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St. Vincent's Hospital Melbourne

2 ARTICLES PUBLISHED IN JoVE

Medicine

Assessment of the Anticoagulant and Anti-inflammatory Properties of Endothelial Cells Using 3D Cell Culture and Non-anticoagulated Whole Blood

Riccardo Sfriso^1,2, Anjan Bongoni³, Yara Banz⁴, Nikolai Klymiuk⁵, Eckhard Wolf⁵, Robert Rieben¹

¹Department of Clinical Research, University of Bern, ²Graduate School for Cellular and Biomedical Sciences, University of Bern, ³Immunology Research Centre, St. Vincent's Hospital Melbourne, ⁴Institute of Pathology, University of Bern, ⁵Institute of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian University

We present an in vitro model which allows the study and analysis of coagulation in whole, non-anticoagulated blood. Anticoagulation in the system depends on the natural anticoagulation effect of healthy endothelial cells and endothelial cell activation will result in clotting.

Education

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Andria Pelentritou¹, Levin Kuhlmann¹, John Cormack², Will Woods³, Jamie Sleigh⁴, David Liley¹

¹Centre for Human Psychopharmacology, Swinburne University of Technology, ²Department of Anaesthesia and Pain Management, St. Vincent's Hospital Melbourne, ³Brain and Psychological Science Research Centre, Swinburne University of Technology, ⁴Department of Anaesthesiology, University of Auckland

Simultaneous magnetoencephalography and electroencephalography provides a useful tool to search for common and distinct macro-scale mechanisms of reductions in consciousness induced by different anesthetics. This paper illustrates the empirical methods underlying the recording of such data from healthy humans during N-Methyl-D-Aspartate-(NMDA)-receptor-antagonist-based anesthesia during inhalation of nitrous oxide and xenon.