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Department of Pathology and Cell Biology,
Center for Motor Neuron Biology and Disease
Hynek Wichterle has not added Biography.
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Directed differentiation of embryonic stem cells into motor neurons.
Cell Aug, 2002 | Pubmed ID: 12176325
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.
Journal of biology Nov, 2002 | Pubmed ID: 12437772
Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2003 | Pubmed ID: 12515855
Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2003 | Pubmed ID: 12679522
A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification.
Neuron Sep, 2003 | Pubmed ID: 14527435
Functional properties of motoneurons derived from mouse embryonic stem cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2004 | Pubmed ID: 15356197
New neurons follow the flow of cerebrospinal fluid in the adult brain.
Science (New York, N.Y.) Feb, 2006 | Pubmed ID: 16410488
Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2006 | Pubmed ID: 16432183
Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience Aug, 2006 | Pubmed ID: 16914688
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.
Nature neuroscience May, 2007 | Pubmed ID: 17435755
Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.
Science (New York, N.Y.) Aug, 2008 | Pubmed ID: 18669821
Differentiation of mouse embryonic stem cells to spinal motor neurons.
Current protocols in stem cell biology May, 2008 | Pubmed ID: 18770634
Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord.
Methods in molecular biology (Clifton, N.J.) , 2009 | Pubmed ID: 19089356
Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding.
Lab on a chip Apr, 2010 | Pubmed ID: 20358107
What can pluripotent stem cells teach us about neurodegenerative diseases?
Nature neuroscience Jul, 2010 | Pubmed ID: 20581816
Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation.
Cell stem cell Sep, 2010 | Pubmed ID: 20804971
Global control of motor neuron topography mediated by the repressive actions of a single hox gene.
Neuron Sep, 2010 | Pubmed ID: 20826310
Programming embryonic stem cells to neuronal subtypes.
Current opinion in neurobiology Feb, 2011 | Pubmed ID: 20970319
MicroRNA regulation of neural stem cells and neurogenesis.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2010 | Pubmed ID: 21068294
Ligand-dependent dynamics of retinoic acid receptor binding during early neurogenesis.
Genome biology , 2011 | Pubmed ID: 21232103
A functionally characterized test set of human induced pluripotent stem cells.
Nature biotechnology Mar, 2011 | Pubmed ID: 21293464
Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop.
Neuron Feb, 2011 | Pubmed ID: 21338882
An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.
Cell Sep, 2011 | Pubmed ID: 21924763
Embryonic stem cell-based mapping of developmental transcriptional programs.
Nature methods Dec, 2011 | Pubmed ID: 22081127
Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2012 | Pubmed ID: 22279234
College of Physicians and Surgeons, Columbia University
Zaman Mirzadeh1,
Fiona Doetsch2,3,
Kazunobu Sawamoto4,
Hynek Wichterle2,5,
Arturo Alvarez-Buylla1
1Department of Neurosurgery, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco - UCSF,
2Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University,
3Department of Neuroscience and Neurology, College of Physicians and Surgeons, Columbia University,
4Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences,
5Center for Motor Neuron Biology and Disease, College of Physicians and Surgeons, Columbia University
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