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London Health Science Centre

2 ARTICLES PUBLISHED IN JoVE

Medicine

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Choi-Fong Cho¹, Amber Ablack², Hon-Sing Leong², Andries Zijlstra³, John Lewis^2,4

¹Department of Medical Biophysics, University of Western Ontario, ²London Regional Cancer Program, London Health Science Centre, ³Department of Pathology, Vanderbilt University , ⁴Translational Prostate Cancer Research Group, London Health Science Centre

We present a novel approach to quantify nanoparticle localization in the vasculature of human xenografted tumors using dynamic, real-time intravital imaging in an avian embryo model.

JoVE Journal

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model

Trenis D. Palmer¹, John Lewis², Andries Zijlstra¹

¹Department of Pathology, Vanderbilt University , ²Departments of Oncology, Surgery and Medical Biophysics, London Regional cancer program

Using quantitative PCR, we demonstrate how the well-established chick CAM model can be used to quantitatively analyze the metastasis of human tumor cells to distant organs.