Colin W. Pouton

Pharmaceutical applications of embryonic stem cells.

Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system.

Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon.

Increasing the proportional content of surfactant (Cremophor EL) relative to lipid in self-emulsifying lipid-based formulations of danazol reduces oral bioavailability in beagle dogs.

Heterogeneous population of dopaminergic neurons derived from mouse embryonic stem cells: preliminary phenotyping based on receptor expression and function.

A microtubule-facilitated nuclear import pathway for cancer regulatory proteins.

Dynein light chain association sequences can facilitate nuclear protein import.

Embryonic stem cells as a source of models for drug discovery.

Targeted delivery to the nucleus.

Dual acting antioxidant A1 adenosine receptor agonists.

Evaluation of the impact of surfactant digestion on the bioavailability of danazol after oral administration of lipidic self-emulsifying formulations to dogs.

Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies.

Enhancing intestinal drug solubilisation using lipid-based delivery systems.

Preparation and in vitro evaluation of novel lipopeptide transfection agents for efficient gene delivery.

Design of lipid-based formulations for oral administration of poorly water-soluble drugs: precipitation of drug after dispersion of formulations in aqueous solution.

Structure and dynamics of glyceride lipid formulations, with propylene glycol and water.

Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.

A stably engineered, suicidal strain of listeria monocytogenes delivers protein and/or DNA to fully differentiated intestinal epithelial monolayers.

Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine.

Modulation of nucleocytoplasmic trafficking by retention in cytoplasm or nucleus.

Troubleshooting immunohistochemical labelling of proliferating cell nuclear antigen (PCNA) in cryocut tissue sections of mouse prostate.

Investigations into the binding affinities of different human 5-HT4 receptor splice variants.

Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists.

A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate.

Adenovirus: a blueprint for non-viral gene delivery.

Interaction of viruses with host cell molecular motors.

Cooperative cardioprotection through adenosine A1 and A2A receptor agonism in ischemia-reperfused isolated mouse heart.

Using polymeric precipitation inhibitors to improve the absorption of poorly water-soluble drugs: A mechanistic basis for utility.

Mechanism of microtubule-facilitated "fast track" nuclear import.

A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives.

Directed expression of Gata2, Mash1, and Foxa2 synergize to induce the serotonergic neuron phenotype during in vitro differentiation of embryonic stem cells.

Extended periods of neural induction and propagation of embryonic stem cell-derived neural progenitors with EGF and FGF2 enhances Lmx1a expression and neurogenic potential.

Commercially Supplied Amine-Modified siRNAs May Require Ultrafiltration prior to Conjugation with Amine-Reactive Compounds.

Using molecular dynamics to study liquid phase behavior: simulations of the ternary sodium laurate/sodium oleate/water system.

NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.

Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation.

In vitro maturation of dopaminergic neurons derived from mouse embryonic stem cells: implications for transplantation.

Synthesis and pharmacological evaluation of dual acting antioxidant A(2A) adenosine receptor agonists.

Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells.

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles across a range of representative formulations.

Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems.

Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N(6)-substituents as adenosine A(1) receptor agonists.

Colloidal characteristics and formulation of pure protein particulate vaccines.

Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug loading on the performance of type I, II, IIIA, IIIB, and IV formulations during in vitro digestion.

Synthesis and biological evaluation of N-substituted noscapine analogues.

In vitro digestion testing of lipid-based delivery systems: calcium ions combine with fatty acids liberated from triglyceride rich lipid solutions to form soaps and reduce the solubilization capacity of colloidal digestion products.

Strategies to address low drug solubility in discovery and development.

Evaluation of the structural determinants of polymeric precipitation inhibitors using solvent shift methods and principle component analysis.

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 3: understanding supersaturation versus precipitation potential during the in vitro digestion of type I, II, IIIA, IIIB and IV lipid-based formulations.

In vitro assessment of drug-free and fenofibrate-containing lipid formulations using dispersion and digestion testing gives detailed insights into the likely fate of formulations in the intestine.

Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.

Glyceride lipid formulations: molecular dynamics modeling of phase behavior during dispersion and molecular interactions between drugs and excipients.

DNA-dependent protein kinase is a context dependent regulator of Lmx1a and midbrain specification.

The synthesis and biological evaluation of multifunctionalised derivatives of noscapine as cytotoxic agents.

Choice of nonionic surfactant used to formulate type IIIA self-emulsifying drug delivery systems and the physicochemical properties of the drug have a pronounced influence on the degree of drug supersaturation that develops during in vitro digestion.

Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion.

Human leukocyte antigen haplotype phasing by allele-specific enrichment with peptide nucleic acid probes.

SIRPA, VCAM1 and CD34 identify discrete lineages during early human cardiovascular development.

Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system.

Digestion of phospholipids after secretion of bile into the duodenum changes the phase behavior of bile components.

'Stealth' lipid-based formulations: Poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug.