In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in MiceJulia Ramirez-Moya 1,2, León Wert-Lamas 1, Adrián Acuña-Ruiz 1,2, Miguel A. Zaballos 1,2, Pilar Santisteban 1,2
1Instituto de Investigaciones Biomédicas, CSIC-UAM, 2Ciberonc, Instituto de Salud Carlos III
This protocol describes xenograft and orthotopic mouse models of human thyroid tumorigenesis as a platform to test microRNA-based inhibitor treatments. This approach is ideal to study the function of non-coding RNAs and their potential as new therapeutic targets.