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Jawaharlal Nehru University

2 ARTICLES PUBLISHED IN JoVE

¹School of Life Sciences, Jawaharlal Nehru University

DNA and Chromatin Mechanics

Biology

Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases

Himashree Choudhury^*1, Manish Sharma^*1, Utkarsh Gangwar¹, Nayla Siddiqui¹, Abhisheka Bansal^1,2

¹Cellular and Molecular Parasitology Laboratory, School of Life Sciences, Jawaharlal Nehru University, ²Laboratory of Malaria and Vector Research and National Institutes of Allergy and Infectious Diseases, National Institutes of Health

Chemical genetics involves the substitution of a gatekeeper residue with an amino acid containing a different side chain at the target locus. Here, we have generated a mutant parasite containing a hypomorphic allele of cdpk1 and identified compensatory pathways adopted by the parasite in the mutant background.