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Hospital Universitario Virgen del Rocío/Universidad de Sevilla

1 ARTICLES PUBLISHED IN JoVE

JoVE Core

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Mi-Kyung Shin¹, Lenise J. Kim¹, Candela Caballero-Eraso², Vsevolod Y. Polotsky¹

¹Department of Medicine, Johns Hopkins University, ²Instituto de Biomedicina de Sevilla (IBiS), Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Hospital Universitario Virgen del Rocío/Universidad de Sevilla

Our study focuses on the effects of leptin signaling in carotid body (CB) on the hypoxic ventilatory response (HVR). We performed 'loss of function' experiments measuring the effect of leptin on HVR after CB denervation and 'gain of function' experiments measuring HVR after overexpression of the leptin receptor in CB.