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Clement J. Zablocki Veterans Affairs Medical Center

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Dorothee Weihrauch¹, John G. Krolikowski^1,2, Deron W. Jones³, Tahniyath Zaman³, Omoshalewa Bamkole¹, Janine Struve⁴, Paul S. Pagel⁵, Nicole L. Lohr⁶, Kirkwood A. Pritchard, Jr.³

¹Department of Anesthesiology, Medical College of Wisconsin, ²Clement J. Zablocki Veterans Affairs Medical Center, ³Department of Surgery, Division of Pediatric Surgery, Children's Research Institute, ⁴Department of Orthopedic Surgery, Medical College of Wisconsin, ⁵Deptarment of Anesthesiology, Clement J Zblocki Veteran Affairs Medical Center, ⁶Department of Medicine, Division of Cardiology, Medical College of Wisconsin

We describe the isolation of cardiac extracellular matrix from C57Bl/6J control mice, tight-skin mice, and tight-skin mice treated with the IRF5 inhibitory peptide. We also describe the vasodilation studies on the isolated vessels from C57Bl/6J, tight-skin mice and tight-skin mice treated with the IRF5 inhibitory peptide.

Medicine

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery

Paul S. Pagel¹, Lonnie Dye III², Graham E.D. Hill², Juan L. Vega², Justin N. Tawil², Derek J. De Vry², Kiran Chandrashekarappa¹, Zafar Iqbal¹, Brent T. Boettcher¹, Julie K. Freed²

¹Anesthesia Service, Clement J. Zablocki Veterans Affairs Medical Center, ²Department of Anesthesiology, Medical College of Wisconsin

We describe a protocol to measure vortex formation time, an index of left ventricular filling efficiency, using standard transesophageal echocardiography techniques in patients undergoing cardiac surgery. We apply this technique to analyze vortex formation time in several groups of patients with differing cardiac pathologies.