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GE Global Research

2 ARTICLES PUBLISHED IN JoVE

Cancer Research

Hyperpolarized ¹³C Metabolic Magnetic Resonance Spectroscopy and Imaging

Eugen Kubala^*1,2,3, Kim A. Muñoz-Álvarez^*1, Geoffrey Topping¹, Christian Hundshammer^1,2, Benedikt Feuerecker¹, Pedro A. Gómez^3,4, Giorgio Pariani^1,5,6, Franz Schilling¹, Steffen J. Glaser², Rolf F. Schulte³, Marion I. Menzel³, Markus Schwaiger¹

¹Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, ²Department of Chemistry, Technische Universität München, ³GE Global Research, ⁴Zentralinstitut für Medizintechnik der Technischen Universität München (IMETUM), Technische Universität München, ⁵Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München, ⁶IDG Institute of Developmental Genetics, Helmholtz Zentrum München

Dynamic nuclear polarization with subsequent sample dissolution has enabled real-time studies of metabolism in biological systems. Hyperpolarized [1-¹³C]pyruvate was used to study lactate dehydrogenase activity in a prostate carcinoma cell line in vitro.

Bioengineering

Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension

Flemming Forsberg¹, Ipshita Gupta^1,2, Priscilla Machado¹, Colette M. Shaw¹, Jonathan M. Fenkel³, Kirk Wallace⁴, John R. Eisenbrey¹

¹Department of Radiology, Thomas Jefferson University, ²School of Biomedical Engineering, Sciences and Health Systems, Drexel University, ³Department of Medicine, Division of Gastroenterology and Hepatology, Thomas Jefferson University, ⁴GE Global Research

A protocol for noninvasively estimating ambient pressures utilizing subharmonic ultrasound imaging of infused contrast microbubbles (following appropriate calibration) is described with examples from human patients with chronic liver disease.