Laboratory of Membrane Trafficking Mechanisms,
Department of Developmental Biology and Neurosciences,
Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences
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Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells.
The Journal of biological chemistry Feb, 2002 | Pubmed ID: 11751925
The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11773082
Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport.
The Journal of biological chemistry Apr, 2002 | Pubmed ID: 11856727
Synaptotagmin V is targeted to dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells.
The Journal of biological chemistry Jul, 2002 | Pubmed ID: 12006594
The calcium-binding loops of the tandem C2 domains of synaptotagmin VII cooperatively mediate calcium-dependent oligomerization.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12034723
Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I.
The Journal of biological chemistry Aug, 2002 | Pubmed ID: 12048209
The C2A domain of synaptotagmin-like protein 3 (Slp3) is an atypical calcium-dependent phospholipid-binding machine: comparison with the C2A domain of synaptotagmin I.
The Biochemical journal Sep, 2002 | Pubmed ID: 12049610
Synaptotagmin-like protein 5: a novel Rab27A effector with C-terminal tandem C2 domains.
Biochemical and biophysical research communications May, 2002 | Pubmed ID: 12051743
Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis.
Neuron May, 2002 | Pubmed ID: 12062043
Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human.
The Biochemical journal Jul, 2002 | Pubmed ID: 12071850
Non-polarized distribution of synaptotagmin IV in neurons: evidence that synaptotagmin IV is not a synaptic vesicle protein.
Neuroscience research Aug, 2002 | Pubmed ID: 12135783
Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells.
The Journal of biological chemistry Oct, 2002 | Pubmed ID: 12176990
Synaptotagmin-like protein (Slp) homology domain 1 of Slac2-a/melanophilin is a critical determinant of GTP-dependent specific binding to Rab27A.
The Journal of biological chemistry Oct, 2002 | Pubmed ID: 12189142
Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin.
The Journal of biological chemistry Nov, 2002 | Pubmed ID: 12221080
Nerve growth factor-dependent sorting of synaptotagmin IV protein to mature dense-core vesicles that undergo calcium-dependent exocytosis in PC12 cells.
The Journal of biological chemistry Jan, 2003 | Pubmed ID: 12446703
Synaptotagmin I and IV are differentially regulated in the brain by the recreational drug 3,4-methylenedioxymethamphetamine (MDMA).
Brain research. Molecular brain research Dec, 2002 | Pubmed ID: 12480182
Characterization of the molecular defects in Rab27a, caused by RAB27A missense mutations found in patients with Griscelli syndrome.
The Journal of biological chemistry Mar, 2003 | Pubmed ID: 12531900
Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
The Journal of biological chemistry Apr, 2003 | Pubmed ID: 12578829
Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells.
The Journal of biological chemistry Apr, 2003 | Pubmed ID: 12590134
[Functional diversity of the synaptotagmin family].
Seikagaku. The Journal of Japanese Biochemical Society Dec, 2002 | Pubmed ID: 12607919
Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV.
Biochemical and biophysical research communications Jun, 2003 | Pubmed ID: 12788067
Characterization of a novel C. elegans RGS protein with a C2 domain: evidence for direct association between C2 domain and Galphaq subunit.
Life sciences Jul, 2003 | Pubmed ID: 12798417
Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans.
Journal of biochemistry May, 2003 | Pubmed ID: 12801916
The actin-binding domain of Slac2-a/melanophilin is required for melanosome distribution in melanocytes.
Molecular and cellular biology Aug, 2003 | Pubmed ID: 12861011
Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules.
Journal of cell science Nov, 2003 | Pubmed ID: 12966166
Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis.
Molecular biology of the cell Oct, 2003 | Pubmed ID: 14517322
Plasmalemmal sealing of transected mammalian neurites is a gradual process mediated by Ca(2+)-regulated proteins.
Journal of neuroscience research Nov, 2003 | Pubmed ID: 14598298
Munc13-4 is a GTP-Rab27-binding protein regulating dense core granule secretion in platelets.
The Journal of biological chemistry Mar, 2004 | Pubmed ID: 14699162
Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate.
The Journal of biological chemistry Mar, 2004 | Pubmed ID: 14709554
The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2004 | Pubmed ID: 14715936
Rabphilin and Noc2 are recruited to dense-core vesicles through specific interaction with Rab27A in PC12 cells.
The Journal of biological chemistry Mar, 2004 | Pubmed ID: 14722103
Missense mutations in the globular tail of myosin-Va in dilute mice partially impair binding of Slac2-a/melanophilin.
Journal of cell science Feb, 2004 | Pubmed ID: 14730011
RNA interference-mediated silencing of synaptotagmin IX, but not synaptotagmin I, inhibits dense-core vesicle exocytosis in PC12 cells.
The Biochemical journal Jun, 2004 | Pubmed ID: 15015935
The small GTPase Rab27B regulates amylase release from rat parotid acinar cells.
Journal of cell science Apr, 2004 | Pubmed ID: 15039459
Slac2-a/melanophilin contains multiple PEST-like sequences that are highly sensitive to proteolysis.
The Journal of biological chemistry May, 2004 | Pubmed ID: 15145961
Synaptotagmin V and IX isoforms control Ca2+ -dependent insulin exocytosis.
Journal of cell science Jul, 2004 | Pubmed ID: 15190121
Synaptotagmin IV regulates glial glutamate release.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2004 | Pubmed ID: 15197251
Alternative splicing in the first alpha-helical region of the Rab-binding domain of Rim regulates Rab3A binding activity: is Rim a Rab3 effector protein during evolution?
Genes to cells : devoted to molecular & cellular mechanisms Sep, 2004 | Pubmed ID: 15330860
Synaptotagmin VII is targeted to dense-core vesicles and regulates their Ca2+ -dependent exocytosis in PC12 cells.
The Journal of biological chemistry Dec, 2004 | Pubmed ID: 15456748
Effect of forskolin on synaptotagmin IV protein trafficking in PC12 cells.
Journal of biochemistry Aug, 2004 | Pubmed ID: 15496596
Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes.
Nature cell biology Dec, 2004 | Pubmed ID: 15543135
[Role of synaptotagmin and its related molecules in regulated secretion].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Nov, 2004 | Pubmed ID: 15559302
Vesicular reuptake inhibition by a synaptotagmin I C2B domain antibody at the squid giant synapse.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2004 | Pubmed ID: 15591349
Versatile role of Rab27 in membrane trafficking: focus on the Rab27 effector families.
Journal of biochemistry Jan, 2005 | Pubmed ID: 15713878
Classical protein kinase C(s) regulates targeting of synaptotagmin IX to the endocytic recycling compartment.
Journal of cell science Apr, 2005 | Pubmed ID: 15784685
Functional analysis of Slac2-c/MyRIP as a linker protein between melanosomes and myosin VIIa.
The Journal of biological chemistry Jul, 2005 | Pubmed ID: 15927964
AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain.
The Biochemical journal Oct, 2005 | Pubmed ID: 15971998
Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis.
Developmental biology Sep, 2005 | Pubmed ID: 16111671
[Role of synaptotagmin and its related molecules in membrane trafficking].
Seikagaku. The Journal of Japanese Biochemical Society Jul, 2005 | Pubmed ID: 16114843
The short apical membrane half-life of rescued {Delta}F508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of {Delta}F508-CFTR in polarized human airway epithelial cells.
The Journal of biological chemistry Nov, 2005 | Pubmed ID: 16131493
Adenovirus-mediated silencing of synaptotagmin 9 inhibits Ca2+-dependent insulin secretion in islets.
FEBS letters Sep, 2005 | Pubmed ID: 16165130
Slp4-a/granuphilin-a interacts with syntaxin-2/3 in a Munc18-2-dependent manner.
The Journal of biological chemistry Nov, 2005 | Pubmed ID: 16186111
The C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cells.
The Journal of biological chemistry Nov, 2005 | Pubmed ID: 16203731
Rab proteins regulate epithelial sodium channel activity in colonic epithelial HT-29 cells.
Biochemical and biophysical research communications Dec, 2005 | Pubmed ID: 16236259
Cloning and genomic characterization of sytdep, a new synaptotagmin XIV-related gene.
Biochemical and biophysical research communications Feb, 2006 | Pubmed ID: 16376304
Distinct developmental expression of synaptotagmin I and IX in the mouse brain.
Neuroreport Feb, 2006 | Pubmed ID: 16407767
Chronic olanzapine treatment causes differential expression of genes in frontal cortex of rats as revealed by DNA microarray technique.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Sep, 2006 | Pubmed ID: 16407901
Functional analysis of slac2-a/melanophilin as a linker protein between Rab27A and myosin Va in melanosome transport.
Methods in enzymology , 2005 | Pubmed ID: 16473608
Identification and biochemical analysis of Slac2-c/MyRIP as a Rab27A-, myosin Va/VIIa-, and actin-binding protein.
Methods in enzymology , 2005 | Pubmed ID: 16473609
Analysis of the role of Rab27 effector Slp4-a/Granuphilin-a in dense-core vesicle exocytosis.
Methods in enzymology , 2005 | Pubmed ID: 16473610
Assay and functional interactions of Rim2 with Rab3.
Methods in enzymology , 2005 | Pubmed ID: 16473611
Assay of the Rab-binding specificity of rabphilin and Noc2: target molecules for Rab27.
Methods in enzymology , 2005 | Pubmed ID: 16473612
The Slp4-a linker domain controls exocytosis through interaction with Munc18-1.syntaxin-1a complex.
Molecular biology of the cell May, 2006 | Pubmed ID: 16481396
Distinct Rab27A binding affinities of Slp2-a and Slac2-a/melanophilin: Hierarchy of Rab27A effectors.
Biochemical and biophysical research communications May, 2006 | Pubmed ID: 16554019
Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans.
Molecular biology of the cell Jun, 2006 | Pubmed ID: 16571673
Rab27a regulates epithelial sodium channel (ENaC) activity through synaptotagmin-like protein (SLP-5) and Munc13-4 effector mechanism.
Biochemical and biophysical research communications Jun, 2006 | Pubmed ID: 16630545
Rab3A and Rab27A cooperatively regulate the docking step of dense-core vesicle exocytosis in PC12 cells.
Journal of cell science Jun, 2006 | Pubmed ID: 16684812
Decreased basal mucus secretion by Slp2-a-deficient gastric surface mucous cells.
Genes to cells : devoted to molecular & cellular mechanisms Jun, 2006 | Pubmed ID: 16716193
Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta stimulate extracellular signal-regulated kinase 1/2 signaling by accelerating recycling through the endocytic recycling compartment.
Molecular biology of the cell Sep, 2006 | Pubmed ID: 16837555
Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets.
The Journal of biological chemistry Sep, 2006 | Pubmed ID: 16880209
Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity.
Genes to cells : devoted to molecular & cellular mechanisms Sep, 2006 | Pubmed ID: 16923123
Identification of EPI64 as a GTPase-activating protein specific for Rab27A.
The Journal of biological chemistry Oct, 2006 | Pubmed ID: 16923811
Functional involvement of Noc2, a Rab27 effector, in rat parotid acinar cells.
Archives of biochemistry and biophysics Nov, 2006 | Pubmed ID: 17067543
The polybasic sequence in the C2B domain of rabphilin is required for the vesicle docking step in PC12 cells.
Journal of neurochemistry Feb, 2007 | Pubmed ID: 17156129
Synaptotagmin (Syt) IX is an essential determinant for protein sorting to secretory granules in mast cells.
Blood Apr, 2007 | Pubmed ID: 17164344
Versatile roles of R-Ras GAP in neurite formation of PC12 cells and embryonic vascular development.
The Journal of biological chemistry Feb, 2007 | Pubmed ID: 17179160
Dvl regulates endo- and exocytotic processes through binding to synaptotagmin.
Genes to cells : devoted to molecular & cellular mechanisms Jan, 2007 | Pubmed ID: 17212654
Synaptotagmin I binds intestinal epithelial NHE3 and mediates cAMP- and Ca2+-induced endocytosis by recruitment of AP2 and clathrin.
American journal of physiology. Gastrointestinal and liver physiology Jun, 2007 | Pubmed ID: 17307723
Up-regulation of ras-GAP genes is reversed by a MEK inhibitor and doxorubicin in v-Ki-ras-transformed NIH/3T3 fibroblasts.
Biochemical and biophysical research communications May, 2007 | Pubmed ID: 17367762
Synaptotagmin VII modulates the kinetics of dense-core vesicle exocytosis in PC12 cells.
Genes to cells : devoted to molecular & cellular mechanisms Apr, 2007 | Pubmed ID: 17397398
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.
Cell metabolism Apr, 2007 | Pubmed ID: 17403373
Myosin Vb is required for trafficking of the cystic fibrosis transmembrane conductance regulator in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells.
The Journal of biological chemistry Aug, 2007 | Pubmed ID: 17462998
Cholesterol controls lipid endocytosis through Rab11.
Molecular biology of the cell Jul, 2007 | Pubmed ID: 17475773
Spatial segregation of degradation- and recycling-trafficking pathways in COS-1 cells.
Biochemical and biophysical research communications Aug, 2007 | Pubmed ID: 17606221
Synaptotagmin VII splice variants alpha, beta, and delta are expressed in pancreatic beta-cells and regulate insulin exocytosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Jan, 2008 | Pubmed ID: 17709608
JNK phosphorylates synaptotagmin-4 and enhances Ca2+-evoked release.
The EMBO journal Jan, 2008 | Pubmed ID: 18046461
Increased plasma membrane localization of O-glycosylation-deficient mutant of synaptotagmin I in PC12 cells.
Journal of neuroscience research Apr, 2008 | Pubmed ID: 18058942
Rab10 in insulin-stimulated GLUT4 translocation.
The Biochemical journal Apr, 2008 | Pubmed ID: 18076383
[Specificity and diversity of Rab family GTPases in membrane traffic].
Seikagaku. The Journal of Japanese Biochemical Society Nov, 2007 | Pubmed ID: 18095458
The primate-specific protein TBC1D3 is required for optimal macropinocytosis in a novel ARF6-dependent pathway.
Molecular biology of the cell Apr, 2008 | Pubmed ID: 18199687
Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity.
Molecular & cellular proteomics : MCP Jun, 2008 | Pubmed ID: 18256213
Human RME-8 is involved in membrane trafficking through early endosomes.
Cell structure and function , 2008 | Pubmed ID: 18256511
Slp1 and Slp2-a localize to the plasma membrane of CTL and contribute to secretion from the immunological synapse.
Traffic (Copenhagen, Denmark) Apr, 2008 | Pubmed ID: 18266782
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.
Molecular biology of the cell May, 2008 | Pubmed ID: 18321988
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation.
Molecular biology of the cell Jul, 2008 | Pubmed ID: 18448665
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
The Journal of biological chemistry Jun, 2008 | Pubmed ID: 18450757
Expression of Rab27B-binding protein Slp1 in pancreatic acinar cells and its involvement in amylase secretion.
Archives of biochemistry and biophysics Jul, 2008 | Pubmed ID: 18477466
Direct link between Atg protein and small GTPase Rab: Atg16L functions as a potential Rab33 effector in mammals.
Autophagy Aug, 2008 | Pubmed ID: 18670194
Rab27a regulates exocytosis of tertiary and specific granules in human neutrophils.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2008 | Pubmed ID: 18768832
Dysferlin deficiency shows compensatory induction of Rab27A/Slp2a that may contribute to inflammatory onset.
The American journal of pathology Nov, 2008 | Pubmed ID: 18832576
The exocytosis regulator synaptotagmin V controls phagocytosis in macrophages.
Journal of immunology (Baltimore, Md. : 1950) Oct, 2008 | Pubmed ID: 18832684
Role of Rab27 in synaptic transmission at the squid giant synapse.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2008 | Pubmed ID: 18840683
Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases.
Structure (London, England : 1993) Oct, 2008 | Pubmed ID: 18940604
Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.
Genes to cells : devoted to molecular & cellular mechanisms Jan, 2009 | Pubmed ID: 19077034
Redistribution of Rab27-specific effector Slac2-c, but not Slp4-a, after isoproterenol-stimulation in rat parotid acinar cells.
Archives of oral biology Apr, 2009 | Pubmed ID: 19185850
The drs tumor suppressor is involved in the maturation process of autophagy induced by low serum.
Cancer letters Sep, 2009 | Pubmed ID: 19368996
Varp is a novel Rab32/38-binding protein that regulates Tyrp1 trafficking in melanocytes.
Molecular biology of the cell Jun, 2009 | Pubmed ID: 19403694
Regulation of the intracellular distribution, cell surface expression, and protein levels of AMPA receptor GluR2 subunits by the monocarboxylate transporter MCT2 in neuronal cells.
Journal of neurochemistry Jun, 2009 | Pubmed ID: 19457092
Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
Developmental cell May, 2009 | Pubmed ID: 19460344
Redistribution of small GTP-binding protein, Rab27B, in rat parotid acinar cells after stimulation with isoproterenol.
European journal of oral sciences Jun, 2009 | Pubmed ID: 19583748
A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).
The Journal of biological chemistry Sep, 2009 | Pubmed ID: 19643732
The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V.
PLoS pathogens Oct, 2009 | Pubmed ID: 19834555
Age-dependent preferential dense-core vesicle exocytosis in neuroendocrine cells revealed by newly developed monomeric fluorescent timer protein.
Molecular biology of the cell Jan, 2010 | Pubmed ID: 19889833
Rab27a and Rab27b control different steps of the exosome secretion pathway.
Nature cell biology Jan, 2010 | Pubmed ID: 19966785
BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.
PLoS pathogens Dec, 2009 | Pubmed ID: 20019814
Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs.
Traffic (Copenhagen, Denmark) Apr, 2010 | Pubmed ID: 20070612
Broad-minded links cell cycle-related kinase to cilia assembly and hedgehog signal transduction.
Developmental cell Feb, 2010 | Pubmed ID: 20159594
Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis.
The EMBO journal May, 2010 | Pubmed ID: 20360680
Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2.
Pigment cell & melanoma research Jun, 2010 | Pubmed ID: 20370853
Role of the polybasic sequence in the Doc2alpha C2B domain in dense-core vesicle exocytosis in PC12 cells.
Journal of neurochemistry Jul, 2010 | Pubmed ID: 20403080
Phosphorylation of AATYK1 by Cdk5 suppresses its tyrosine phosphorylation.
PloS one , 2010 | Pubmed ID: 20422042
Storage of GABA in chromaffin granules and not in synaptic-like microvesicles in rat adrenal medullary cells.
Journal of neurochemistry Jul, 2010 | Pubmed ID: 20477909
AATYK1A phosphorylation by Cdk5 regulates the recycling endosome pathway.
Genes to cells : devoted to molecular & cellular mechanisms Jun, 2010 | Pubmed ID: 20553326
How can mammalian Rab small GTPases be comprehensively analyzed?: Development of new tools to comprehensively analyze mammalian Rabs in membrane traffic.
Histology and histopathology Nov, 2010 | Pubmed ID: 20865669
[Rab small GTPases and their effectors].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Dec, 2008 | Pubmed ID: 21038586
Synaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosis.
Neurochemical research Jul, 2011 | Pubmed ID: 21153436
Structure-function analysis of VPS9-ankyrin-repeat protein (Varp) in the trafficking of tyrosinase-related protein 1 in melanocytes.
The Journal of biological chemistry Mar, 2011 | Pubmed ID: 21187289
TBC proteins: GAPs for mammalian small GTPase Rab?
Bioscience reports Jun, 2011 | Pubmed ID: 21250943
Differential distribution of synaptotagmin-1, -4, -7, and -9 in rat adrenal chromaffin cells.
Cell and tissue research Apr, 2011 | Pubmed ID: 21287204
The recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking.
Traffic (Copenhagen, Denmark) May, 2011 | Pubmed ID: 21291502
OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.
The Journal of cell biology Mar, 2011 | Pubmed ID: 21383079
Dissociation of inositol polyphosphates from the C2B domain of synaptotagmin facilitates spontaneous release of catecholamines in adrenal chromaffin cells. A suggestive evidence of a fusion clamp by synaptotagmin.
Neuropharmacology Jun, 2011 | Pubmed ID: 21402086
A possible role of Atg8 homologs as a scaffold for signal transduction.
Autophagy Sep, 2011 | Pubmed ID: 21597320
Exclusion of synaptotagmin V at the phagocytic cup by Leishmania donovani lipophosphoglycan results in decreased promastigote internalization.
Microbiology (Reading, England) Sep, 2011 | Pubmed ID: 21680635
Small GTPase Rab12 regulates constitutive degradation of transferrin receptor.
Traffic (Copenhagen, Denmark) Oct, 2011 | Pubmed ID: 21718402
Genome-wide investigation of the Rab binding activity of RUN domains: development of a novel tool that specifically traps GTP-Rab35.
Cell structure and function , 2011 | Pubmed ID: 21737958
Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells.
American journal of physiology. Lung cellular and molecular physiology Oct, 2011 | Pubmed ID: 21764986
EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells.
The Journal of biological chemistry Sep, 2011 | Pubmed ID: 21832089
Exome sequencing reveals a homozygous SYT14 mutation in adult-onset, autosomal-recessive spinocerebellar ataxia with psychomotor retardation.
American journal of human genetics Aug, 2011 | Pubmed ID: 21835308
Molecular mechanism of myosin Va recruitment to dense core secretory granules.
Traffic (Copenhagen, Denmark) Jan, 2012 | Pubmed ID: 21985333
Rab35 regulates phagosome formation through recruitment of ACAP2 in macrophages during FcγR-mediated phagocytosis.
Journal of cell science Nov, 2011 | Pubmed ID: 22045739
Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex.
Autophagy Dec, 2011 | Pubmed ID: 22082872
The Rab21-GEF activity of Varp, but not its Rab32/38 effector function, is required for dendrite formation in melanocytes.
Molecular biology of the cell Feb, 2012 | Pubmed ID: 22171327
An ARF6/Rab35 GTPase cascade for endocytic recycling and successful cytokinesis.
Current biology : CB Jan, 2012 | Pubmed ID: 22226746
Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Journal of cell science Mar, 2012 | Pubmed ID: 22275436
Small GTPase Rab12 regulates transferrin receptor degradation: Implications for a novel membrane trafficking pathway from recycling endosomes to lysosomes.
Cellular logistics 7, 2011 | Pubmed ID: 22279614
Small GTPase Rab17 regulates dendritic morphogenesis and postsynaptic development of hippocampal neurons.
The Journal of biological chemistry Mar, 2012 | Pubmed ID: 22291024
Phospholipase C-related, but catalytically inactive protein PRIP modulates SNAP-25 phosphorylation and exocytosis.
The Journal of biological chemistry Feb, 2012 | Pubmed ID: 22311984
Role of Rab family GTPases and their effectors in melanosomal logistics.
Journal of biochemistry Apr, 2012 | Pubmed ID: 22323658
Rab35 regulates Arf6 activity through centaurin-β2 (ACAP2) during neurite outgrowth.
Journal of cell science May, 2012 | Pubmed ID: 22344257
LMTK1/AATYK1 is a novel regulator of axonal outgrowth that acts via Rab11 in a Cdk5-dependent manner.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2012 | Pubmed ID: 22573681
Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity.
Molecular biology of the cell Aug, 2012 | Pubmed ID: 22740627
The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
The Journal of biological chemistry Aug, 2012 | Pubmed ID: 22740695
Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression.
Molecular biology of the cell Aug, 2012 | Pubmed ID: 22767581
Synaptotagmin-like proteins control the formation of a single apical membrane domain in epithelial cells.
Nature cell biology Aug, 2012 | Pubmed ID: 22820376
Intracellular trafficking of Clostridium perfringens iota-toxin b.
Infection and immunity Oct, 2012 | Pubmed ID: 22825447
Decoding the regulation of mast cell exocytosis by networks of Rab GTPases.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2012 | Pubmed ID: 22826321
Essential role of RAB27A in determining constitutive human skin color.
PloS one , 2012 | Pubmed ID: 22844437
Functional involvement of Rab1A in microtubule-dependent anterograde melanosome transport in melanocytes.
Journal of cell science Nov, 2012 | Pubmed ID: 22854043
A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis.
Journal of cell science Oct, 2012 | Pubmed ID: 22899725
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy Apr, 2012 | Pubmed ID: 22966490
Rab33a mediates anterograde vesicular transport for membrane exocytosis and axon outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2012 | Pubmed ID: 22972995
Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology.
Journal of cell science Jan, 2013 | Pubmed ID: 23077178
All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras.
Journal of biochemistry Mar, 2013 | Pubmed ID: 23248241
Synaptotagmin XI regulates phagocytosis and cytokine secretion in macrophages.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2013 | Pubmed ID: 23303671
Rabex-5 protein regulates dendritic localization of small GTPase Rab17 and neurite morphogenesis in hippocampal neurons.
The Journal of biological chemistry Apr, 2013 | Pubmed ID: 23430262
NDR2-mediated Rabin8 phosphorylation is crucial for ciliogenesis by switching binding specificity from phosphatidylserine to Sec15.
The EMBO journal Mar, 2013 | Pubmed ID: 23435566
Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4.
EMBO reports May, 2013 | Pubmed ID: 23478338
Dab1-mediated colocalization of multi-adaptor protein CIN85 with Reelin receptors, ApoER2 and VLDLR, in neurons.
Genes to cells : devoted to molecular & cellular mechanisms May, 2013 | Pubmed ID: 23506116
[Slp2-a transports the apical signaling molecule podocalyxin to the apical surface and affects cell-cell interactions].
Seikagaku. The Journal of Japanese Biochemical Society Feb, 2013 | Pubmed ID: 23539965
Syntaxin-3 is required for melanosomal localization of Tyrp1 in melanocytes.
The Journal of investigative dermatology Sep, 2013 | Pubmed ID: 23549422
Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.
Journal of cell science Jun, 2013 | Pubmed ID: 23572513
Small GTPase Rab39A interacts with UACA and regulates the retinoic acid-induced neurite morphology of Neuro2A cells.
Biochemical and biophysical research communications May, 2013 | Pubmed ID: 23624502
The extra-cellular signal regulated kinases ERK1 and ERK2 segregate displaying distinct spatiotemporal characteristics in activated mast cells.
Biochimica et biophysica acta Sep, 2013 | Pubmed ID: 23651922
Rab27 effectors, pleiotropic regulators in secretory pathways.
Traffic (Copenhagen, Denmark) Sep, 2013 | Pubmed ID: 23678941
MADD/DENN/Rab3GEP functions as a guanine nucleotide exchange factor for Rab27 during granule exocytosis of rat parotid acinar cells.
Archives of biochemistry and biophysics Aug, 2013 | Pubmed ID: 23702376
The GTPase Rab37 Participates in the Control of Insulin Exocytosis.
PloS one , 2013 | Pubmed ID: 23826383
Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.
The Journal of cell biology Oct, 2013 | Pubmed ID: 24100292
Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis.
Cell cycle (Georgetown, Tex.) Jan, 2014 | Pubmed ID: 24196446
Arf6, Rab11 and transferrin receptor define distinct populations of recycling endosomes.
Communicative & integrative biology Sep, 2013 | Pubmed ID: 24255739
Rabex-5 determines the neurite localization of its downstream Rab proteins in hippocampal neurons.
Communicative & integrative biology Sep, 2013 | Pubmed ID: 24265856
Slp2-a controls renal epithelial cell size through regulation of Rap-ezrin signaling independently of Rab27.
Journal of cell science Feb, 2014 | Pubmed ID: 24284068
Methods of analysis of the membrane trafficking pathway from recycling endosomes to lysosomes.
Methods in enzymology , 2014 | Pubmed ID: 24359955
The GTPase-deficient Rab27A(Q78L) mutant inhibits melanosome transport in melanocytes through trapping of Rab27A effector protein Slac2-a/melanophilin in their cytosol: development of a novel melanosome-targetinG tag.
The Journal of biological chemistry Apr, 2014 | Pubmed ID: 24584932
LMTK1 regulates dendritic formation by regulating movement of Rab11A-positive endosomes.
Molecular biology of the cell Jun, 2014 | Pubmed ID: 24672056
Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis.
Journal of immunology (Baltimore, Md. : 1950) May, 2014 | Pubmed ID: 24696234
Dennd3 functions as a guanine nucleotide exchange factor for small GTPase Rab12 in mouse embryonic fibroblasts.
The Journal of biological chemistry May, 2014 | Pubmed ID: 24719330
Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24831002
Rab35 is translocated from Arf6-positive perinuclear recycling endosomes to neurite tips during neurite outgrowth.
Small GTPases , 2014 | Pubmed ID: 24852758
Small GTPase Rab17 regulates the surface expression of kainate receptors but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein.
The Journal of biological chemistry Jul, 2014 | Pubmed ID: 24895134
Atmospheric scanning electron microscope system with an open sample chamber: configuration and applications.
Ultramicroscopy Dec, 2014 | Pubmed ID: 25062041
Leishmania promastigotes induce cytokine secretion in macrophages through the degradation of synaptotagmin XI.
Journal of immunology (Baltimore, Md. : 1950) Sep, 2014 | Pubmed ID: 25063865
Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.
Science signaling , 2014 | Pubmed ID: 25074980
Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth.
Biology open , 2014 | Pubmed ID: 25086062
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.
Molecular biology of the cell Nov, 2014 | Pubmed ID: 25232007
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.
Journal of cell science Nov, 2014 | Pubmed ID: 25278552
Rab1A regulates anterograde melanosome transport by recruiting kinesin-1 to melanosomes through interaction with SKIP.
Scientific reports Feb, 2015 | Pubmed ID: 25649263
Rab40C is a novel Varp-binding protein that promotes proteasomal degradation of Varp in melanocytes.
Biology open Feb, 2015 | Pubmed ID: 25661869
Structure-function analyses of the small GTPase Rab35 and its effector protein centaurin-β2/ACAP2 during neurite outgrowth of PC12 cells.
The Journal of biological chemistry Apr, 2015 | Pubmed ID: 25694427
Rabin8 suppresses autophagosome formation independently of its guanine nucleotide-exchange activity towards Rab8.
Journal of biochemistry Aug, 2015 | Pubmed ID: 25787272
Functional analysis of Rab27A and its effector Slp2-a in renal epithelial cells.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25800838
Measurement of Rab35 activity with the GTP-Rab35 trapper RBD35.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25800845
Assay of Rab17 and its guanine nucleotide exchange factor Rabex-5 in the dendrites of hippocampal neurons.
Methods in molecular biology (Clifton, N.J.) , 2015 | Pubmed ID: 25800847
Slp2-a inactivates ezrin by recruiting protein phosphatase 1 to the plasma membrane.
Biochemical and biophysical research communications May, 2015 | Pubmed ID: 25817786
The small GTPase Rab33A participates in regulation of amylase release from parotid acinar cells.
Biochemical and biophysical research communications Jun, 2015 | Pubmed ID: 25871792
Rab27A regulates transport of cell surface receptors modulating multinucleation and lysosome-related organelles in osteoclasts.
Scientific reports Apr, 2015 | Pubmed ID: 25882854
Small GTPase Rab2B and Its Specific Binding Protein Golgi-associated Rab2B Interactor-like 4 (GARI-L4) Regulate Golgi Morphology.
The Journal of biological chemistry Sep, 2015 | Pubmed ID: 26209634
Activation-Inactivation Cycling of Rab35 and ARF6 Is Required for Phagocytosis of Zymosan in RAW264 Macrophages.
Journal of immunology research , 2015 | Pubmed ID: 26229970
RUTBC1 Functions as a GTPase-activating Protein for Rab32/38 and Regulates Melanogenic Enzyme Trafficking in Melanocytes.
The Journal of biological chemistry Jan, 2016 | Pubmed ID: 26620560
Mon1-Ccz1 activates Rab7 only on late endosomes and dissociates from the lysosome in mammalian cells.
Journal of cell science Jan, 2016 | Pubmed ID: 26627821
Rab12 Regulates Retrograde Transport of Mast Cell Secretory Granules by Interacting with the RILP-Dynein Complex.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2016 | Pubmed ID: 26740112
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy Jan, 2016 | Pubmed ID: 26799652
Differing susceptibility to autophagic degradation of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1.
Autophagy , 2016 | Pubmed ID: 26902585
Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells.
Molecular biology of the cell May, 2016 | Pubmed ID: 27009205
P53- and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance.
The Journal of cell biology Apr, 2016 | Pubmed ID: 27044891
A Varp-Binding Protein, RACK1, Regulates Dendrite Outgrowth through Stabilization of Varp Protein in Mouse Melanocytes.
The Journal of investigative dermatology 08, 2016 | Pubmed ID: 27066885
Multiple Roles of VARP in Endosomal Trafficking: Rabs, Retromer Components and R-SNARE VAMP7 Meet on VARP.
Traffic (Copenhagen, Denmark) 07, 2016 | Pubmed ID: 27103185
Regulation of podocalyxin trafficking by Rab small GTPases in 2D and 3D epithelial cell cultures.
The Journal of cell biology 05, 2016 | Pubmed ID: 27138252
Rabin8 regulates neurite outgrowth in both GEF activity-dependent and -independent manners.
Molecular biology of the cell 07, 2016 | Pubmed ID: 27170183
Release of Infectious Hepatitis C Virus from Huh7 Cells Occurs via a trans-Golgi Network-to-Endosome Pathway Independent of Very-Low-Density Lipoprotein Secretion.
Journal of virology 08, 2016 | Pubmed ID: 27226379
Multiple Types of Guanine Nucleotide Exchange Factors (GEFs) for Rab Small GTPases.
Cell structure and function Jul, 2016 | Pubmed ID: 27246931
Rab35 Functions in Axon Elongation Are Regulated by P53-Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule-Associated Protein 1B.
The Journal of neuroscience : the official journal of the Society for Neuroscience 07, 2016 | Pubmed ID: 27383602
Rab3A, a possible marker of cortical granules, participates in cortical granule exocytosis in mouse eggs.
Experimental cell research 09, 2016 | Pubmed ID: 27423421
Regulation of podocalyxin trafficking by Rab small GTPases in epithelial cells.
Small GTPases Oct, 2016 | Pubmed ID: 27463697
Acute accumulation of free cholesterol induces the degradation of perilipin 2 and Rab18-dependent fusion of ER and lipid droplets in cultured human hepatocytes.
Molecular biology of the cell Nov, 2016 | Pubmed ID: 27582390
Genetic screen in Drosophila muscle identifies autophagy-mediated T-tubule remodeling and a Rab2 role in autophagy.
eLife Jan, 2017 | Pubmed ID: 28063257
Cdk5 Regulation of the GRAB-Mediated Rab8-Rab11 Cascade in Axon Outgrowth.
The Journal of neuroscience : the official journal of the Society for Neuroscience 01, 2017 | Pubmed ID: 28123016
Parkin promotes proteasomal degradation of synaptotagmin IV by accelerating polyubiquitination.
Molecular and cellular neurosciences 04, 2017 | Pubmed ID: 28254618
C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia.
Brain : a journal of neurology Apr, 2017 | Pubmed ID: 28334866
TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells.
PloS one , 2017 | Pubmed ID: 28384198
Rab32 subfamily small GTPases: pleiotropic Rabs in endosomal trafficking.
Journal of biochemistry Aug, 2017 | Pubmed ID: 28430987
The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.
Cell reports Sep, 2017 | Pubmed ID: 28930687
The GTPase Rab43 Controls the Anterograde ER-Golgi Trafficking and Sorting of GPCRs.
Cell reports Oct, 2017 | Pubmed ID: 29069590
Rab20, a novel Rab small GTPase that negatively regulates neurite outgrowth of PC12 cells.
Neuroscience letters Jan, 2018 | Pubmed ID: 29107708
Rab5 is critical for SNAP23 regulated granule-granule fusion during compound exocytosis.
Scientific reports Nov, 2017 | Pubmed ID: 29127297
Parkinson's disease-linked DNAJC13 mutation aggravates alpha-synuclein-induced neurotoxicity through perturbation of endosomal trafficking.
Human molecular genetics Mar, 2018 | Pubmed ID: 29309590
Rab7 knockout unveils regulated autolysosome maturation induced by glutamine starvation.
Journal of cell science Apr, 2018 | Pubmed ID: 29514857
Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination.
Cellular microbiology Mar, 2018 | Pubmed ID: 29582580
1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University,
2Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine,
3Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University
Ofir Klein1,
Amit Roded1,
Koret Hirschberg2,
Mitsunori Fukuda3,
Stephen J. Galli4,
Ronit Sagi-Eisenberg1
1Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University,
2Department of Pathology, Sackler Faculty of Medicine, Tel Aviv University,
3Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University,
4Departments of Pathology and of Microbiology and Immunology and Sean N. Parker Center for Allergy and Asthma Research, School of Medicine, Stanford University