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Veterans Affairs Puget Sound Health Care System

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Evaluation of Motor Impairment in C. elegans Models of Amyotrophic Lateral Sclerosis

Heather N. Currey¹, Nicole F. Liachko^1,2

¹Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, ²Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington

This protocol describes two sensitive assays for discriminating among mild, moderate, and severe motor impairment in C. elegans models of amyotrophic lateral sclerosis, with general utility for C. elegans strains, with altered motility.