Results: Drug Delivery by Canalostomy Resulted in Widespread Distribution of the Reagent Throughout the Cochlea and Vestibular End-organs
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Conclusion
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The overall goal of this study is to describe the surgical techniques involved in a canalostomy in both adult and neonatal mice. This method first in the late 80s. Broad distribution of injected reagents in the cochlear and vestibular end organs o
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Here we describe canalostomy procedure which allows local drug delivery into the inner ears of adult and neonatal mice through the semicircular canal with minimum damage to hearing and vestibular function. This method can be used to inoculate viral vectors, pharmaceuticals, and small molecules into the mouse inner ear.