Jawaharlal Nehru University
2 ARTICLES PUBLISHED IN JoVE
DNA and Chromatin Mechanics
Rohini Muthuswami 1
1School of Life Sciences, Jawaharlal Nehru University
DNA and Chromatin Mechanics
Biology
Understanding the Development of Compensatory Pathways in a Mutant Malaria Parasite Harbouring Hypomorphic Allele of Plant-Like Kinases
Himashree Choudhury *1, Manish Sharma *1, Utkarsh Gangwar 1, Nayla Siddiqui 1, Abhisheka Bansal 1,2
1Cellular and Molecular Parasitology Laboratory, School of Life Sciences, Jawaharlal Nehru University, 2Laboratory of Malaria and Vector Research and National Institutes of Allergy and Infectious Diseases, National Institutes of Health
Chemical genetics involves the substitution of a gatekeeper residue with an amino acid containing a different side chain at the target locus. Here, we have generated a mutant parasite containing a hypomorphic allele of cdpk1 and identified compensatory pathways adopted by the parasite in the mutant background.
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