GE Global Research
2 ARTICLES PUBLISHED IN JoVE
Cancer Research
Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
Eugen Kubala *1,2,3, Kim A. Muñoz-Álvarez *1, Geoffrey Topping 1, Christian Hundshammer 1,2, Benedikt Feuerecker 1, Pedro A. Gómez 3,4, Giorgio Pariani 1,5,6, Franz Schilling 1, Steffen J. Glaser 2, Rolf F. Schulte 3, Marion I. Menzel 3, Markus Schwaiger 1
1Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, 2Department of Chemistry, Technische Universität München, 3GE Global Research, 4Zentralinstitut für Medizintechnik der Technischen Universität München (IMETUM), Technische Universität München, 5Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, 6IDG Institute of Developmental Genetics, Helmholtz Zentrum München
Dynamic nuclear polarization with subsequent sample dissolution has enabled real-time studies of metabolism in biological systems. Hyperpolarized [1-13C]pyruvate was used to study lactate dehydrogenase activity in a prostate carcinoma cell line in vitro.
Bioengineering
Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
Flemming Forsberg 1, Ipshita Gupta 1,2, Priscilla Machado 1, Colette M. Shaw 1, Jonathan M. Fenkel 3, Kirk Wallace 4, John R. Eisenbrey 1
1Department of Radiology, Thomas Jefferson University, 2School of Biomedical Engineering, Sciences and Health Systems, Drexel University, 3Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, 4GE Global Research
A protocol for noninvasively estimating ambient pressures utilizing subharmonic ultrasound imaging of infused contrast microbubbles (following appropriate calibration) is described with examples from human patients with chronic liver disease.
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