Ken Dower

T7 RNA polymerase-directed transcripts are processed in yeast and link 3' end formation to mRNA nuclear export.

Interactions between mRNA export commitment, 3'-end quality control, and nuclear degradation.

Early formation of mRNP: license for export or quality control?

A synthetic A tail rescues yeast nuclear accumulation of a ribozyme-terminated transcript.

Nonsense-mediated decay does not occur within the yeast nucleus.

3'-end formation signals modulate the association of genes with the nuclear periphery as well as mRNP dot formation.

Innate immune responses to TREM-1 activation: overlap, divergence, and positive and negative cross-talk with bacterial lipopolysaccharide.

TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines.

Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression.

Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library.

Stimulation of TLR4 by recombinant HSP70 requires structural integrity of the HSP70 protein itself.

Myxoma and vaccinia viruses bind differentially to human leukocytes.

The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner.