coil infrastructure to guarantee that the subject&#39;s heart can be positioned with the center of the coil at the isocenter of the magnet.</li>
	<li>Connect the Tx/Rx interface boxes to the four coil plugs on the patient table.</li>
	<li>Place the center of the posterior coil array 147 cm away from top end of the patient table (Figure 1b). This spot defines where the posterior coil array has to be placed to ensure that the subject&#39;s heart is at the isocenter of the magnet if the patient table is maximally driven into the bore. The placement on the predefined coil spot is crucial, to ensure optimal operation. Determine the optimal position of the posterior coil array as well as the positioning of the auxiliary equipment in preliminary tests including several volunteers of different body height.</li>
	<li>Connect the four cables of the posterior coil array into the appropriate sockets of the Tx/Rx interface box for the posterior array.</li>
	<li>Connect the four modules of the anterior coil array are with the Tx/Rx interface box for the top array and flip the array over the auxiliary coil equipment to allow for subject positioning.</li>
	<li>Attach the three ECG electrodes to the body of the subject. Follow the vendor guidelines for electrode placement to ensure optimal operation of the system&#39;s trigger algorithm.</li>
	<li>Position the subject on the patient table (Figure 1f). Critically, make sure that the subject&#39;s heart is positioned central to the posterior coil in order to guarantee scanning within the isocenter of the magnet. As, depending on the subject&#39;s height, the head will have to be placed on top of the coil/interface box connectors, place the cables carefully and use appropriate cushioning to ensure the subject&#39;s comfort and compliance.</li>
	<li>Connect the trigger device to the ECG electrodes.</li>
	<li>Attach the pulse trigger device to the subject&#39;s index finger. Use this second device for triggering in the event of severe distortions of the ECG signal introduced by the MHD effect.</li>
	<li>Hand the safety squeeze ball to the subjects.</li>
	<li>Equip the subject with headphones and earbuds to reduce the noise exposure and to allow communication with the subject.</li>
	<li>Place the anterior coil on the subject&#39;s chest, such that the cables that connect to the plugs E-F and G-H are located to the right and left of the subject&#39;s head, respectively.</li>
	<li>Drive the subject into the scanner bore. Perform the driving operation manually and ensure that the speed button of the table controls is in the off-position to guarantee the subject&#39;s safety during the driving process. Do not use the automatic mode as the variable table speed in this mode is optimized for neuro imaging and the distance the table can be driven automatically into the bore is limited by the scanner hardware.</li>
	<li>Check if communication to the subject through the intercom is possible and if the subject is feeling well.</li>
	<li>MR imaging
	<ol>
		<li>Run basic localizer (scout) scans along the three physical gradient axes for slice planning and B0-shimming.</li>
		<li>Use an ECG-triggered fast low angle shot (FLASH) sequence with the following acquisition parameters: field of view (FOV) = 400 mm, matrix = 192 x 144, slices per gradient axis = 1, thickness = 8 mm, echo time (TE) = 1.24, repetition time (TR) = 298 ms, flip angle = 10&#176;.</li>
		<li>Apply parallel MRI with acceleration factor = 2, reference lines = 24 and generalized autocalibrating partially parallel acquisitions (GRAPPA) reconstruction.</li>
		<li>Use the localizer images to verify that the subject&#39;s heart is positioned in the isocenter of the magnet. Reposition the subject if necessary.</li>
	</ol>
	</li>
	<li>3rd order B0-shimming
	<ol>
		<li>Open the 3rd order shim tool (Figure 2a) and reset all 3rd order shim currents (Figure 2b).</li>
		<li>Prescribe the shim volume for proper shimming over a region covering the heart (Figure 2c).</li>
		<li>Run a non-triggered advanced flow compensated 2D multi-echo FLASH shim sequence for the calculation of the 3rd order shim currents. Use the following parameters: FOV = 400 x 400 mm, matrix = 80 x 80, slices = 64, thickness = 5.0 mm, TE1 = 3.06, TE2 = 5.10, TR = 7 ms, flip angle = 20 &#176;, parallel MRI (GRAPPA), acceleration factor = 2, reference lines = 24.</li>
		<li>To calculate and apply the 3rd order shim currents, open the next protocol and copy the above-mentioned shim volume. Execute the SetShim program in the start menu (Figure 2a). Next, open the Manual Adjustments window in the Options menu (Figure 2d). In the 3D Shim tab, click Calculate | Apply to set the shim currents for the 2nd order (Figure 2e). Finally, set the shim currents by clicking Set Shim_3rd in the 3rd order shim tool (Figure 2b).</li>
		<li>Close the Manual Adjustments window. Keep the shim volume and the shim currents fixed throughout the remainder of the examination. Note that the shimming procedure can be highly system specific.</li>
	</ol>
	</li>
	<li>Acquire further localizers to support double-oblique slice planning. Unless stated otherwise, use a breath held and ECG-triggered 2D FLASH sequence with the following parameters for all localizer measurements: FOV = 360 x 290 mm, matrix = 256 x 206, thickness = 6.0 mm, TE = 1.57, TR = 3.9 ms, flip angle = 35 &#176;, parallel MRI (GRAPPA), acceleration factor: 2, reference lines: 24. Advise the patient to hold the breath in expiration. Employ high flip angles or use a segmented cine protocol (see below) to achieve improved contrast.
	<ol>
		<li>Acquire the 2 chamber localizer (1 slice), planned perpendicular on the axial scout parallel to the septal wall (Figure 3a).</li>
		<li>Acquire the 4 chamber localizer (1 slice), planned perpendicular on the 2 chamber localizer slice through the mitral valve and the apex of the left ventricle (Figure 3b).</li>
		<li>Acquire the short axis localizer (7 slices, FOV = 360 x 330 mm), planned perpendicular on the 4 chamber localizer parallel to the mitral valve and perpendicular to the septal wall (Figure 3c).</li>
	</ol>
	</li>
	<li>Perform the CINE acquisitions. Use a high resolution breath held ECG-triggered segmented 2D FLASH sequence with the following parameters: FOV = 360 x 270 mm, matrix = 256 x 192/264 x 352, thickness = 4.0 mm, TE = 3.14, TR = 6.3 ms, flip angle = 35-55 &#176;, segments = 7, parallel MRI (GRAPPA), acceleration factor = 2/3, temporal resolution = 42.6/44.3 ms.
	<ol>
		<li>Start with the left ventricular 4 chamber view (horizontal long axis, HLA) slices. Plan the central slice through the center of the mitral and tricuspid valves and the apex of the left ventricle (Figure 3d). Acquire each slice within an individual breath hold in expiration.</li>
		<li>Next, acquire the left ventricular short axis slices. Plan them perpendicular to the HLA and parallel to the mitral valve so that it covers the whole left ventricle from the base to the apex (Figure 3e). To ensure accurate function testing, position the first slice accurately at the mitral valve leaflet insertions, so that the center of the slice is within the ventricle. Again, acquire each slice within an individual breath hold in expiration.</li>
	</ol>
	</li>
</ol>

<ol>
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Kieran O'Brien and Jonathan Richer are employed by Siemens Ltd. Australia. Jan Rieger and Thoralf Niendorf are founders of MRI.TOOLS GmbH, Berlin, Germany. Jan Rieger was CTO and an employee of MRI.TOOLS GmbH. Thoralf Niendorf is CEO of MRI.TOOLS GmbH.

Functional CMR examinations could be conducted successfully at 7 Tesla. Based on the field strength driven SNR gain, CINE images of the human heart could be acquired with significantly higher spatial resolution compared to 1.5 or 3 T. While a slice thickness of 6 to 8 mm and in-plane voxel edge lengths of 1.2 to 2.0 mm are commonly used at lower clinical field strengths1,30, the measurements at 7 Tesla could be conducted with a slice thickness of 4 mm and an isot...

Cardiovascular magnetic resonance (CMR) is of proven clinical value with a growing range of clinical indications1,2. In particular, the evaluation of cardiac morphology and function is of major relevance and typically realized by tracking and visualizing the heart motion throughout the entire cardiac cycle using segmented breath-held two-dimensional (2D) cinematograpic (CINE) imaging techniques. While a high spatio-temporal resolution, high blood-myocardium contrast and high signal-to-noise ratio (SNR) are required, the data acquisition is highly constrained by the cardiac and respiratory motion and the use of multiple breath-holds as well as the need for whole heart or left-ventricular coverage often leads to extensive scan times. Parallel imaging, simultaneous multi-slice imaging or other acceleration techniques help to address the motion related constraints3,4,5,6.
Moreover, to benefit from the inherent SNR gain at higher magnetic fields, high field systems with B0 = 3 Tesla are increasingly employed in clinical routine7,8. The development has also encouraged investigations into ultra-high field (B0&#8805;7 Tesla, f&#8805;298 MHz) CMR9,10,11,12,13,14. The gain in SNR and blood-myocardium contrast inherent to the higher field strength holds the promise to be transferrable into enhanced functional CMR using a spatial resolution that exceeds today&#39;s limits15,16,17. In turn, new possibilities for magnetic resonance (MR) based myocardial tissue characterization, metabolic imaging and microstructure imaging are expected13. So far, several groups have demonstrated the feasibility of CMR at 7 Tesla and specifically tailored ultra-high field technology has been introduced17,18,19,20,21,22. Regarding these promising developments, the potential of ultra-high field CMR can be considered to be yet untapped13. At the same time, physical phenomena and practical obstacles such as magnetic field inhomogeneities, radio frequency (RF) excitation field non-uniformities, off-resonance artifacts, dielectric effects, localized tissue heating and field strength independent RF power deposition constraints make imaging at ultra-high field challenging10,17. The latter are employed to control RF induced tissue heating and to ensure safe operation. Moreover, electrocardiogram (ECG) based triggering can be significantly impacted by the magneto-hydrodynamic (MHD) effect19,23,24. To address the challenges induced by the short wavelength in tissue, many-element transceiver RF coil arrays tailored for CMR at 7 Tesla were proposed21,25,26,27. Parallel RF transmission provides means for transmission field shaping, also known as B1+ shimming, which allows to reduce the magnetic field inhomogeneities and susceptibility artefacts18,28. While at the current stage, some of these measures might increase the experimental complexity, the concepts have proven helpful and may be translated to the clinical field strengths of CMR 1.5 T or 3 T.
Currently, 2D balanced steady state free precession (bSSFP) CINE imaging is the standard of reference for clinical functional CMR at 1.5 T and 3 T1. Recently, the sequence was successfully employed at 7 Tesla, but a large number of challenges remain19. Patient specific B1+ shimming and extra RF coil adjustments were applied to manage RF power deposition constraints and careful B0 shimming was performed to control the sequence typical banding artifacts. With an average scan time of 93 minutes for left-ventricular (LV) function assessment, the efforts prolonged the examination times beyond clinically acceptable limits. Here, spoiled gradient echo sequences provide a viable alternative. At 7 Tesla, total examination times of (29 &#177; 5) min for LV function assessment were reported, which corresponds well to clinical imaging protocols at lower field strengths21. Thereby, spoiled gradient echo based CMR benefits from the prolonged T1 relaxation times at ultra-high field that result in an enhanced blood-myocardium contrast superior to gradient echo imaging at 1.5 T. This renders subtle anatomic structures such as the pericardium, the mitral and tricuspid valves as well as the papillary muscles well identifiable. Congruously, spoiled gradient echo based cardiac chamber quantification at 7 Tesla agrees closely with LV parameters derived from 2D bSSFP CINE imaging at 1.5 T20. Apart from that, accurate right-ventricular (RV) chamber quantification was recently demonstrated feasible using a high resolution spoiled gradient echo sequence at 7 Tesla29.
Recognizing the challenges and opportunities of CMR at ultra-high field, this work presents a setup and protocol customized for functional CMR acquisitions on an investigational 7 Tesla research scanner. The protocol outlines the technical underpinnings, shows how impediments can be overcome, and provides practical considerations that help to keep the extra experimental overhead at a minimum. The proposed imaging protocol constitutes a four-fold improvement in the spatial resolution versus today&#39;s clinical practice. It is meant to provide a guideline for clinical adaptors, physician scientists, translational researchers, application experts, MR radiographers, technologists and new entrants into the field.

<table border="0" cellpadding="0" cellspacing="0" style="width:572px;" width="573">
	<tbody>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">7 Tesla MRI system</td>
			<td style="width:71px;">Siemens</td>
			<td style="width:119px;"></td>
			<td style="width:167px;">Investigational Device</td>
		</tr>
		<tr height="42">
			<td height="42" style="height:42px;width:216px;">32-Channel -1H-Cardiac Coil</td>
			<td style="width:71px;">MRI.Tools GmbH</td>
			<td style="width:119px;"></td>
			<td>Transmit/Receive RF Coil for MR Imaging and Spectroscopy at 7.0 Tesla</td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">ECG Trigger Device</td>
			<td style="width:71px;">Siemens</td>
			<td style="width:119px;"></td>
			<td></td>
		</tr>
		<tr height="21">
			<td height="21" style="height:21px;width:216px;">Pulse Trigger Device</td>
			<td style="width:71px;">Siemens</td>
			<td style="width:119px;"></td>
			<td></td>
		</tr>
	</tbody>
</table>

cardiac magnetic resonance imaging at 7 tesla

CMR at an ultra-high field (magnetic field strength B0&#160;&#8805; 7 Tesla) benefits from the signal-to-noise ratio (SNR) advantage inherent at higher magnetic field strengths and potentially provides improved signal contrast and spatial resolution. While promising results have been achieved, ultra-high field CMR is challenging due to energy deposition constraints and physical phenomena such as transmission field non-uniformities and magnetic field inhomogeneities. In addition, the magneto-hydrodynamic effect renders the synchronization of the data acquisition with the cardiac motion difficult. The challenges are currently addressed by explorations into novel magnetic resonance technology. If all impediments can be overcome, ultra-high field CMR may generate new opportunities for functional CMR, myocardial tissue characterization, microstructure imaging or metabolic imaging. Recognizing this potential, we show that multi-channel radio frequency (RF) coil technology tailored for CMR at 7 Tesla together with higher order B0 shimming and a backup signal for cardiac triggering facilitates high fidelity functional CMR. With the proposed setup, cardiac chamber quantification can be accomplished in examination times similar to those achieved at lower field strengths. To share this experience and to support the dissemination of this expertise, this work describes our setup and protocol tailored for functional CMR at 7 Tesla.

Representative results of cardiac CINE examinations derived from volunteers are depicted in Figure 4. Shown are diastolic and systolic time-frames of short axis and a four-chamber long axis views of the human heart. The significantly higher spatial resolution for the short axis views (Figure&#160;4a, 4b, 4e, 4f) compared to the long axis views (Figure&#160;4c...

Watch this Scientific Journal Video about Cardiac Magnetic Resonance Imaging at 7 Tesla at JoVE.com

Cardiac Magnetic Resonance Imaging at 7 Tesla

The sensitivity gain inherent to ultrahigh field magnetic resonance holds promise for high spatial resolution imaging of the heart. Here, we describe a protocol customized for functional cardiovascular magnetic resonance (CMR) at 7 Tesla using an advanced multi-channel radio-frequency coil, magnetic field shimming and a triggering concept.

CMR at an ultra-high field (magnetic field strength B0&#160;&#8805; 7 Tesla) benefits from the signal-to-noise ratio (SNR) advantage inherent at higher ...

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11.0K Views.  The University of Queensland, Brisbane, Australia. The sensitivity gain inherent to ultrahigh field magnetic resonance holds promise for high spatial resolution imaging of the heart. Here, we describe a protocol customized for functional cardiovascular magnetic resonance (CMR) at 7 Tesla using an advanced multi-channel radio-frequency coil, magnetic field shimming and a triggering concept. 