Moses Rodriguez

Enzymatic properties of rat myelencephalon-specific protease.

Cellular sources and targets of IFN-gamma-mediated protection against viral demyelination and neurological deficits.

Human antibodies accelerate the rate of remyelination following lysolecithin-induced demyelination in mice.

Polyreactive antibodies to glatiramer acetate promote myelin repair in murine model of demyelinating disease.

Multiple sclerosis update.

Transgenic expression of Theiler's murine encephalomyelitis virus genes in H-2(b) mice inhibits resistance to virus-induced demyelination.

Direct evidence that a human antibody derived from patient serum can promote myelin repair in a mouse model of chronic-progressive demyelinating disease.

Impaired infiltration of tumor-specific cytolytic T cells in the absence of interferon-gamma despite their normal maturation in lymphoid organs during CD137 monoclonal antibody therapy.

Incidence of seizures in patients with multiple sclerosis: a population-based study.

Growth factor treatment of demyelinating disease: at last, a leap into the light.

ICAM-1 is crucial for protection from TMEV-induced neuronal damage but not demyelination.

Heterogeneity of pathogenesis in multiple sclerosis: implications for promotion of remyelination.

Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells.

Interleukin-6 protects anterior horn neurons from lethal virus-induced injury.

Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.

Remyelination-promoting antibodies activate distinct Ca2+ influx pathways in astrocytes and oligodendrocytes: relationship to the mechanism of myelin repair.

A function of myelin is to protect axons from subsequent injury: implications for deficits in multiple sclerosis.

HLA class II transgenic mice authenticate restriction of myelin oligodendrocyte glycoprotein-specific immune response implicated in multiple sclerosis pathogenesis.

More severe neurologic deficits in SJL/J male than female mice following Theiler's virus-induced CNS demyelination.

Efficient central nervous system remyelination requires T cells.

Membrane lymphotoxin is required for resistance to Theiler's virus infection.

Clearance of Theiler's virus infection depends on the ability to generate a CD8+ T cell response against a single immunodominant viral peptide.

Direct comparison of demyelinating disease induced by the Daniel's strain and BeAn strain of Theiler's murine encephalomyelitis virus.

Magnetic resonance imaging of immune cells in inflammation of central nervous system.

Gamma interferon is critical for neuronal viral clearance and protection in a susceptible mouse strain following early intracranial Theiler's murine encephalomyelitis virus infection.

In vivo magnetic resonance imaging of immune cells in the central nervous system with superparamagnetic antibodies.

A 40-cM region on chromosome 14 plays a critical role in the development of virus persistence, demyelination, brain pathology and neurologic deficits in a murine viral model of multiple sclerosis.

Human monoclonal IgM antibody promotes CNS myelin repair independent of Fc function.

Antibody-mediated remyelination operates through mechanism independent of immunomodulation.

The role of cellular immune response in Theiler's virus-induced central nervous system demyelination.

Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.

Scleromyxedema in a patient with multiple sclerosis and monoclonal gammopathy on interferon beta-1a.

Identification of T cell epitopes on human proteolipid protein and induction of experimental autoimmune encephalomyelitis in HLA class II-transgenic mice.

Disappearing "T1 black holes" in an animal model of multiple sclerosis.

Dynamics of MRI lesion development in an animal model of viral-induced acute progressive CNS demyelination.

Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.

Quality of life is favorable for most patients with multiple sclerosis: a population-based cohort study.

Neuron-binding human monoclonal antibodies support central nervous system neurite extension.

Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody.

Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.

Pulsed intravenous methylprednisolone therapy in progressive multiple sclerosis: need for a controlled trial.

CD4+ T cells are important for clearance of DA strain of TMEV from the central nervous system of SJL/J mice.

Clinical implications of benign multiple sclerosis: a 20-year population-based follow-up study.

A human antibody that promotes remyelination enters the CNS and decreases lesion load as detected by T2-weighted spinal cord MRI in a virus-induced murine model of MS.

Prevalence of tremor in multiple sclerosis and associated disability in the Olmsted County population.

Anatomical and cellular requirements for the activation and migration of virus-specific CD8+ T cells to the brain during Theiler's virus infection.

Genetically dominant spinal cord repair in a murine model of chronic progressive multiple sclerosis.

Inability of bm14 mice to respond to Theiler's murine encephalomyelitis virus is caused by defective antigen presentation, not repertoire selection.

Delineation of the minimal encephalitogenic epitope of proteolipid protein peptide(91-110) and critical residues required for induction of EAE in HLA-DR3 transgenic mice.

Neutralization of chemokines RANTES and MIG increases virus antigen expression and spinal cord pathology during Theiler's virus infection.

Magnetic resonance imaging, microscopy, and spectroscopy of the central nervous system in experimental animals.

Antigen-specific CD8+ T cells mediate a peptide-induced fatal syndrome.

Relation between humoral pathological changes in multiple sclerosis and response to therapeutic plasma exchange.

HLA DR and DQ interaction in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis in HLA class II transgenic mice.

STAT4- and STAT6-signaling molecules in a murine model of multiple sclerosis.

Later-onset Fabry disease: an adult variant presenting with the cramp-fasciculation syndrome.

Not every patient with multiple sclerosis should be treated at time of diagnosis.

Premenstrual multiple sclerosis pseudoexacerbations: Role of body temperature and prevention with aspirin.

Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1beta.

Disrupted spatial memory is a consequence of picornavirus infection.

MRI findings in benign multiple sclerosis are variable.

Multiple sclerosis, brain radiotherapy, and risk of neurotoxicity: the Mayo Clinic experience.

Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC.

Absence of perforin expression confers axonal protection despite demyelination.

Role of MHC class II expressing CD4+ T cells in proteolipid protein(91-110)-induced EAE in HLA-DR3 transgenic mice.

A recombinant human IgM promotes myelin repair after a single, very low dose.

A new humanized HLA transgenic mouse model of multiple sclerosis expressing class II on mouse CD4 T cells.

Genetic deletion of a single immunodominant T-cell response confers susceptibility to virus-induced demyelination.

Effectors of demyelination and remyelination in the CNS: implications for multiple sclerosis.

CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination.

Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination.

Tumor necrosis factor alpha is reparative via TNFR2 [corrected] in the hippocampus and via TNFR1 [corrected] in the striatum after virus-induced encephalitis.

HLA-DQ6 (DQB1*0601)-restricted T cells protect against experimental autoimmune encephalomyelitis in HLA-DR3.DQ6 double-transgenic mice by generating anti-inflammatory IFN-gamma.

Acute hemorrhagic demyelination in a murine model of multiple sclerosis.

Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration.

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice.

Invited article: human natural autoantibodies in the treatment of neurologic disease.

Demyelinated axons and motor function are protected by genetic deletion of perforin in a mouse model of multiple sclerosis.

Seizures in patients with multiple sclerosis: epidemiology, pathophysiology and management.

Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination.

Brainstem 1H nuclear magnetic resonance (NMR) spectroscopy: marker of demyelination and repair in spinal cord.

Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins.

Have we finally identified an autoimmune demyelinating disease?

Plasmonic nanohole arrays for label-free kinetic biosensing in a lipid membrane environment.

Cellular mechanisms of central nervous system repair by natural autoreactive monoclonal antibodies.

Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair.

Treatment of multiple sclerosis in children and adolescents.

Importance of oligodendrocyte protection, BBB breakdown and inflammation for remyelination.

Method of identifying natural antibodies for remyelination.

Retraction: Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells.

Retraction: Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody.

Retraction: TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

The relevance of animal models in multiple sclerosis research.

Novel roles of the picornaviral 3D polymerase in viral pathogenesis.

CD8+ T cells cause disability and axon loss in a mouse model of multiple sclerosis.

Antiviral effects of a transgenic RNA-dependent RNA polymerase.

Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity.

Multiple sclerosis therapies in pediatric patients with refractory multiple sclerosis.

MRI in rodent models of brain disorders.

Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis.

Beneficial plasma exchange response in central nervous system inflammatory demyelination.

Pediatric multiple sclerosis.

Autoantibodies with enzymatic properties in human autoimmune diseases.

Theiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy.

Enhancing CNS repair in neurological disease: challenges arising from neurodegeneration and rewiring of the network.

A human IgM signals axon outgrowth: coupling lipid raft to microtubules.

Facile assembly of micro- and nanoarrays for sensing with natural cell membranes.

Statin therapy and multiple sclerosis disability in a population-based cohort.

Evidence for the role of B cells and immunoglobulins in the pathogenesis of multiple sclerosis.

A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination.

Deletion of beta-2-microglobulin ameliorates spinal cord lesion load and promotes recovery of brainstem NAA levels in a murine model of multiple sclerosis.

Kallikrein 6 regulates early CNS demyelination in a viral model of multiple sclerosis.

Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity.

Need for a paradigm shift in therapeutic approaches to CNS injury.

Two discreet subsets of CD8 T cells modulate PLP(91-110) induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice.

Is multiple sclerosis an autoimmune disease?

Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis.

Remyelination induced by a DNA aptamer in a mouse model of multiple sclerosis.

High-affinity binding of remyelinating natural autoantibodies to myelin-mimicking lipid bilayers revealed by nanohole surface plasmon resonance.

Preclinical (1)H-MRS neurochemical profiling in neurological and psychiatric disorders.

Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?

Therapeutics to promote CNS repair: a natural human neuron-binding IgM regulates membrane-raft dynamics and improves motility in a mouse model of multiple sclerosis.

Cognitive impairment occurs in children and adolescents with multiple sclerosis: results from a United States network.

Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis.

PDGF is required for remyelination-promoting IgM stimulation of oligodendrocyte progenitor cell proliferation.

The road to remyelination in demyelinating diseases: current status and prospects for clinical treatment.

CD8(+) T cells in multiple sclerosis.

A patterned recombinant human IgM guides neurite outgrowth of CNS neurons.

Polyclonal and monoclonal antibodies in clinic.

Cellular targets and mechanistic strategies of remyelination-promoting IgMs as part of the naturally occurring autoantibody repertoire.

Quantitative MRI analysis in children with multiple sclerosis: a multicenter feasibility pilot study.

Applications of SPR for the characterization of molecules important in the pathogenesis and treatment of neurodegenerative diseases.

Differential expression of multiple kallikreins in a viral model of multiple sclerosis points to unique roles in the innate and adaptive immune response.

The US Network of Pediatric Multiple Sclerosis Centers: Development, Progress, and Next Steps.

Protective environmental factors for neuromyelitis optica.

Absence of IFN-γ increases brain pathology in experimental autoimmune encephalomyelitis-susceptible DRB1*0301.DQ8 HLA transgenic mice through secretion of proinflammatory cytokine IL-17 and induction of pathogenic monocytes/microglia into the central nervous system.

Deletion of Virus-specific T-cells Enhances Remyelination in a Model of Multiple Sclerosis.

Relapses and disability accumulation in progressive multiple sclerosis.

Quantitative PCR analysis of DNA aptamer pharmacokinetics in mice.

Ebola virus: melatonin as a readily available treatment option.

Human-derived natural antibodies: biomarkers and potential therapeutics.

Multiple sclerosis: the role of melatonin and N-acetylserotonin.

Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders.

A single dose of a neuron-binding human monoclonal antibody improves brainstem NAA concentrations, a biomarker for density of spinal cord axons, in a model of progressive multiple sclerosis.

Abbreviated exposure to hypoxia is sufficient to induce CNS dysmyelination, modulate spinal motor neuron composition, and impair motor development in neonatal mice.

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis.

Poor early relapse recovery affects onset of progressive disease course in multiple sclerosis.

Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases.

Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease.

Untargeted Plasma Metabolomics Identifies Endogenous Metabolite with Drug-like Properties in Chronic Animal Model of Multiple Sclerosis.

Antiviral Protection via RdRP-Mediated Stable Activation of Innate Immunity.

Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression.

Clinical features of neuromyelitis optica in children: US Network of Pediatric MS Centers report.

Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression.

Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis.

A case-control study of dietary salt intake in pediatric-onset multiple sclerosis.

A monoclonal natural human IgM protects axons in the absence of remyelination.