Our research aims to uncover how chromatin organization controls gene expression. The focus is on determining what factors regulate chromatin at the gene level to control gene activity. Currently, technologies similar to chromosome confirmation capture, or 3C, are used to make progress in this field.
Investments in sample collection and sequencing technologies have pushed us what the 3C techniques can show us. The greatest experimental challenge currently is collecting samples having uniform chromatin architecture. Heterogeneity in samples leads to confounding results.
In the future, we'll be focusing on how changes in chromatin organization play a role in cancer.
