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Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus

2 ARTICLES PUBLISHED IN JoVE

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Medicine

A Rat Tibial Growth Plate Injury Model to Characterize Repair Mechanisms and Evaluate Growth Plate Regeneration Strategies
Christopher B. Erickson 1, Nichole Shaw 2, Nancy Hadley-Miller 2, Michael S. Riederer 3, Melissa D. Krebs 3, Karin A. Payne 4
1Department of Bioengineering, Department of Orthopedics, University of Colorado Anschutz Medical Campus, 2Department of Orthopedics, University of Colorado Anschutz Medical Campus, 3Department of Chemical & Biological Engineering, Colorado School of Mines, 4Department of Orthopedics, Gates Center for Regenerative Medicine, University of Colorado Anschutz Medical Campus

The growth plate is a cartilaginous region in children's long bones where longitudinal growth occurs. When injured, bony tissue can form and impair growth. We describe a rat model of growth plate injury that leads to bony repair tissue, allowing the study of repair mechanisms and growth plate regeneration strategies.

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Bioengineering

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
Michael A. Stager 1, Christopher B. Erickson 2, Karin A. Payne 2, Melissa D. Krebs 1
1Department of Chemical and Biological Engineering, Colorado School of Mines, 2Department of Orthopedics, University of Colorado Anschutz Medical Campus

The present protocol describes a non-emulsion-based method for the fabrication of chitosan-genipin microgels. The size of these microgels can be precisely controlled, and they can display pH-dependent swelling, degrade in vivo, and be loaded with therapeutic molecules that release over time in a sustained manner, making them highly relevant for tissue engineering applications.

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