Marcel Hollenstein

Synthesis and incorporation into PNA of fluorinated olefinic PNA (F-OPA) monomers.

Fluorinated peptide nucleic acid.

Fluorinated olefinic peptide nucleic acid: synthesis and pairing properties with complementary DNA.

A highly selective DNAzyme sensor for mercuric ions.

In vitro selection of a DNAzyme with three modified nucleotides.

A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M2+).

A DNAzyme with three protein-like functional groups: enhancing catalytic efficiency of M2+-independent RNA cleavage.

Protein-inspired modified DNAzymes: dramatic effects of shortening side-chain length of 8-imidazolyl modified deoxyadenosines in selecting RNaseA mimicking DNAzymes.

A divalent metal-dependent self-cleaving DNAzyme with a tyrosine side chain.

Expanding the catalytic repertoire of DNAzymes by modified nucleosides.

Polymerase incorporation of pyrene-nucleoside triphosphates.

Synthesis of deoxynucleoside triphosphates that include proline, urea, or sulfonamide groups and their polymerase incorporation into DNA.

Nucleoside triphosphates--building blocks for the modification of nucleic acids.

Toward the combinatorial selection of chemically modified DNAzyme RNase A mimics active against all-RNA substrates.

Deoxynucleoside triphosphates bearing histamine, carboxylic acid, and hydroxyl residues--synthesis and biochemical characterization.