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Yerevan State Medical University

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Rat Model of Adhesive Capsulitis of the Shoulder

Stephen M. Okajima^*1, M. Belen Cubria^*1, Sharri J. Mortensen¹, Juan C. Villa-Camacho¹, Philip Hanna¹, Aron Lechtig¹, Miguel Perez-Viloria¹, Patrick Williamson¹, Mark W. Grinstaff^*3, Edward K. Rodriguez^*2, Ara Nazarian^*1,4

¹Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, ²Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, ³Departments of Biomedical Engineering, Chemistry, and Medicine, Boston University, ⁴Department of Orthopaedic Surgery, Yerevan State Medical University

This protocol presents an in vivo rat model of adhesive capsulitis. The model includes an internal fixation of the glenohumeral joint with extra-articular suture fixation for an extended time, resulting in a decreased rotational range of motion (ROM) and increased joint stiffness.

Bioengineering

A Passive Ankle Dorsiflexion Testing System for an In Vivo Model of Overuse-induced Tendinopathy

Pooja H. Chainani^1,2, Patrick M. Williamson^1,2, Diana Yeritsyan¹, Kaveh Momenzadeh¹, Nadim Kheir¹, Joseph P. DeAngelis^1,3, Arun J. Ramappa^1,3, Ara Nazarian^1,2,3,4

¹Musculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, ²Mechanical Engineering Department, Boston University, ³Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, ⁴Department of Orthopaedic Surgery, Yerevan State Medical University

This protocol presents a testing system used to induce quantifiable and controlled fatigue injuries in a rat Achilles tendon for an in-vivo model of overuse-induced tendinopathy. The procedure consists of securing the rat's ankle to a joint actuator that performs passive ankle dorsiflexion with a custom-written MATLAB script.