Marcin Paduch

The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif.

Bivalent peptides as models for multimeric targets of PDZ domains.

Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins.

Substance P derivatives as versatile tools for specific delivery of various types of biomolecular cargo.

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies.

Generating conformation-specific synthetic antibodies to trap proteins in selected functional states.

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.

Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.

Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.

Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies.

A Synthetic Antibody Fragment Targeting Nicastrin Affects Assembly and Trafficking of γ-Secretase.