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Instituto de Investigaciones Biomédicas, CSIC-UAM

1 ARTICLES PUBLISHED IN JoVE

Cancer Research

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Julia Ramirez-Moya^1,2, León Wert-Lamas¹, Adrián Acuña-Ruiz^1,2, Miguel A. Zaballos^1,2, Pilar Santisteban^1,2

¹Instituto de Investigaciones Biomédicas, CSIC-UAM, ²Ciberonc, Instituto de Salud Carlos III

This protocol describes xenograft and orthotopic mouse models of human thyroid tumorigenesis as a platform to test microRNA-based inhibitor treatments. This approach is ideal to study the function of non-coding RNAs and their potential as new therapeutic targets.