Joseph Loscalzo

Atherosclerotic Vascular Disease Conference: Executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association.

Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology.

Nitric oxide insufficiency and atherothrombosis.

L-arginine and atherothrombosis.

Pulmonary arterial hypertension.

Ethics and professionalism: can there be consensus? An editorial comment on the report of the ACCF/AHA Consensus Conference on Professionalism and Ethics.

Coronary calcium screening and the American Heart Association news embargo.

S-nitrosoprotein formation and localization in endothelial cells.

Molecular mechanisms underlying the proangiogenic effect of factor XIII.

Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation.

Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group.

Oxidative enzymopathies and vascular disease.

Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress.

Endogenous mechanisms of inhibition of platelet function.

Genetic determinants of vascular oxidant stress and endothelial dysfunction.

Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II.

Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice.

Cyclooxygenase inhibition and cardiovascular risk.

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice.

Clinical trials in cardiovascular medicine in an era of marginal benefit, bias, and hyperbole.

Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS.

Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation.

Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction.

Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice.

Evaluation of the pro-angiogenic effect of factor XIII in heterotopic mouse heart allografts and FXIII-deficient mice.

Homocysteine trials--clear outcomes for complex reasons.

Nitric oxide and posttranslational modification of the vascular proteome: S-nitrosation of reactive thiols.

Joseph Loscalzo, MD, PhD: a conversation with the Editor. Interview by William Clifford Roberts.

Pulmonary arterial hypertension.

The NIH budget and the future of biomedical research.

Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension.

Homocysteine.

Vascular calcification: pathobiological mechanisms and clinical implications.

Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children.

Predictors of improved left ventricular systolic function in an urban cardiomyopathy program.

Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity.

Effect of FXIII on monocyte and fibroblast function.

Entrepreneurship in the medical academy: possibilities and challenges in commercialization of research discoveries.

Regulation of the protein disulfide proteome by mitochondria in mammalian cells.

Human disease classification in the postgenomic era: a complex systems approach to human pathobiology.

Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure.

Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice.

Homocysteine and glutathione peroxidase-1.

The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event.

Frontiers in nephrology: targeting inflammation using novel nitric oxide donors.

Pathogenic mechanisms of pulmonary arterial hypertension.

Association studies in an era of too much information: clinical analysis of new biomarker and genetic data.

Should hyperhomocysteinemia be treated in patients with atherosclerotic disease?

Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis.

Redox regulation in the extracellular environment.

Task force 7: training in cardiovascular research.

Lipid levels after acute coronary syndromes.

Role of oxidative stress and nitric oxide in atherothrombosis.

Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice.

Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle.

Hepatocellular carcinoma with intracavitary cardiac involvement: a case report and review of the literature.

The treatment of hyperhomocysteinemia.

Membrane redox state and apoptosis: death by peroxide.

Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study.

Sleep and cardiovascular disease: an overview.

Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells.

Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells.

Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice.

Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses.

Pilot trials in clinical research: of what value are they?

A statement on ethics from the HEART Group.

Quo vadis: whither homocysteine research?

Clinical problem-solving. A fragile balance.

The effect of L-arginine and creatine on vascular function and homocysteine metabolism.

Oxidative risk for atherothrombotic cardiovascular disease.

Clinical problem-solving. The writing on the wall.

Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms.

Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria.

MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2.

Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study.

Homocysteine-mediated thrombosis and angiostasis in vascular pathobiology.

Clinical problem-solving. A bloody mystery.

The effect of salt on renal damage in eNOS-deficient mice.

Paraoxonase and coronary heart disease risk: language misleads, linkage misinforms, function clarifies.

High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis.

Clinical problem-solving. Painful purple toes.

Antioxidant enzyme deficiencies and vascular disease.

Clinical problem-solving. Stalking the diagnosis.

Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression.

MicroRNA-210: a unique and pleiotropic hypoxamir.

Evaluation of a redesign initiative in an internal-medicine residency.

Clinical problem-solving. The beat goes on.

Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model.

New section in Circulation: implications of contemporary clinical trials.

Nanoglycan complex formulation extends VEGF retention time in the lung.

Clinical problem-solving. A rash hypothesis.

Mechanism of disease: Pulmonary hypertension.

Clinical problem-solving. Hard to conceive.

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.

Reciprocal regulation of 11β-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro.

Clinical problem-solving. A heavy heart.

The cellular response to hypoxia: tuning the system with microRNAs.

Clinical problem-solving. Bitter pills.

Oxidative mechanisms and atherothrombotic cardiovascular disease.

Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities.

Network medicine: a network-based approach to human disease.

Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice.

Clinical problem-solving. A crazy cause of dyspnea.

Building a departmental quality program: a patient-based and provider-led approach.

The perils of combination antithrombotic therapy and potential resolutions.

The perils of combination antithrombotic therapy and potential resolutions.

Clinical problem-solving. Lying low.

Can scientific quality be quantified?

Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo.

Clinical problem-solving. A sweet source of abdominal pain.

Systems biology and personalized medicine: a network approach to human disease.

Evidence for human lung stem cells.

Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice.

Vascular Nitric Oxide: Formation and Function.

Epigenetic modifications: basic mechanisms and role in cardiovascular disease.

Clinical problem-solving. A sleeping giant.

Lipid metabolism by gut microbes and atherosclerosis.

Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation.

High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3.

Internal medicine residency redesign: proposal of the Internal Medicine Working Group.

Tissue-specific adult stem cells in the human lung.

Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification.

Systems biology and the future of medicine.

Genetically encoded fluorescent sensors for intracellular NADH detection.

Clinical problem-solving. A bird's-eye view of fever.

Redox regulation of mitochondrial function.

Physiological stress increases renal injury in eNOS-knockout mice.

Clinical problem-solving. Breathless.

Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress.

Personalized cardiovascular medicine and drug development: time for a new paradigm.

Clinical problem-solving. Worth a second look.

Comparison of lipid-modifying efficacy of rosuvastatin versus atorvastatin in patients with acute coronary syndrome (from the LUNAR study).

MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach.

Clinical problem-solving. A startling decline.

Deciphering the molecular basis of human cardiovascular disease through network biology.

Irreproducible experimental results: causes, (mis)interpretations, and consequences.

Regenerative pulmonary medicine: potential and promise, pitfalls and challenges.

Clinical problem-solving. Whistling in the dark.

Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine.

Homocysteine and cardiovascular risk: the perils of reductionism in a complex system.

Clinical problem-solving. At a loss.

S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system.

Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.

The emerging paradigm of network medicine in the study of human disease.

Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium.

Clinical problem-solving. Breathtaking journey.

Network medicine approaches to the genetics of complex diseases.

Cardiomyogenesis in the aging and failing human heart.

Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance.

Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study.

Clinical problem-solving. A complex cause of pleuritic chest pain.

Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension.

From clinical observation to mechanism--Heyde's syndrome.

Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose.

Alteration of relation of atherogenic lipoprotein cholesterol to apolipoprotein B by intensive statin therapy in patients with acute coronary syndrome (from the Limiting UNdertreatment of lipids in ACS With Rosuvastatin [LUNAR] Trial).

Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification.

Clinical problem-solving. The search is on.

From clinical observation to mechanism--Heyde's syndrome.

Selenistasis: epistatic effects of selenium on cardiovascular phenotype.

Venous thrombosis in the nephrotic syndrome.

Ever at the mercy of well-intentioned regulations: their adverse consequences and unproven benefits.

Gut microbiota, the genome, and diet in atherogenesis.

Clinical problem-solving. In the thick of it.

Editor's note.

Hypoxia: a master regulator of microRNA biogenesis and activity.

Pulmonary vascular disease related to hemodynamic stress in the pulmonary circulation.

Clinical problem-solving. Waiting for the other foot to drop.

Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials).

Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survival.

Clinical problem-solving. A patient with migrating polyarthralgias.

The identification of nitric oxide as endothelium-derived relaxing factor.

Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology.

Clinical problem-solving. A patient with syncope.

SDF-1α in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats.

Pulmonary hypertension: pathophysiology and signaling pathways.

Hypoxamirs and mitochondrial metabolism.

Clinical problem-solving. A curious case of chest pain.

Systems analysis of oxidant stress in the vasculature.

Clinical problem-solving. An unusual case of abdominal pain.

A celebration of failure.

Clinical problem-solving. Wasting away.

Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression.

Complexity and network dynamics in physiological adaptation: an integrated view.

Clinical problem-solving. Out of the blue.

Keshan disease, selenium deficiency, and the selenoproteome.

Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors.

DiseaseConnect: a comprehensive web server for mechanism-based disease-disease connections.

Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events.

Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD.

Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis.

Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series).

Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease.

Clinical problem-solving. A tight predicament.

A Division of Medical Communications in an academic medical center's Department of Medicine.

Clinical problem-solving. Against the grain.

Clinical problem-solving. A chilly fever.

A randomized trial of social media from circulation.

American heart association cardiovascular genome-phenome study: foundational basis and program.

Network-based association of hypoxia-responsive genes with cardiovascular diseases.