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Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine

2 ARTICLES PUBLISHED IN JoVE

Medicine

Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

Xu-yi Zhao¹, Yun-yue Yang¹, Jing-li Feng¹, Cui-ling Feng²

¹Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, ²Traditional Chinese Medicine Department, Peking University People's Hospital

This study reveals the mechanism of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma based on network pharmacology and experimental verification. The study also demonstrates that the PI3K/AKT signaling pathway plays a vital role in the action of Trichosanthes-Fritillaria thunbergii in treating lung adenocarcinoma.

Medicine

Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway

Jingyu Mao^*1, Qin Lu^*2, Fei Gao³, Hao Liu⁴, Jinchuan Tan⁵

¹Graduate School, Hebei University of Chinese Medicine, ²School of Basic Medical Sciences, Hebei University of Chinese Medicine, ³Department of Endocrinology and Nephrology, Renal Research Institute of Beijing University of Chinese Medicine, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, ⁴Hebei Province Academy of Chinese Medicine Sciences, ⁵Department of Nephrology, First Affiliated Hospital, Hebei University of Chinese Medicine

Here, we present a protocol describing network pharmacology and molecular docking techniques to explore the mechanism of action of Jiawei Shengjiang San (JWSJS) in treating diabetic nephropathy.