Valentina Gandin

Chemistry and biological activity of platinum amidine complexes.

Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways.

GABP complex regulates transcription of eIF6 (p27BBP), an essential trans-acting factor in ribosome biogenesis.

Synthesis, characterization, and in vitro antitumor properties of tris(hydroxymethyl)phosphine copper(I) complexes containing the new bis(1,2,4-triazol-1-yl)acetate ligand.

Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.

Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy.

In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand.

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.

Effects of the antioxidant Pycnogenol on cellular redox systems in U1285 human lung carcinoma cells.

DNA binding ellipticine analogues: synthesis, biological evaluation, and structure-activity relationships.

Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift.

Cytotoxicity of cis-platinum(II) cycloaliphatic amidine complexes: Ring size and solvent effects on the biological activity.

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase.

Synthesis and structural characterization of copper(I) complexes bearing N-methyl-1,3,5-triaza-7-phosphaadamantane (mPTA): cytotoxic activity evaluation of a series of water soluble Cu(I) derivatives containing PTA, PTAH and mPTA ligands.

Synthesis, characterization, and cytotoxicity of dinuclear platinum-bisphosphonate complexes to be used as prodrugs in the local treatment of bone tumours.

JNK inhibition arrests cotranslational degradation.

The relationship between the electrospray ionization behaviour and biological activity of some phosphino Cu(I) complexes.

S6K1 plays a critical role in early adipocyte differentiation.

Cytotoxicity in human cancer cells and mitochondrial dysfunction induced by a series of new copper(I) complexes containing tris(2-cyanoethyl)phosphines.

A new class of antitumor trans-amine-amidine-Pt(II) cationic complexes: influence of chemical structure and solvent on in vitro and in vivo tumor cell proliferation.

In vitro antitumour activity of water soluble Cu(I), Ag(I) and Au(I) complexes supported by hydrophilic alkyl phosphine ligands.

A novel copper complex induces paraptosis in colon cancer cells via the activation of ER stress signalling.

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications.

Psoralenquinones as a novel class of proteasome inhibitors: design, synthesis and biological evaluation.

Synthesis, characterization and cytotoxic properties of platinum(II) complexes containing the nucleosides adenosine and cytidine.

Nitroimidazole and glucosamine conjugated heteroscorpionate ligands and related copper(II) complexes. Syntheses, biological activity and XAS studies.

Photoreactivity of 5-fluorouracil under UVB light: photolysis and cytotoxicity studies.

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression.

Nanocrystalline carbonate-apatites: role of Ca/P ratio on the upload and release of anticancer platinum bisphosphonates.

Synthesis and characterization of azolate gold(I) phosphane complexes as thioredoxin reductase inhibiting antitumor agents.

Revisiting [PtCl₂(cis-1,4-DACH)]: an underestimated antitumor drug with potential application to the treatment of oxaliplatin-refractory colorectal cancer.

Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila.

Synthesis and biological activity of ester- and amide-functionalized imidazolium salts and related water-soluble coinage metal N-heterocyclic carbene complexes.

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies.

Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems.

Neutral and charged phosphine/scorpionate copper(I) complexes: effects of ligand assembly on their antiproliferative activity.

(99m)Tc(N)-DBODC(5), a potential radiolabeled probe for SPECT of multidrug resistance: in vitro study.

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex.

Novel imino thioether complexes of platinum(II): synthesis, structural investigation, and biological activity.

Distinct translational control in CD4+ T cell subsets.

Cell biology. Trans-HSF1 express.

Novel mixed-ligand copper(I) complexes: role of diimine ligands on cytotoxicity and genotoxicity.

Advances in copper complexes as anticancer agents.

Synthesis and in vitro antitumor activity of water soluble sulfonate- and ester-functionalized silver(I) N-heterocyclic carbene complexes.

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

RACK1 Function in Cell Motility and Protein Synthesis.

Selenium induces a multi-targeted cell death process in addition to ROS formation.

Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase.

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

Largen: a molecular regulator of mammalian cell size control.

trans,cis,cis-Bis(benzoato)dichlorido(cyclohexane-1R,2R-diamine)platinum(IV): a Prodrug Candidate for the Treatment of Oxaliplatin-Refractory Colorectal Cancer.

Role of zinc trafficking in male fertility: from germ to sperm.

In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxilliary monodentate phosphine ligands.

Monofunctional Platinum(II) Complexes with Potent Tumor Cell Growth Inhibitory Activity: The Effect of a Hydrogen-Bond Donor/Acceptor N-Heterocyclic Ligand.