Department of Radiation and Cellular Oncology,
Department of Molecular Genetics and Cell Biology
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RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient breast tumors.
Cancer research Oct, 2007 | Pubmed ID: 17942895
Crossover interference in Saccharomyces cerevisiae requires a TID1/RDH54- and DMC1-dependent pathway.
Genetics Apr, 2003 | Pubmed ID: 12702674
Monitoring changes in the subcellular location of proteins in S. cerevisiae.
Methods in molecular biology (Clifton, N.J.) , 2004 | Pubmed ID: 14970663
Early decision; meiotic crossover interference prior to stable strand exchange and synapsis.
Cell Apr, 2004 | Pubmed ID: 15066278
A hot spot for RAD51C interactions revealed by a peptide that sensitizes cells to cisplatin.
Cancer research May, 2004 | Pubmed ID: 15126333
Heterodimeric complexes of Hop2 and Mnd1 function with Dmc1 to promote meiotic homolog juxtaposition and strand assimilation.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2004 | Pubmed ID: 15249670
Calcium ion promotes yeast Dmc1 activity via formation of long and fine helical filaments with single-stranded DNA.
The Journal of biological chemistry Dec, 2005 | Pubmed ID: 16204247
Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.
Cancer research Dec, 2005 | Pubmed ID: 16357182
Red-Hed regulation: recombinase Rad51, though capable of playing the leading role, may be relegated to supporting Dmc1 in budding yeast meiosis.
Genes & development Jul, 2006 | Pubmed ID: 16818601
Tid1/Rdh54 promotes dissociation of Dmc1 from nonrecombinogenic sites on meiotic chromatin.
Genes & development Sep, 2006 | Pubmed ID: 16980587
Multiple mechanisms of meiotic recombination.
Cell Dec, 2006 | Pubmed ID: 17174887
Synthesis-dependent strand annealing in meiosis.
PLoS biology Nov, 2007 | Pubmed ID: 17988174
Brca1 in immunoglobulin gene conversion and somatic hypermutation.
DNA repair Feb, 2008 | Pubmed ID: 18036997
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.
Cancer research Dec, 2007 | Pubmed ID: 18056434
The Yin and Yang of treating BRCA-deficient tumors.
Cell Mar, 2008 | Pubmed ID: 18358803
A comparative analysis of Dmc1 and Rad51 nucleoprotein filaments.
Nucleic acids research Jul, 2008 | Pubmed ID: 18535008
A chemical compound that stimulates the human homologous recombination protein RAD51.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2008 | Pubmed ID: 18840682
The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19270307
Swi2/Snf2-related translocases prevent accumulation of toxic Rad51 complexes during mitotic growth.
Molecular cell Sep, 2010 | Pubmed ID: 20864034
The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.
PLoS genetics Jul, 2011 | Pubmed ID: 21779174
RecA homology search is promoted by mechanical stress along the scanned duplex DNA.
Nucleic acids research Feb, 2012 | Pubmed ID: 22013164
RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.
Nucleic acids research Aug, 2012 | Pubmed ID: 22573178
Rad51 is an accessory factor for Dmc1-mediated joint molecule formation during meiosis.
Science (New York, N.Y.) Sep, 2012 | Pubmed ID: 22955832
Rad51, the lead in mitotic recombinational DNA repair, plays a supporting role in budding yeast meiosis.
Cell cycle (Georgetown, Tex.) Nov, 2012 | Pubmed ID: 23075494
Real-time solution measurement of RAD51- and RecA-mediated strand assimilation without background annealing.
Nucleic acids research Jul, 2013 | Pubmed ID: 23666628
Meiotic crossover control by concerted action of Rad51-Dmc1 in homolog template bias and robust homeostatic regulation.
PLoS genetics , 2013 | Pubmed ID: 24367271
The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors.
Cancer research Jul, 2014 | Pubmed ID: 24753542
The third exon of the budding yeast meiotic recombination gene HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation.
The Journal of biological chemistry Jun, 2014 | Pubmed ID: 24798326
DNA strand exchange and RecA homologs in meiosis.
Cold Spring Harbor perspectives in biology Jan, 2015 | Pubmed ID: 25475089
Gradual implementation of the meiotic recombination program via checkpoint pathways controlled by global DSB levels.
Molecular cell Mar, 2015 | Pubmed ID: 25661491
DNA damage response clamp 9-1-1 promotes assembly of ZMM proteins for formation of crossovers and synaptonemal complex.
Journal of cell science Apr, 2015 | Pubmed ID: 25736290
RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.
Nucleic acids research Mar, 2015 | Pubmed ID: 25765654
Caffeine inhibits gene conversion by displacing Rad51 from ssDNA.
Nucleic acids research May, 2015 | Pubmed ID: 26019181
Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2.
Nucleic acids research May, 2015 | Pubmed ID: 26019182