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university of Tabriz

3 ARTICLES PUBLISHED IN JoVE

Neuroscience

A Protocol for Transcranial Photobiomodulation Therapy in Mice

Farzad Salehpour^1,2, Luis De Taboada³, Paolo Cassano^4,5,6, Farzin Kamari¹, Javad Mahmoudi¹, Sohrab Ahmadi-Kandjani⁷, Seyed Hossein Rasta^8,9,10, Saeed Sadigh-Eteghad¹

¹Neurosciences Research Center, Tabriz University of Medical Sciences, ²ProNeuroLIGHT LLC, ³LiteCure LLC, ⁴Department of Psychiatry, Harvard Medical School, ⁵Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, ⁶Center for Anxiety and Traumatic Stress Disorders, Department of Psychiatry, Massachusetts General Hospital, ⁷Research Institute for Applied Physics and Astronomy, University of Tabriz, ⁸Department of Medical Physics, Tabriz University of Medical Sciences, ⁹Department of Medical Bioengineering, Tabriz University of Medical Sciences, ¹⁰School of Medical Sciences, University of Aberdeen

Photobiomodulation therapy is an innovative noninvasive modality for the treatment of a wide range of neurological and psychiatric disorders and can also improve healthy brain function. This protocol includes a step-by-step guide to performing brain photobiomodulation in mice by transcranial light delivery, which can be adapted for use in other laboratory rodents.

Behavior

Back Mechanical Sensitivity Assessment in the Rat for Mechanistic Investigation of Chronic Back Pain

Hatef Khosravi^1,2, Nasim Eskandari^1,2, Benjamin Provencher^1,2, Thierry Paquette^1,2, Hugues Leblond^1,2, Emad Khalilzadeh^1,3, Mathieu Piché^1,2

¹Department of Anatomy, Université du Québec à Trois-Rivières, ²CogNAC Research Group, Université du Québec à Trois-Rivières, ³Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz

To develop novel therapeutic interventions for the prevention and management of back pain, animal models are required to examine the mechanisms and effectiveness of these therapies from a translational perspective. The present protocol describes the BMS test, a standardized method to assess back mechanical sensitivity in the rat.

JoVE Core

Microfluidic Device for the Separation of Non-Metastatic (MCF-7) and Non-Tumor (MCF-10A) Breast Cancer Cells Using AC Dielectrophoresis

Ateeq ur Rehman¹, Rahman S. Zabibah², Samira Kharratian³, Adil Mustafa^4,5

¹Department of Biomedical Engineering, Foundation University Islamabad, ²College of Medical Technology, The Islamic University Najaf, ³Faculty of Mechanical Engineering, University of Tabriz, ⁴Department of Engineering Mathematics, University of Bristol, ⁵School of Life Sciences, University of Warwick

Breast cancer cells exhibit different dielectric properties compared to non-tumor breast epithelial cells. It has been hypothesized that, based on this difference in dielectric properties, the two populations can be separated for immunotherapy purposes. To support this, we model a microfluidic device to sort MCF-7 and MCF-10A cells.