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Austrian Competence Center for Feed and Food Quality, Safety and Innovation

2 ARTICLES PUBLISHED IN JoVE

Biology

In-vivo Detection of Protein-protein Interactions on Micro-patterned Surfaces

Julian Weghuber¹, Stefan Sunzenauer¹, Mario Brameshuber¹, Birgit Plochberger¹, Clemens Hesch¹, Gerhard J. Schutz¹

¹Institute of Biophysics, Johannes Kepler Universitat Linz

This video shows experiments with subsequent analysis of protein-protein interactions by the use of micro-patterned surfaces. The approach offers the possibility to detect protein interactions in living cells and combines high throughput capabilities with the possibility to extract quantitative information.

JoVE Core

An In Ovo Model for Testing Insulin-mimetic Compounds

Renate Haselgrübler^*1, Flora Stübl^*1, Verena Stadlbauer^1,2, Peter Lanzerstorfer¹, Julian Weghuber^1,2

¹University of Applied Sciences Upper Austria, ²Austrian Competence Center for Feed and Food Quality, Safety and Innovation

In this study, we describe an in-ovo system as a promising tool to test insulin-mimetic compounds in a living organism. The main advantages include adequate throughput rates and acceptable costs, which enable the identification of phytochemicals with insulin-mimetic properties.